Effects of Helicobacter pylori and Helicobacter pylori eradication on the microbiota of tongue coating.

Eradicating Helicobacter pylori (H. pylori) can cause an imbalance in the microbiota. Dysbiosis of the gut microbiome may produce multiple diseases and bacterial infections.

National survey questionnaire on the diagnosis and treatment status of in peptic ulcer bleeding disease.

Background And Objective: The Maastricht VI/Florence Consensus and Chinese National Consensus Report provide comprehensive guidelines for treating infection. This study aimed to assess physicians' understanding of and adherence to this consensus in different hospitals.

Methods: Chinese medical staff attending gastrointestinal conferences across various regions were selected for this study.

Esophageal bronchogenic cyst treated with submucosal tunneling endoscopic resection: two case reports.

Introduction: Although esophageal bronchogenic cysts are benign diseases, they may be accompanied by serious complications and have the possibility of recurrence. Therefore, once confirmed, it is necessary to treat the esophagobronchial cyst when the contraindication is excluded. Endoscopic treatment is usually used for lesions with small diameter and shallow origin, and has the advantages of small surgical trauma and risk, which can reduce the psychological burden of patients to a certain extent, help them to recover quickly, and lower hospital costs.

Antibiotic resistance of in Nanjing, China: a cross-section study from 2018 to 2023.

Background: The increasing prevalence of antibiotic resistance in cases of () infection has emerged as a significant global issue. This study offers a comprehensive examination of the alterations in drug resistance exhibited by in the Nanjing region of China during the preceding five years. Another important objective is to investigate the influence of levofloxacin medication history on genotypic and phenotypic resistance.

Phenotype and genotype analysis for antibiotic resistance in outpatients: a retrospective study.

To investigate the antibiotic resistance of () in outpatients and to explore the consistency between genotype and phenotype of antibiotic resistance. A retrospective study on outpatients screened with urea breath test for infection in Nanjing First Hospital from April 2018 to January 2022. Patients who tested positive underwent a consented upper endoscopy, and the infection was confirmed by rapid urease test (RUT) and culture.

Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China.

Our purpose is to investigate the relationship between the microbiota of patients' tongue coating microbiota and the severity of COVID-19, and to identify the severity of COVID-19 patients' condition as early as possible. The participants were categorized into three groups: healthy controls (Con group) consisting of 37 individuals, patients with mild to moderate symptoms (M group) comprising 49 individuals, and patients with severe and critical symptoms (S-C group) consisting of 44 individuals. We collected oral swabs from all participants and performed 16S rRNA gene sequencing to analyze the microbiome.

Oral microbiota may predict the presence of esophageal squamous cell carcinoma.

Purpose: Microbial imbalances have been well elucidated in esophageal adenocarcinoma (EAC), but few studies address the oral microbiota in esophageal squamous cell carcinoma (ESCC). In view of the fact, we aimed to explore the associations of oral microbiota with these patients suffering from ESCC.

Methods: In our study, a total of 109 individuals were enrolled (control = 53, ESCC = 56).

Antibiotic resistance of isolated from patients in Nanjing, China: A cross-section study from 2018 to 2021.

The increasing antibiotic resistance of infection is a globally urging problem. To investigate the resistance situation in Nanjing, China, we enrolled patients in Nanjing First Hospital from January 2018 to May 2021. strains were isolated from patients who had at least one positive 13C-urea breath or rapid urease result.

MiR-877-5p targets PDK-1 to promote aspirin-induced apoptosis in gastric mucosal cells.

This study aimed to investigate the role of miR-877-5p in aspirin-induced gastric mucosal injury. MiRNA microarray analysis was performed using paired gastric mucosal samples to find differentially expressed miRNAs. miR-877-5p was selected for subsequent analyses.

The mechanism of miR-363-3p/DUSP10 signaling pathway involved in the gastric mucosal injury induced by clopidogrel.

Clopidogrel-induced gastric injury is an important clinical problem. However, the exact mechanism is still unclarified. Increasing evidence indicates that miRNAs may be involved in the pathogenesis of gastric mucosal injury.

circRNA RNF111 regulates the growth, migration and invasion of gastric cancer cells by binding to miR‑27b‑3p.

hsa_circ_0001982 [circRNA ring finger protein 111 (RNF111)] has been found to promote cancer growth; however, its role in gastric cancer (GC) remains unclear. The present study examined the effects of circR‑RNF111 on the growth, migration and invasion of GC cells and aimed to elucidate the underlying molecular mechanisms. The expression levels of circR‑RNF111 and miR‑27b‑3p in GC tissues and GC cell lines were detected by reverse transcription‑quantitative PCR (RT‑qPCR).

Analysis of the Primary and Post-Treatment Antibiotic Resistance of Helicobacter pylori in the Nanjing Area.

Background: Resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide. The study was aimed to understand the current situation of antibiotic resistance in Nanjing and to provide a reasonable basis for clinical selection of antibiotics to cure H.

The activation of high mobility group Box1 and toll-like receptor 4 is involved in clopidogrel-induced gastric injury through p38 MAPK.

Clopidogrel-induced gastric injury is an important clinical problem. However, the exact mechanism was still unclarified. This study aimed to investigate the role of high mobility group box protein 1 (HMGB1) and the toll-like receptor 4 (TLR4) pathway in normal human gastric epithelial (GES-1) cells under clopidogrel exposure.

Increased expression of tight junction protein occludin is associated with the protective effect of mosapride against aspirin-induced gastric injury.

Mosapride is known to affect gastric motility, however whether mosapride has anti-ulcergenic effects in gastric mucosal injury is unclear. The aim of the present study was to investigate the effects of mosapride on aspirin-induced gastric injuries. GES-1 cells were cultured and divided into 5 groups: Control group, aspirin injury group (treated with 18.

Increased endoplasmic reticulum stress response is involved in clopidogrel-induced apoptosis of gastric epithelial cells.

Background: The widespread use of clopidogrel alone or in combination with aspirin may result in gastrointestinal mucosal injury, clinically represented as recurrent ulceration and bleeding complications. Our recent work suggested that clopidogrel significantly induced human gastric epithelial cell (GES-1) apoptosis and disrupted gastric mucosal barrier, and that a p38 MAPK inhibitor could attenuate such injury. However, their exact mechanisms are largely unknown.

Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention.

Background: Current medical therapies for patients who have an acute coronary syndrome (ACS) focus on the coagulation cascade and platelet inhibition. These, coupled with early use of cardiac catheterization and revascularization, have decreased morbidity and mortality rates in patients who have acute ischemic heart disease with risk of bleeding.

Objective: The study aimed to determine the incidence of gastrointestinal bleeding after percutaneous coronary intervention (PCI).

Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation.

Bleeding complications and delayed healing of gastric ulcer associated with use of clopidogrel is a common clinical concern; however, the underlying mechanisms remain to be determined. This study aimed to clarify whether clopidogrel could cause the damage of the human gastric epithelial cells and to further elucidate the mechanisms involved. After human gastric epithelial cell line GES-1 had been treated with clopidogrel (0.

Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk.

Background/aims: To explore the association between polymorphism of myeloperoxidase (MPO) gene and the susceptibility to gastric cancer.

Methodology: A case control study of 117 gastric cancer patients and 105 controls was conducted to investigate the polymorphism of MPO gene 463G-A using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The association between polymorphism and the risk of gastric cancer was examined by a multivariate analysis.