Synthesis of Polymers via Cancer Cell Metabolism-Mediated Controlled Radical Polymerization and Application in Engineering of Cell Surface.

In this study, we present a novel chemical biology strategy that leverages the reductive metabolic pathways of cancer cells to develop a new approach for synthesizing polymers in nonstrictly anaerobic conditions. This method utilizes the reductive metabolism of cancer cells to reduce Cu(II) to Cu(I), enabling Cu(I)-catalyzed controlled radical polymerization with poly(ethylene glycol) methyl ether methacrylate (MAPEGOMe) monomer, producing polymers with low dispersity (1.28-1.

Accelerated biological aging increases the risk of short- and long-term stroke prognosis in patients with ischemic stroke or TIA.

Background: Biological age (BA), an integrated measure of physiological aging, has a clear link to stroke. There is a paucity of long-term longitudinal studies about the association between accelerated biological age and stroke prognosis in patients with previous strokes, and the differences in the predictive ability of various BA indicators calculated from clinical biochemistry biomarkers for future stroke outcomes are still unknown. To evaluate the role of three accelerated BA indicators for short- and long-term prognosis of patients with ischemic stroke or transient ischemic attack (TIA), and to identify the most appropriate predictor.

Assessing the Impact of Elevation and Seasonality on the Detection of Medium- to Large-Sized Mammals by Camera Traps.

Factors such as elevation, season, and micro-environment may introduce bias and should be evaluated to minimize potential errors. Our findings revealed the significant impacts of altitude and season on the number of cameras and monitoring duration required in camera trap surveys. The optimal strategy for monitoring mammals is to increase the number of cameras and decrease the sampling period at lower elevations, to add more cameras and extend the sampling time during the dry season due to seasonal differences in capture ratio and species richness.

High selectivity electrocatalytic reductive amination of α-keto acids to alanine over cuprous oxide nanowires.

Herein, cuprous oxide (CuO) nanowires are synthesized by a simple process, realizing the high selectivity electrocatalytic reductive amination of biomass-derived pyruvate to alanine (organic product selectivity: ∼100%). Importantly, a total of 8 different amino acids can be efficiently synthesized using CuO nanowires, confirming the universality of CuO nanowires.

Establishment of an Idiosyncratic Drug-Induced Liver Injury Model on a Stacked Array Chip for Identification of CCL5-Mediated Paracrine Dynamics.

Idiosyncratic drug-induced liver injury (iDILI) poses significant challenges in both drug development and clinical practice due to its unpredictable nature and poorly understood mechanism. The current iDILI models are limited in their ability to replicate dynamic paracrine signaling in the inflammatory microenvironment. Here, we develop an iDILI model on a stacked array chip, allowing ease of assembly and disassembly for precise temporal manipulation of 3D liver microtissue and macrophages.

Disentangling the role of biotic and abiotic factors in shaping microbial biogeographic patterns in the large spatial scale ocean.

Across large oceanic spatial scales, the mechanisms governing microbial community composition remain poorly understood, particularly regarding the influence of biotic factors. In this study, samples were collected over a 3772.55-km transect in the Western Pacific surface waters, with 16S and 18S ribosomal RNA gene sequencing employed to elucidate the assembly processes and drivers of microbial communities.

Beyond low-density lipoprotein cholesterol levels: Impact of prior statin treatment on ischemic stroke outcomes.

Although essential for cardiovascular therapy, the pleiotropic effects of statins on ischemic stroke lack clinical evidence. This study examined the effects of statins beyond low-density lipoprotein cholesterol (LDL-C) levels on mortality and stroke severity. A total of 825,874 patients with ischemic stroke were included in this study, of whom 125,650 statin users were 1:1 matched with non-users based on their LDL-C levels (±0.

Fabrication of functional interface on magnetic beads via various amino acids and their application in chemiluminescent immunoassay as carrier.

Magnetic polymer microspheres with superparamagnetism, high specificity, and monodispersity play a crucial role in the field of in vitro diagnostics. However, the surface modification process of magnetic beads is often complex, and it remains a significant challenge to prepare high-performance magnetic beads easily. To overcome these drawbacks, herein we fabricated functional interface on magnetic bead with the various amino acid via the ring-opening reaction of amino acids with epoxy groups, with attempt to produce carboxylated magnetic beads (MPS-GA) in a convenient way.

Experimental and proteomics evidence revealed the protective mechanisms of Shemazhichuan Liquid in attenuating neutrophilic asthma.

Background: Neutrophilic asthma (NA) is one of the most important phenotypes of non-Th2 asthma and is often insensitive to glucocorticoid therapy, making current treatment difficult. Shemazhichuan Liquid (SMZCL), a Chinese medicine compound preparation, has unique advantages in the treatment of asthma. However, the underlying mechanisms of SMZCL in treating NA are not fully understood.

Integrated untargeted/targeted metabolomics identifies a putative oxylipin signature in patients with atrial fibrillation and coronary heart disease.

Background And Objective: Atrial fibrillation (AF) and coronary heart disease (CHD) are closely related to metabolic dysregulation. However, the metabolic characteristics of AF patients with concomitant CHD remain unclear. The aims of this study were to elucidate the metabolic profiles of patients with AF and CHD to seek new therapeutic targets and related factors of AF combined with CHD.

NO inhibitory constituents from Glycosmis craibii var. glabra.

Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (3-5), along with seven known analogs (6-13), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis.

High-purity Hägg carbide supported by g-CN for CO hydrogenation to liquid fuel.

A unique synthesis strategy that combines grinding and microwave-assisted heating was proposed to expediently fabricate iron nanoparticles supported by g-CN. The resulting catalyst exhibits high-purity FeC with a core-shell structure during the reaction process. Under relevant industrial conditions (320 °C, 2.