Publications by authors named "Jiang-Bo Zou"
Proc Natl Acad Sci U S A
July 2019
Article Synopsis
- BRUCE is a membrane-associated protein that inhibits apoptosis and promotes proteasomal degradation of LC3-I, consequently inhibiting autophagy.
- Under normal conditions, SIP/CacyBP prevents the degradation of BRUCE by inhibiting its ubiquitination, but when DNA damage occurs, Nrdp1 triggers SIP degradation to promote apoptosis.
- During starvation, SIP facilitates the movement of BRUCE for autophagosomal degradation, which suggests a complex relationship between BRUCE, SIP, autophagy, and apoptosis in response to different cellular stressors.
