Apolipoprotein E deletion has no effect on copper-induced oxidative stress in the mice brain.

The current study was designed to investigate effect of copper administration on oxidative damage to the brain in mice and to explore the putative neuroprotective effects rendered by apolipoprotein E (ApoE). Male C57BL/6 and wild-type mice were randomly assigned into four groups, mice wild-type mice treated with either copper or saline. Copper sulphate pentahydrate or saline (200 µl) were administered intragastrically daily for 12 weeks.