Holey etching strategy of siloxene nanosheets to improve the rate performance of photo-assisted Li-O batteries.

Improving the rate performance is of great significance to achieve high-performance photo-assisted Li-O batteries for developing new optimized bifunctional photocatalysts. Herein, a holey etching strategy is developed to prepare porous siloxene nanosheets with a size of 10 nm and few layers (P-siloxene NSs) by a modified Ag-assisted chemical etching method, and the optimized pore-forming conditions are: Ag ion concentration 0.01 mol dm, HF concentration 0.

SLC7A5 regulates tryptophan uptake and PD‑L1 expression levels via the kynurenine pathway in ovarian cancer.

Ovarian cancer is the third most common gynecological malignancy worldwide and the fifth leading cause of cancer-related death among women. This may be attributed to difficulties in diagnosing early-stage ovarian cancer, as it is typically asymptomatic until metastases, and due to the ineffective management of patients with late-stage ovarian cancer. The aim of the present study was to investigate potential therapeutic targets for the treatment of ovarian cancer.

Fragmented Polymetric Carbon Nitride with Rich Defects for Boosting Electrochemical Synthesis of Hydrogen Peroxide in Alkaline and Neutral Media.

Electrocatalytic oxygen reduction reaction via 2e pathway is a safe and friendly route for hydrogen peroxide (HO) synthesis. In order to achieve efficient synthesis of HO, it is essential to accurately control the active sites. Here, fragmented polymetric carbon nitride with rich defects (DCN) is designed for HO electrosynthesis.

Promoting Proton Donation through Hydrogen Bond Breaking on Carbon Nitride for Enhanced HO Photosynthesis.

Photocatalytic HO production has attracted much attention as an alternative way to the industrial anthraquinone oxidation process but is limited by the weak interaction between the catalysts and reactants as well as inefficient proton transfer. Herein, we report on a hydrogen-bond-broken strategy in carbon nitride for the enhancement of HO photosynthesis without any sacrificial agent. The HO photosynthesis is promoted by the hydrogen bond formation between the exposed N atoms on hydrogen-bond-broken carbon nitride and HO molecules, which enhances proton-coupled electron transfer and therefore the photocatalytic activity.

Pre-Intercalation of TMA Cations in MoS Interlayers for Fast and Stable Zinc Ion Storage.

Applications of aqueous zinc ion batteries (ZIBs) for grid-scale energy storage are hindered by the lacking of stable cathodes with large capacity and fast redox kinetics. Herein, the intercalation of tetramethylammonium (TMA) cations is reported into MoS interlayers to expand its spacing from 0.63 to 1.

Strong Electronic Interaction in High-Entropy Oxide Enhances Oxygen Evolution Reaction.

High-entropy oxides are a new type of material with significant application potential. However, the lack of a universal HEO preparation method severely limits the property study and application of HEOs. Herein, we report a universal approach of spray pyrolysis for the preparation of various HEOs and study the electrocatalytic performance of HEOs toward the oxygen evolution reaction.

Hyperbranched Polymer Dots with Strong Absorption and High Fluorescence Quantum Yield for In Vivo NIR-II Imaging.

In order to improve the fluorescence quantum yield (QY) of NIR-II-emitting nanoparticles, D-A-D fluorophores are typically linked to intramolecular rotatable units to reduce aggregation-induced quenching. However, incorporating such units often leads to a twisted molecular backbone, which affects the coupling within the D-A-D unit and, as a result, lowers the absorption. Here, we overcome this limitation by cross-linking the NIR-II fluorophores to form a 2D polymer network, which simultaneously achieves a high QY by well-controlled fluorophore separation and strong absorption by restricting intramolecular distortion.

A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC-OXPHOS axis.

Background: Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative phosphorylation (OXPHOS), which enables cell growth, migration, and cancer stem cell maintenance, is a critical driver of disease progression and a potential intervention target of OC. However, the current OXPHOS intervention strategy mainly suppresses the activity of the electron transport chain directly and cannot effectively distinguish normal tissues from cancer tissues, resulting in serious side effects and limited efficacy.

The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer.

Kinase inhibitors against Cyclin Dependent Kinase 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects are limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response in lung cancer by forming a feedback loop with CDK6.

Unveiling the Effect of Organic Sulfur Sources on Synthesized MoS Phases and Electrocatalytic Hydrogen Evolution Performances.

Metallic-phase MoS exhibits Pt-comparable electrocatalytic hydrogen evolution reaction (HER) performance in acidic conditions. However, the controllable synthesis of metallic-phase MoS is quite challenging because the key factor determining the phase types of MoS during synthesis is still unclear. Herein, the effect of organic sulfur sources on the formed MoS phase is studied by use of thioacetamide (TAA), l-cysteine, and thiourea as sulfur sources.

Mitochondrial Protease Targeting Chimeras for Mitochondrial Matrix Protein Degradation.

Targeted protein degradation (TPD) is an emerging technique for protein regulation. Currently, all TPD developed in eukaryotic cells relies on either ubiquitin-proteasome or lysosomal systems, thus are powerless against target proteins in membrane organelles lacking proteasomes and lysosomes, such as mitochondria. Here, we developed a mitochondrial protease targeting chimera (MtPTAC) to address this issue.

Size-Controlled Boron-Based Bifunctional Photocathodes for High-Efficiency Photo-Assisted Li-O Batteries.

Photo-assisted Li-O batteries are introduced as a promising strategy for reducing severe overpotential by directly employing photocathodes. Herein, a series of size-controlled single-element boron photocatalysts are prepared by the meticulous liquid phase thinning methods by combining probe and water bath sonication, and their bifunctional photocathodes in the photo-assisted Li-O batteries are systematically investigated. The boron-based Li-O batteries have shown incremental round-trip efficiencies as the sized reduction of boron under illumination.

All-solid-state TiCT neutral symmetric fiber supercapacitors with high energy density and wide temperature range.

All-solid-state TiCT neutral symmetric fiber supercapacitors (PVA EGHG TiCT FSCs) with high energy density and wide temperature range are constructed by using polyvinyl alcohol (PVA)-ethylene glycol hydrogel (EGHG)-sodium perchlorate (NaClO) as electrolyte and separator, and TiCT fiber as electrodes. TiCT fiber is prepared using 130 mg mL TiCT nanosheet ink as an assembly unit in a coagulation bath of isopropyl alcohol (IPA) and distilled water with 5 wt% CaCl by a wet spinning method. The prepared TiCT fiber exhibits a specific capacity of 385 F cm and a capacitance retention of 94 % after 10,000 cycles in 1 M NaClO electrolyte.

Atomically Dispersed Fe-N Sites and NiFe-LDH Sub-Nanoclusters as an Excellent Air Cathode for Rechargeable Zinc-Air Batteries.

The sluggish four-electron processes of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) limit the development of rechargeable Zn-air batteries (RZABs). Highly efficient ORR/OER bifunctional electrocatalysts are therefore highly desired for the commercialization of RZABs in large scale. Herein, the Fe-N-C (ORR active sites) and NiFe-LDH clusters (OER active sites) are successfully integrated within a NiFe-LDH/Fe,N-CB electrocatalyst.

PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.

The therapeutic effects of existing drug regimens against pancreatic neuroendocrine neoplasms (pNENs) remain limited, and identifying ideal therapeutic targets is warranted. PDZ binding kinase (PBK) may play an oncogenic role in most solid tumors. However, its function in pNEN remains unclear.

Single-crystalline Mg-substituted NaMn(PO)PO nanoparticles as a high capacity and superior cycling cathode for sodium-ion batteries.

Mn-based mixed phosphate NaMn(PO)(PO) (NMPP) is a promising cathode for high-potential, low-cost and eco-friendly sodium-ion batteries. However, this material still faces some bottleneck issues in terms of low conductivity, disturbance of impure crystalline phase, micron-sized agglomerated particles and the Mn Jahn-Teller effect. Herein, a Mg-substituted NMPP (NMMgPP)@C composite was constructed modified solution combustion and subsequent calcination treatment.

Integrative proteomic characterization of adenocarcinoma of esophagogastric junction.

The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and subtypes are still obscure. Here, we conduct proteomics and phosphoproteomics profiling of 103 AEG tumors with paired normal adjacent tissues (NATs), whole exome sequencing of 94 tumor-NAT pairs, and RNA sequencing in 83 tumor-NAT pairs. Our analysis reveals an extensively altered proteome and 252 potential druggable proteins in AEG tumors.

Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells.

5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy. However, the development of 5-Fu resistance limits its chemotherapeutic effectiveness and often leads to poor prognoses of CRC. Transglutaminase 2 (TGM2), a member of the transglutaminase family, is considered to be associated with chemoresistance through apoptotic prevention in various cancers including CRC.

Chemo-Phototherapy with Carfilzomib-Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis.

The design of nanomedicine for cancer therapy, especially the treatment of tumor metastasis has received great attention. Proteasome inhibition is accepted as a new strategy for cancer therapy. Despite being a big breakthrough in multiple myeloma therapy, carfilzomib (CFZ), a second-in-class proteasome inhibitor is still unsatisfactory for solid tumor and metastasis therapy.

Few-layer Mg-deficient borophene nanosheets: I oxidation and ultrasonic delamination from MgB.

By using I as an oxidant and CHCN as a reaction medium, few-layer Mg-deficient borophene nanosheets (FBN) with a stoichiometric ratio of MgB are prepared by oxidizing MgB in a mixture of CHCN and HCl for 14 days under nitrogen protection and followed by ultrasonic delaminating in CHCN for 2 h. The prepared FBN possess a two-dimensional flake morphology, and they show a clear interference fringe with a -spacing of 0.251 nm corresponding to the (208) plane of rhombohedral boron.

Interfacial Engineering of Metal/Metal Oxide Heterojunctions toward Oxygen Reduction and Evolution Reactions.

Oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) are two very important electrochemical processes for renewable energy conversion and storage devices. Electrocatalysts are needed to accelerate their sluggish kinetics to improve energy conversion efficiencies. Hence, extensive efforts have been devoted to the development of OER and ORR electrocatalysts with high activity and stability as well as low cost.