Acral persistent papular mucinosis: a rare child case report and literature review.

Background: Acral persistent papular mucinosis (APPM) is a rare idiopathic subtype of localized lichen myxedematosus. To date, there have been less than 41 APPM cases reported worldwide, however, almost all patients were older than 18 years of age. A 7-year-old child was first reported in this paper.

The correlation between rs2501577 gene polymorphism and biliary atresia: a systematic review and meta-analysis.

Importance: Multiple studies indicate a possible correlation between ADD3 rs2501577 and biliary atresia susceptibility; however, a conclusive determination has yet to be made.

Objective: Investigate the role of ADD3 rs2501577 in biliary atresia susceptibility across diverse populations.

Data Sources: The study protocol has been registered on PROSPERO, an international platform for systematic review registration (PROSPERO ID: CRD42023384641).

Expressions of p53 and inducible nitric oxide synthase in congenital choledochal cysts.

Background: Choledochal cyst, an isolated defect unrestricted to the bile duct, is more appropriately regarded as the sentinel feature of a constellation of anomalies affecting the pancreatobiliary system. This study was to assess the relationship between the expression of inducible nitric oxide synthase (iNOS) and the p53 gene as well as the pathogenesis of choledochal cysts.

Methods: iNOS and p53 were detected by immunohistochemistry staining in 26 patients with congenital choledochal cysts.