Publications by authors named "Jiang-Hou Wan"
Article Synopsis
- Multidrug resistance in bladder cancer is linked to mechanisms involving hypoxia, specifically the relationship between the HIF-1 transcription factor and GST-Pi.
- A tissue microarray study with 119 bladder carcinoma cases showed that high expression rates of both HIF-1alpha (57.9%) and GST-Pi (67.2%) were associated with worse clinical outcomes.
- Findings suggest that the co-expression of HIF-1alpha and GST-Pi could serve as a useful indicator for determining the differentiation and chemoresistance in bladder cancer patients.
Article Synopsis
- The study evaluated the effectiveness of combining interferon-alpha (IFN-alpha) and pirarubicin (THP) in preventing the recurrence of superficial transitional cell carcinoma (TCC) after surgery.
- A total of 68 patients were randomly assigned to two groups: one received IFN-alpha with THP, while the other got THP alone, with follow-ups conducted every three months for up to two years.
- Results showed a lower recurrence rate (12.1%) in the IFN-alpha plus THP group compared to the THP group (22.8%), indicating that this combination is more effective in preventing bladder cancer recurrence.
