Ligustrazine induces apoptosis of breast cancer cells in vitro and in vivo.

Introduction: Ligustrazine, the active ingredient present in Umbelliferae plant roots used in Chinese medicine, plays a vital role in reversing multidrug resistance in tumors. This study aims to investigate its anticancer activity and underlying mechanisms in human breast cancer cells in vitro and in vivo.

Materials And Methods: Human breast cancer cell line MDA-MB-231 was incubated with different concentrations of ligustrazine.