Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway.

Background: Epigenetic modifications have been proved to play important roles in the spinal degenerative diseases. As a type of noncoding RNA, the microRNA (miRNA) is a vital class of regulatory factor in the epigenetic modifications, while the role of miRNAs in the regulation of epigenetic modifications in ligamentum flavum hypertrophy (LFH) has not been fully investigated.

Methods: The miRNA sequencing analysis was used to explore the change of miRNA expression during the fibrosis of ligamentum flavum (LF) cells caused by the TGF-β1 (10 ng/ml).

ENO1 promotes PDAC progression by inhibiting CD8 T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling.

Metabolic reprogramming is a hallmark of cancer. The"Warburg effect", also known as aerobic glycolysis, is an essential part of metabolic reprogramming and a central contributor to cancer progression. Moreover, hypoxia is one of the significant features of pancreatic ductal adenocarcinoma (PDAC).

Coastal redox shifts over the past 167 years and preservation of total organic carbon and total nitrogen.

This study reconstructs the environmental history of Xincun Lagoon over the past 167 years using sediment core XCW, employing Cu/Zn as a proxy for redox changes. Time-series analysis of Cu/Zn ratios reveals a significant decline (linear regression slope = -0.00082, p < 0.

IR-Driven Multisignal Conditioning for Multiplex Detection: Thermal-Responsive Triple DNA-Mediated Reconfigurable Photoelectrochemical/Photothermal Dual-Mode Strategy.

Superior to traditional multiplex photoelectrochemical (PEC) sensors, integrated multitarget assay on a single reconstructive electrode interface is promising in real-time detection through eliminating the need of specialized instrumentation and cumbersome interfacial modifications. Current interface reconstruction approaches including pH modulation and bioenzyme cleavage involve biohazardous and time-consuming operations, which cannot meet the demand for rapid, eco-friendly, and portable detection, which are detrimental to the development of multiplex PEC sensors toward portability. Herein, we report a pioneer work on IR-driven "four-to-one" multisignal conditioning to facile reconfigure electrode interface for multitarget detection via photoelectrochemical/photothermal dual mode.

Thiol-Ene Click Chemistry: A General Strategy for Tuning the Properties of Vinylene-Linked Covalent Organic Frameworks.

Vinylene-linked Covalent Organic Frameworks (V-2D-COFs) are a class of promising porous organic materials that feature fully π-conjugated structures, high crystallinity, ultrahigh chemical stability, and extraordinary optoelectronic properties. However, the types of reactions and the availability of monomers for synthesizing linked COFs are considerably limited by the irreversibility of the C═C bond, and the complete π-conjugated structure restricts their in-depth research in hydrophilicity, membrane materials, and proton conductivity. Postsynthetic modification (PSM), which can avoid these problems by incorporating functional moieties into the predetermined framework, provides an alternative way to construct diverse V-2D-COFs.

Basic Science and Pathogenesis.

Background: The immunoproteasome (IP) is the inducible form of the constitutive 20S proteasome upregulated in immune cells. The IP consists of 3 inducible β subunits (β1i - LMP2, β2i - MECL1, and β5i - LMP7), which generate MHC-I compatible peptides. IPs are induced by pro-inflammatory cytokine signaling, as well as oxidative stress signaling.

Basic Science and Pathogenesis.

Background: The ubiquitin-proteasome system (UPS) is the primary protein degrading mechanism in eukaryotes, and is essential for cellular homeostasis. Dysregulation of the UPS has been linked to neurodegeneration through two hallmarks, pathogenic protein aggregation and aberrant proteostasis. However, the molecular changes that alter proteasome functioning in AD are poorly understood.

Clinical Manifestations.

Background: The intricate and heterogeneous phenotypes associated with neuropsychiatric symptoms (NPSs) encumber exploration of their role in the neuropathology and underlying biological mechanisms of Alzheimer's disease (AD) continuum.

Method: An individual-level Regional Radiomics Similarity Network (R2SN) for 487 patients with AD continuum (376 with NPSs vs. 111 without NPSs) were developed to find the R2SN connections associated with NPSs and refine the subtypes of NPS in the AD continuum.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Fiber Vector Light-Field-Based Tip-Enhanced Raman Spectroscopy.

Tip-enhanced Raman spectroscopy (TERS) has been extensively employed to investigate the light-matter interaction at the nanoscale. However, the current TERS strategies lack the ability to excite the low-background inhomogeneous electromagnetic field with significant enhancement of electric field, electric field gradient, and optomagnetic field, simultaneously. To overcome this, we developed a fiber vector light-field-based TERS strategy aimed at exploring the multipole Raman scattering processes of molecules.

A novel liquid-liquid phase separation-related gene signature for predicting prognosis in colon cancer.

Background: An increasing body of evidence indicates that dysregulation of liquid-liquid phase separation (LLPS) in cellular processes is implicated in the development of diverse tumors. Nevertheless, the association between LLPS and the prognosis, as well as the tumor immune microenvironment, in individuals with colon cancer remains poorly understood.

Methods: We conducted a comprehensive evaluation of the LLPS cluster in 1010 colon cancer samples from the TCGA and GEO databases, utilizing the expression profiles of LLPS-related prognostic differentially expressed genes (DEGs).

LiZrF protective layer enabled high-voltage LiCoO positive electrode in sulfide all-solid-state batteries.

The application of high-voltage positive electrode materials in sulfide all-solid-state lithium batteries is hindered by the limited oxidation potential of sulfide-based solid-state electrolytes (SSEs). Consequently, surface coating on positive electrode materials is widely applied to alleviate detrimental interfacial reactions. However, most coating layers also react with sulfide-based SSEs, generating electronic conductors and causing gradual interface degradation and capacity fading.

Conditions for shale gas accumulation and the gas-bearing factors of the Wufeng-Longmaxi formation in the Laifeng-Xianfeng area.

In this work, taking wells LD1, LD2, and LY2 in the Laifeng-Xianfeng area as the research target, through core description, intensive core sampling, experimental analysis, imaging logging and other methods, the characteristics of graptolite zone development, organic carbon content, mineral composition, shale reservoir properties and the gas-bearing properties of the Wufeng-Longmaxi Formation shale are systematically analyzed. The main factors affecting the gas-bearing capacity of the Wufeng-Longmaxi Formation shale are extensively evaluated. The results reveal the following: ① The Wufeng-Longmaxi Formation shale, which was deposited in a deep-water shelf environment, has a large thickness (50-60 m) and a stable distribution.

Trace Cu Doping Enabled High Rate and Long Cycle Life Sodium Iron Phosphate Cathode for Sodium-Ion Batteries.

NaFe(PO)(PO) (NFPP) is currently receiving a lot of attention, as it combines the advantages of NaFePO and NaFePO in terms of cost, energy density, and cycle stability. However, the issues of intrinsic poor electronic conductivity and difficult high-purity preparation may impede its practical application. Herein, the pivotal role of Cu doping in strengthening the polyanion structure and improving its electrochemical properties is comprehensively investigated.

Ultrasound-assisted ionic liquid extraction of polysaccharides from Crataegus songarica K. Koch fruits: Structural characterization and Antioxidant Activity.

In this study, we optimal the ultrasound-assisted ionic liquid extraction (UAILE) process of polysaccharides from Crataegus songarica K. Koch fruits. The optimal conditions determined were: ultrasonic power of 400 W, temperature of 79 ℃, extraction time of 78 min, Ethylammonium dodecyl sulfate (EADS) concentration of 1.

Oncogenic RARγ isoforms promote head and neck cancer proliferation through vinexin-β-mediated cell cycle acceleration and autocrine activation of EGFR signal.

Results of retinoid-based therapies in head and neck cancer (HNC) are generally disappointing, indicating a lack of understanding of retinoic acid signaling. The role of retinoic acid receptor gamma (RARγ) and its isoforms in HNC is yet to be established. In this study, we found that RARγ1, 2, 4 are the predominant RARγ isoforms expressed in various types of human cancers, including HNC.

Liver B Cells Promotes MASLD Progression via the Apelin/APLNR System.

Investigate the role of the apelin/APLNR axis in metabolic dysfunction-associated steatotic liver disease (MASLD), focusing on the progression from metabolic dysfunction-associated simple steatotic liver (MASS) to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis, with emphasis on liver B cells. Serum samples from MASLD patients and liver tissues from hepatocellular carcinoma patients were collected to measure apelin and APLNR protein expression. C57BL/6J mouse models of varying MASLD stages were developed using a high-fat diet and CCl.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Adaptive evaluation of gross total resection rates for endoscopic endonasal approach based on preoperative MRI morphological features of pituitary adenomas.

Objective: This study aims to define a set of related anatomical landmarks based on preoperative Magnetic Resonance Imaging (MRI) of patients with pituitary adenomas (PAs). It explores the impact of the dynamic relationships between different anatomical landmarks and the tumor on the resection rate and tumor progression/recurrence during the endoscopic endonasal approach (EEA).

Methods: A single-center institutional database review was conducted, identifying patients with PAs treated with EEA from December 2018 to January 2023.

Impaired Megakaryopoiesis due to Aberrant Macrophage Polarization via BTK/Rap1/NF-κB Pathway in Sepsis-induced Thrombocytopenia.

Sepsis-induced thrombocytopenia (SIT) is a widely accepted predictor of poor prognosis during sepsis, while the mechanism of SIT remains elusive. In this study, we revealed that SIT patients and septic mice exhibited higher levels of pro-inflammatory macrophages and phosphorylated BTK (p-BTK) expression in macrophages, which were closely correlated with platelet counts. Treatment with the BTK inhibitor, BGB-3111 in SIT mice resulted in enhanced production of megakaryocytes and platelets.

High altitudes, deeper insights: multicenter cardiovascular magnetic resonance study on hypertrophic cardiomyopathy.

Objectives: Altitude is a known factor in cardiovascular disease, but its impact on hypertrophic cardiomyopathy (HCM) patients remains unclear. This study aimed to determine whether living at high altitudes affects the extent of late gadolinium enhancement (LGE) and left ventricular (LV) strain in HCM patients.

Methods: This retrospective cross-sectional study was conducted across four hospitals located at different altitudes in China.

Bionic Hollow Porous Carbon Nanofibers for Energy-Dense and Rapid Zinc Ion Storage.

Suboptimal spatial utilization and inefficient access to internal porosity preclude porous carbon cathodes from delivering high energy density in zinc-ion hybrid capacitors (ZIHCs). Inspired by the function of capillaries in biological systems, this study proposes a facile coordination-pyrolysis method to fabricate thin-walled hollow carbon nanofibers (CNFs) with optimized pore structure and surface functional groups for ZHICs. The capillary-like CNFs maximize the electrode/electrolyte interface area, facilitating the optimal utilization of energy storage sites.

Effect of cold plasma and ultrasonic pretreatment on drying characteristics and nutritional quality of vacuum freeze-dried kiwifruit crisps.

The effect of ultrasound and plasma pretreatment on freeze-dried kiwifruit crisps was investigated in this study. Using unpretreated kiwifruit as a control group (CG), the effects of ultrasound (US), plasma-activated water (PAW), ultrasound combined with plasma-activated water (UPAW), plasma-jet (PJ), and ultrasound combined with plasma-jet (UPJ) on the quality of vacuum freeze-dried kiwifruit were investigated. The results showed that all the pretreatments could change the microstructure of the crisps.

Secondary Prophylaxis of Cirrhotic Gastric Variceal Bleeding: Addition of Non-Selective Beta-Blockers to Endoscopic Combined Treatment.

Background: It remains unclear whether the addition of non-selective beta-blockers (NSBB) provides further benefit after combined use of tissue adhesive and endoscopic variceal ligation for bleeding gastroesophageal varices.

Objective: This is the first cohort study comparing the secondary prophylactic efficacy of adding NSBB to combined endoscopic treatment in cirrhotic patients with gastric varices (without inclusion of isolated gastric varices [IGVs], which are rare in patients with cirrhosis without splanchnic thrombosis).

Methods: We retrospectively analyzed two matched large cohorts of cirrhotic patients with gastric varices who received combined endoscopic treatment and were assigned to receive NSBB treatment or not as secondary prophylaxis.

Tertiary Lymphoid Structures are Linked to Enhanced Antitumor Immunity and Better Prognosis in Muscle-Invasive Bladder Cancer.

The prognosis for muscle-invasive bladder cancer (MIBC) remains poor, and reliable prognostic markers have yet to be identified. Tertiary lymphoid structures (TLS) have been associated with favorable outcomes in certain cancers. However, the relationship between TLS and MIBC remains unclear.