Mechanical Interlocking of 144 Symmetrical F and Tetraphenylethylene for Magnetic Resonance-Fluorescence Dual Imaging.

Single-molecule dual F magnetic resonance imaging (F MRI) and fluorescence imaging (FLI) agents are valuable tools in biomedical research. However, integrating millimolar-sensitivity F MRI and micromolar-sensitivity FLI into a single molecule remains challenging. Here, we report the use of mechanically interlocked [5]rotaxanes to efficiently incorporate 144 symmetrical fluorines (F) for sensitive F MRI and to control the motion of tetraphenylethylene (TPE) for responsive FLI at the molecular level, yielding a dual imaging agent with micromolar sensitivity.

Exosomes play a crucial role in remodeling the tumor microenvironment and in the treatment of gastric cancer.

Gastric cancer (GC) is a common and frequent malignant cancer of the digestive system with a poor prognosis. In addition to common therapies such as surgical resection and chemotherapy, novel biological interventions are quite valuable for research. Exosomes are extracellular vesicles (EVs) that originate from various cell types and contain proteins, RNA, DNA, and other components that transmit biological signals and mediate intercellular communication.

The effect-site concentration of remifentanil blunting endotracheal intubation responses in elderly patients during anesthesia induction with etomidate: a dose-exploration study.

Purpose: Laryngoscopy and endotracheal intubation are known to increase activity of the sympathetic nervous system, and are usually associated with perioperative hypertension, cardiac arrhythmia, and tachycardia. The aim of this study was to determine the effect-site concentrations of remifentanil to inhibit the tracheal intubation response during etomidate anesthesia in elderly patients.

Methods: American Society of Anesthesiologists physical status I-III patients aged 65 or older and scheduled for general anesthesia for elective surgery were enrolled in the study.

Large language models for diabetes training: a prospective study.

Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models (LLMs) provide new insights into diabetes training, but their performance in diabetes-related queries remains uncertain, especially outside the English language like Chinese. We first evaluated the performance of ten LLMs: ChatGPT-3.

Full utilization of Flammulina filiformis spent mushroom substrate for sustainable production of oil/water separation bacterial nanocellulose composite with high liquid flux and seperation efficiency.

Bacterial nanocellulose (BNC) is a promising material for oily wastewater separation due to its hydrophilic and nanometer-scale porous structure. However, its application is constrained by high production costs. This study explores the utilization of underutilized Flammulina filiformis spent mushroom substrate (Ff-SMS) to produce BNC cost-effectively.

Association between deep learning radiomics based on placental MRI and preeclampsia with fetal growth restriction: A multicenter study.

Purpose: Preeclampsia (PE) is associated with placental insufficiency and could lead to adverse pregnancy outcomes. The study aimed to develop a placental T2-weighted image-based automatic quantitative model for the identification of PE pregnancies and disease severity.

Methods: Between July 2013 and September 2022, the retrospective multicenter study featured 420 pregnant women, including 140 cases of PE and 280 cases of normotensive pregnancies.

TREM2 protects against LPS-induced murine acute lung injury through suppressing macrophage ferroptosis.

Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor, majorly expressed by granulocytes, monocytes and macrophages. We in this study showed that TREM2 was downregulated in the lipopolysaccharide (LPS)-treated macrophages and murine acute lung injury (ALI) through activation of p38 MAPK and STAT6 signaling. Over-expression of TREM2 reduced the expression of DNAX-activation protein 12 (DAP12), pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), Malondialdehyde (MDA) and hemosiderin accumulation in LPS-treated macrophages.

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model.

Purpose: This study assessed the characteristics of refractive development and choroidal vasculature in the form-deprivation (FD) pigmented rabbit model.

Methods: Monocular FD was performed in three-week-old pigmented rabbits (n = 18 for FD, n = 12 for control). Throughout the eight-week rearing period, refractive errors, corneal curvature radius (CCR), ocular biometric parameters, retinal thickness (RT), and choroidal thickness (ChT) were measured every two weeks using cycloplegic retinoscopy, keratometer, A-scan ultrasonography, and optical coherence tomography (OCT).

Identification and expression pattern analysis of BpGRAS gene family in Bergenia purpurascens and functional characterization of BpGRAS9 in salt tolerance.

Bergenia purpurascens is an important medicinal, edible, and ornamental plant. It generally grows in extreme environments with complex stresses. The GRAS transcription factors play a crucial role in regulating plant stress tolerance and growth-development.

Impressive improvement of zinc-iodine battery performance by doping poly(vinyl alcohol) into the cathode.

Herein, a KB-P60 cathode was synthesized from poly(vinyl alcohol) (PVA) coated Ketjen black (KB). The specific capacity of KB-P60 was increased by 113% from pure KB at 1 A g. In addition, KB-P60 achieved an ultra-long cycle life of 30 000 cycles at 20 A g with minimal degradation, effectively suppressing the shuttle effect.

CDH1-involved Ubiquitination of SIRT5 Promotes the Entry of Colorectal Cancer Cells into Quiescence and Enhances Cell Stemness.

Background: This study explored whether the cell cycle regulator cadherin 1 (CDH1) impacts colorectal cancer cell cycle and stemness via mediating ubiquitination of sirtuin 5 (SIRT5).

Methods: We first constructed CDH1 overexpression plasmid and small interfering RNA against SIRT5 (siSIRT5) and transfected them into HCT116/HT29 cells, followed by transfection efficiency verification. The effect of CDH1 on Cyclin F/SIRT5/CDH1 protein levels in HCT116/HT29 cells was verified by Western blot.

GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model.

Background: Mechanisms driving the development of type A aortic dissection (TAD) are currently poorly understood, and animal models of spontaneous TAD are limited. In the present study, we developed a novel mouse TAD model and evaluated the role of GSDMD (gasdermin D) in TAD development.

Methods: TADs were created by treating the ascending aorta of adult C57BL/6J mice with Act E (active elastase) and β-aminopropionitrile.

Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population.

Background: This study investigates the joint effect of sleep patterns and oxidative balance score (OBS) on all-cause and CVD mortality in the general population.

Methods: We examined 21,427 individuals aged 18-85 from NHANES 2005-2014, connecting them to mortality data until December 31, 2019, using interview and physical examination dates. Surveys collected data on sleep duration, self-reported sleep disturbance, and doctor-told sleep disorders, classified into healthy, intermediate, and unhealthy sleep patterns.

Radiomics prediction of MGMT promoter methylation in adult diffuse gliomas: a combination of structural MRI, DCE, and DTI.

Purpose: To assess the predictive value of radiomics features extracted from structural MRI, dynamic contrast enhanced (DCE), and diffusion tensor imaging (DTI) in detecting O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in patients with diffuse gliomas.

Methods: Retrospective MRI data of 110 patients were enrolled in this study. The training dataset included 88 patients (mean age 52.

Tilting Pad Thrust Bearing Fault Diagnosis Based on Acoustic Emission Signal and Modified Multi-Feature Fusion Convolutional Neural Network.

Tilting pad thrust bearings are widely utilized in large rotating machinery such as steam turbines and hydraulic turbines. Defects in their shaft tiles directly impact lubrication characteristics, thereby influencing the overall safety performance of the entire unit. To address this issue, this paper presents a fault diagnosis method for tilting pad thrust bearings using a modified multi-feature fused convolutional neural network (MMFCNN).

Preliminary Research on Dietary Supplementation of Potassium Magnesium Sulphate on Transport Stress in Finishing Pigs Prior to Slaughter.

Transport stress prior to slaughter frequently induces a stress response, negatively affecting meat quality. This study investigated the impact of dietary potassium magnesium sulphate (PMS) supplementation during the fattening stage on the stress response and meat quality in finishing pigs subjected to transport stress. The experiment involved two phases.

Silicon Nutrition Improves Lodging Resistance of Rice Under Dry Cultivation.

Silicon (Si) has been proven to enhance the stress resistance of rice, but its effect on the lodging resistance of rice under dry cultivation (DCR) is still unclear. The purpose of this experiment is to clarify the appropriate amount of silicon fertilizer for DCR to resist lodging and to elucidate how it coordinates lodging resistance and yield. This experiment used the 'Suigeng 18' cultivar as the material and set six silicon fertilizers (SiO) with dosages of 0, 15, 30, 45, 60, and 75 kg·ha (Si0, Si1, Si2, Si3, Si4, Si5).

The Molecular Mechanism of in Thermal Adaptation of Two Congeneric Oyster Species.

Clock genes regulate physiological and metabolic processes by responding to changes in environmental light and temperature, and genetic variations in these genes may facilitate environmental adaptation, offering opportunities for resilience to climate change. However, the genetic and molecular mechanisms remain unclear in marine organisms. In this study, we investigated the role of a key clock gene, the circadian locomotor output cycles kaput (), in thermal adaptation using DNA affinity purification sequencing (DAP-Seq) and RNA interference (RNAi)-based transcriptome analysis.

A dynamic cobweb resistance network solution based on a structured zeroing neural network and its applications.

Resistor networks are crucial in various fields, and solving problems on these is challenging. Existing numerical methods often suffer from limitations in accuracy and computational efficiency. In this paper, a structured zeroing neural network (SZNNCRN) for solving the mathematical model of time-varying cobweb resistance networks is proposed to address these challenges.

Interaction of zinc oxide nanoparticles and nanorods with immunoglobulin G and underlying effects on MCF-7 breast cancer cells.

Protein corona formation is significantly impacted by the physicochemical characteristics of nanomaterials. The interaction of zinc oxide nanoparticles (ZnO NPs) and nanorods (NRs) with human immunoglobulin G (IgG) was investigated. Additionally, the anticancer effects of ZnO NPs and ZnO NRs in the forms of pristine or combined with protein coronas were evaluated in MCF-7 breast cancer cells.

Dynamic integration of feature- and template-based methods improves the prediction of conformational B cell epitopes.

The accurate prediction of conformational epitopes promotes our understanding of antigen-antibody interactions. All existing algorithms depend on a feature-based strategy, which limits their performance. A template-based strategy can provide complementary information, and the interplay between these two strategies could improve the prediction of epitopes.

The effects of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy.

Background: Stress cardiomyopathy (SCM) currently has a high incidence in older adults, and the theories regarding its causes include "catecholamine myocardial toxicity" and "sympathetic hyperactivation". However, the role of the central nervous system in the pathogenesis of SCM remains unknown. We investigated the role of microglia activation in the paraventricular hypothalamic nucleus (PVN) in the development of SCM.

Associations of waist circumference and BMI with the trajectory of cardiometabolic multimorbidity in hypertensive patients: A multi-state model.

Background And Aims: The burden of cardiometabolic multimorbidity (CMM) in hypertensive patients is substantial, and obesity may play an important role in progression of CMM. We aim to explore associations of obesity with the transition patterns from hypertension to first cardiometabolic disease (FCMD), CMM, and death.

Methods And Results: 21 286 hypertensive patients over 40 were enrolled in Yinzhou Health Information System from 2010 to 2015, followed until June 30, 2022.

Modulating Defect Concentration of Boron Nitride Flowers for CO Photoreduction.

The efficient conversion of carbon dioxide into high-value chemicals presents a promising strategy for achieving carbon neutrality. Defects play a critical role in numerous catalytic reactions. However, an excessive number of defects can lead to electron trapping, deactivating the catalyst surface.

Layout optimization of multi-level cold chain storage facilities in agricultural producing areas considering type and capacity constraints.

The effective circulation of fresh agricultural products is conducive to increasing farmers' income and improving the living standards of urban residents. Cold chain storage facilities in agricultural producing areas play an important role in ensuring the quality of agricultural products, extending the freshness period of goods, and improving logistics efficiency. Different types of fresh produce have different requirements for refrigeration and often require transshipment due to quantity constraints.