miR-138-5p inhibits healing of femoral fracture osteogenesis in rats by modulating osteoblast differentiation via SIRT1/FOXO1 axis.

Background: MicroRNAs have a crucial part to play in maintaining bone formation, signaling, and repair. This research explored the involvement miR-138-5p in modulating osteoblast differentiation in femoral fractures model.

Methods: The role of mir-138-5p in the healing process of femoral fractures in rats was assessed through micro computed tomography (CT) imaging.

Solar-powered light-modulated microwave programmable metasurface for sustainable wireless communications.

Programmable metasurface holds big promise in wireless communications by virtue of its powerful capability in controlling electromagnetic waves. However, challenges exist for the programmable metasurface in achieving self-sufficient renewable energy supply and flexible and reliable multi-domain information transmissions. Here, we report a solar-powered light-modulated microwave programmable metasurface (SLMPM) by integrating a photovoltaic module to acquire information from modulated light and energy from sunlight simultaneously.

Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis.

Introduction: Rheumatoid arthritis (RA) promotes the onset and progression of sarcopenia, yet mechanisms of co-morbidity between RA and sarcopenia are under-explored. Therefore, this study integrated Gene Expression Omnibus (GEO) and Genome-wide association studies (GWAS) data to comprehensively identify shared genes, associated mechanisms, and biological pathways in RA and sarcopenia.

Methods: Utilizing two GEO datasets-GSE226151, which includes 60 RNA-seq samples of skeletal muscle from healthy aged, pre-sarcopenia, and sarcopenia individuals, and GSE55235, with 20 RNA-seq samples of synovial tissue from healthy and RA joints-we performed differentially expressed genes analysis, weighted gene co-expression network analysis to identify crosstalk genes in RA and sarcopenia, and enrichment analysis for these genes.

Rewritable Triple-Mode Light-Emitting Display.

Despite great progress in developing mode-selective light emission technologies based on self-emitting materials, few rewritable displays with mode-selective multiple light emissions have been demonstrated. Herein, we present a rewritable triple-mode light-emitting display enabled by stimuli-interactive fluorescence (FL), room-temperature phosphorescence (RTP), and electroluminescence (EL). The display comprises coplanar electrodes separated by a gap, a polymer composite with FL inorganic phosphors (EL/FL layer), and a polymer composite with solvent-responsive RTP additives (RTP layer).

Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome.

Objective: The body roundness index (BRI) and circadian syndrome (CircS) are considered new risk factors for cardiovascular disease (CVD), yet it remains uncertain whether elevated BRI is associated with CVD incidence in CircS patients. In this study, we investigated the association between BRI and CVD occurrence among CircS participants.

Methods: We conducted a retrospective cohort study involving 8,888 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS 2011-2020 wave).

Applying machine learning to predict bowel preparation adequacy in elderly patients for colonoscopy: development and validation of a web-based prediction tool.

Background: Adequate bowel preparation is crucial for effective colonoscopy, especially in elderly patients who face a high risk of inadequate preparation. This study develops and validates a machine learning model to predict bowel preparation adequacy in elderly patients before colonoscopy.

Methods: The study adhered to the TRIPOD AI guidelines.

Reverse Potts shunt in severe pulmonary hypertension: A 20-year retrospective review.

Pulmonary arterial hypertension (PAH) is a multifactorial heterogeneous condition characterized by elevated pulmonary artery pressure, leading to increased right ventricular afterload and ultimately resulting in right heart failure. Despite major advances in the management of pediatric PAH in recent years with the development of PAH-specific drug therapy and therapeutic strategies, prognosis still remains unsatisfactory for many children. The Potts shunt, as a palliation in patients with cyanotic congenital heart defects first, receives its 'second life' in treating PAH by creating a shunt between the pulmonary artery and the descending aorta to alleviate right heart burden.

Influence of COVID-19 Vaccination on Treatment-Related Adverse Events and Oncologic Outcomes of Nonmetastatic Nasopharyngeal Carcinoma.

Background: The influence of COVID-19 vaccination before chemoradiotherapy on nonmetastatic nasopharyngeal carcinoma (NPC) is not known.

Methods: Propensity score matching was used to minimize potential selection bias between groups. Primary endpoints were treatment-related adverse events (TRAEs).

Anisotropic Resonant Tunneling in Twist-Stacked van der Waals Heterostructure.

Resonant tunneling, with energy and momentum conservation, has been extensively studied in two-dimensional van der Waals heterostructures and has potential applications in band structure probing, multivalued logic, and oscillators. Lattice alignment is crucial in resonant tunneling transistors (RTTs) for achieving negative differential resistance (NDR) with a high peak-to-valley ratio (PVR) because twist-angle-induced momentum mismatch can break the resonant tunneling condition. Here, we report anisotropic resonant tunneling in twist-stacked ReSe/-BN/ReSe RTTs, where the PVR exhibits a strong dependence on the twist angle between the two ReSe layers, reaching a maximum at the twist angle of 102°.

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.

Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline. Cordycepin, the main component of Cordyceps militaris, has anti-inflammatory, antioxidant and neuroprotective effects. In this study, the anti-fatigue effect and potential mechanism of action of cordycepin were investigated using a forced exercise mouse model.

Association of proteomics with lymph node metastasis in early gastric cancer patients.

Surgical decision making for early gastric cancer (EGC) is heavily influenced by its metastasis into the lymph nodes. Currently, the clinicopathological features of EGC cannot be used to accurately distinguish between EGC patients with and without lymph node metastasis. Our retrospective case-matching study included a total of 132 samples from 66 pairs of EGC patients with or without lymph node metastasis and conducted proteomic assays.

Insights into sexual dimorphisms: Analysis of lipid metabolites, biochemical markers, and sex steroid profiling in serum of captive Chinese Sturgeon (Acipenser sinesis) at early stage of gonadal development.

The Chinese sturgeon (Acipenser sinensis) is a critically endangered species, yet there is a limited knowledge regarding the sexual dimorphism in their reproductive biology, hindering long-term conservation efforts through artificial propagation. This study determined and compared the serum steroid hormones, lipid metabolites, biochemical parameters, and fatty acid profiles between male and female Chinese sturgeon (11 years old). Results revealed that male sturgeons exhibited significantly higher levels of serum testosterone, dihydrotestosterone, and 7α, 25-dihydroxycholesterol compared to females (P < 0.

Enhanced piezo-photocatalytic performance of WO/BaTiO heterojunctions under synergistic broad-spectrum light and ultrasound excitation.

Rational regulation of the migration and separation of photogenerated charge carriers is a pivotal strategy for optimizing photocatalytic activity. To maximize the potential of piezoelectric and plasmonic properties, WO/BaTiO heterostructures were fabricated via a straightforward solvothermal process. As anticipated, the WO/BaTiO heterostructures demonstrated a significantly enhanced piezo-photocatalytic degradation of tetracycline under ultraviolet, visible, and near-infrared light irradiation combined with ultrasound stimulation, outperforming both bare BaTiO and WO.

ABVS breast tumour segmentation via integrating CNN with dilated sampling self-attention and feature interaction Transformer.

Given the rapid increase in breast cancer incidence, the Automated Breast Volume Scanner (ABVS) is developed to screen breast tumours efficiently and accurately. However, reviewing ABVS images is a challenging task owing to the significant variations in sizes and shapes of breast tumours. We propose a novel 3D segmentation network (i.

Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds.

Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecular targets and insufficient research on mechanisms of action. In this study, we developed a new RPL19-TRAP-seq method, combining CRISPR/Cas9 and TRAP technologies, to investigate these mechanisms. We identified and validated seven ribosomal large subunit surface proteins suitable for TRAP, selecting RPL19 for its high enrichment.

Impact of pilot public hospital reform on efficiencies: a DEA analysis of county hospitals in East China, 2009-2015.

Background: China started a pilot public hospital reform in 2012 to improve governance and efficiency in healthcare services delivery among county-level hospitals. This study aims to investigate the impact of the pilot reform on hospital efficiency and productivity by using a unique dataset of county hospitals in East China during 2009-2015.

Methods: A three-stage approach is used.

Wearable PPG Based BP Estimation Methods: A Systematic Review and Meta-Analysis.

This meta-analysis and systematic review, conducted in accordance with PRISMA guidelines, explores the efficacy of cuff-less blood pressure (BP) monitoring methods, particularly focusing on photoplethysmogram-based technologies. This comprehensive analysis carefully searched prominent databases such as MEDLINE, PubMed, AMED, Embase, and IEEE-Xplore, encompassing 25 studies with a collective participant pool of 21,142 individuals. The study primarily investigates the accuracy and practicality of continuous BP estimation devices and algorithms, aiming to assess their suitability for daily or long-term, as well as their applicability and usability across a broad population.

Difference Analysis on Virulence Genes, Biofilms and Antimicrobial Susceptibility of from Clinical and Subclinical Bovine Mastitis.

() has the ability to induce clinical and subclinical mastitis in dairy cows, causing a huge loss for the dairy industry. In this study, 51 subclinical mastitis isolates and 36 clinical mastitis isolates from eight provinces of China between 2019 and 2021 were used to investigate the differences in their biological characteristics. The results showed that B1 (52.

Fatal Toxoplasmosis in Red Kangaroos () in East China.

Background: As a ubiquitous apicomplexan parasite, causes huge economic losses and poses a great threat to the health of animals, including humans, worldwide. In some kangaroo species, can be fatal. To date, little information is available on infection in the red kangaroos in east China.

Type I TR and ROP16 Synergistically Downregulate IL-12 to Inhibit Host Reactive Oxygen Species Production.

is an obligate intracellular opportunistic protozoan parasite. invasion disturbs the balance between reactive oxygen species (ROS) production and antioxidant capacity in the host, triggering the oxidative stress response. Thioredoxin reductase (TR) of helps to escape ROS-induced damage in the host, whereas rhoptry protein 16 (ROP16) downregulates host innate immunity to suppress excessive inflammation and inhibit ROS production.

Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players.

Background: This study investigated the effects of combined Rhodiola rosea (RHO) and caffeine (CAF) supplementation on lower limb explosive power and fatigue recovery in volleyball players, aiming to validate their potential synergistic effects.

Methods: A randomized, double-blind, placebo-controlled design was implemented involving 48 male volleyball athletes allocated into four groups: placebo (CTR), Rhodiola rosea (RHO), caffeine (CAF), and combined (RHO + CAF). Over four weeks, participants engaged in twice-weekly high-intensity lower limb resistance training, with performance evaluated through multiple tests, including two-step-approach jump height, countermovement jump (CMJ), five-jump test (5 JT), continuous 20 vertical jumps, and intermittent jump recovery alongside Rate of Perceived Exertion (RPE) assessments.

Muscle Characteristics Comparison Analysis Reveal Differences in the Meat Quality and Nutritional Components of Three Shanghai Local Pig Breeds.

To study the differences in meat quality and nutritional components between the local Shanghai pig breeds Meishan pig (MS), Shawutou pig (SWT), Fengjing pig (FJ), and the commercial Duroc × Landrace × Yorkshire (DLY) crossbred pigs, and to provide data support for the selection and breeding of superior pig breeds, this study selected 30 piglets each of three local pig breeds and DLY with similar birth ages and weights around 25 kg, fed them the same daily ration with uniform nutritional components, and slaughtered ten of them at around 100 kg weight for evaluation of differences in meat quality indicators (primarily intramuscular fat content, tenderness value, texture, etc.) and amino acid content among the varieties. The results indicated significant differences among the four pig breeds in intramuscular fat content, with MS having the highest content and significant differences in tenderness value compared to the other three breeds ( < 0.

Exchange Coupling-Induced Spin Dynamic Damping Modulation at the Py/FeMn Interface.

The spin dynamic damping is crucial for applications in magnetic memory, sensors, and logical systems. Here, focusing on interfacial antiferromagnetic exchange coupling, the magneto-dynamics of NiFe(Py)/FeMn(FeMn) bilayers is systematically investigated. When the FeMn thickness exceeds 5 nm, an interfacial exchange bias field appears, significantly increasing the spin dynamic damping of the Py/FeMn bilayer to around 0.