MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy.

Radiotherapy (RT) effectiveness is limited by low DNA damage in tumor cells, surrounding tissue harm, and tumor radioresistance with active DNA repair. Herein, we have engineered a two-dimensional nanomaterial consisting of MXene nanosheets at its core, coated with gold nanorods and a cisplatin shell, and further modified with polyvinyl alcohol, referred to as APMP. The APMP exploits its distinctive electronic properties and photothermal effects to augment radiosensitivity and impede DNA damage repair mechanisms.

Genetic and Molecular Differences in Head and Neck Cancer Based on Smoking History.

Importance: Up to 80% of survivors of head and neck squamous cell carcinoma (HNSCC) currently or previously smoked. Thus, tobacco use is a major modifiable risk factor for HNSCC, even in the era of human papillomavirus (HPV)-associated disease. However, how smoking underlies chromosomal and epigenetic changes that are associated with HNSCC outcomes remains unclear.

Contextual Binocular Imbalance Impairs Local Stereopsis.

Purpose: Binocular imbalance is known to inhibit stereopsis. This study investigates whether an imbalanced context around stereo stimuli also affects local stereopsis and explores the underlying mechanisms.

Methods: Three experiments were conducted with normally sighted participants.

Inferring Staphylococcus aureus host species and cross-species transmission from a genome-based model.

Background: Staphylococcus aureus is an important pathogen that can colonize humans and various animals. However, the host-associated determinants of S. aureus remain uncertain, which leads to difficulties in inferring its host species and cross-species transmission.

Electrochemical sensing system based on coordination bond connected porphyrin-MOFs@MXenes hybrids for in situ and real-time monitoring of HO released from cells.

Herein, the coordination bond connected porphyrin-MOFs/MXenes composites has been prepared to construct an electrochemical sensing system for in situ and real-time monitoring of HO released by cells. The composites were synthesized by introducing 4-mercaptopyridine and utilizing its binding interaction with titanium in Mxenes and iron in MOFs. This composite was then transferred to the surface of ITO to construct an electrochemical sensing system.

Embedding Antimony Nanoparticles into a Nitrogen-Doped Porous Carbon Matrix for High-Performance Potassium-Ion Battery Anode.

Antimony (Sb) has the advantages of high theoretical K storage capacity, low alloying potential, and excellent electrical conductivity, and it is a promising active anode material for potassium-ion batteries (PIBs). In this work, a series of Sb/NC nanocomposites were prepared by the sol-gel method and carbothermic reduction technique, encapsulating Sb particles in a nitrogen (N)-doped three-dimensional porous carbon matrix. The results show that Sb/NC nanocomposites with a unique porous structure and optimal Sb content can be obtained by simply adjusting the amount of organic carbon source during the synthesis process.

Preparation and structural optimization of vanadium oxide nanotubes as cathode materials for PIBs with improved performance.

In this work, we synthesized hollow multi-walled vanadium oxide nanotubes (VO -NT) using a soft template technique under hydrothermal reaction conditions. By replacing organic templates, which do not contribute to electrochemical potassium storage, with K in a solution environment, we effectively retained the original hollow multi-walled structure of VO -NT while obtaining the K-VO -NT material. We conducted systematic characterizations of the microstructure, morphology, and composition of these materials and evaluated their potassium storage performance.

Parents' Experiences of Palliative Care Decision Making for Children With Terminal Cancer: A Qualitative Study.

The objective of this study was to describe the experiences and perceptions of parents making palliative care decisions for children with end-stage malignancies. This qualitative study was conducted with 13 parents from 9 families of children with end-stage malignant tumors. Data were analyzed using thematic content analysis.

Concurrent Nasal Symptoms in Non-Rhinogenic Headache.

Objective: This study aims to characterize concurrent nasal symptoms in a cohort of patients with non-rhinogenic headache (NRH) presenting to an otolaryngology clinic.

Study Design: A prospective cohort.

Setting: Single tertiary care institution.

Association between serum vitamin D and depression among non-alcoholic fatty liver disease.

Background And Objectives: While previous population-based studies have suggested a link between serum vitamin D levels and depression in individuals with non-alcoholic fatty liver disease (NAFLD), the exact correlation between serum vitamin D and depression among NAFLD patients remains controversial and disputed. Thus, we conducted this study to evaluate the relationship between serum vitamin D and depression in NAFLD participants diagnosed via transient elastography.

Methods And Study Design: This cross-sectional study was extracted from the latest NHANES 2017-2018 dataset.

Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. Recently, the structural and functional defects of small airways have received attention in the early pathogenesis of IPF. This study aimed to elucidate the characteristics of small airway epithelial dysfunction in patients with IPF and explore novel therapeutic interventions to impede IPF progression by targeting the dysfunctional small airways.

Conjugated Phthalocyanine-Based Mesoporous Covalent Organic Frameworks for Efficient Anodic Lithium Storage.

Organic anode materials have been recognized as promising candidates for low-cost and sustainable lithium-ion batteries (LIBs), which however suffer from the inferior cycling stability and low conductivity with unsatisfactory LIBs performance. Herein, two conjugated phthalocyanine-based covalent organic frameworks (COFs), namely CoPc-Ph-COF and CoPc-3Ph-COF, are synthesized by the nucleophilic substitution reaction of hexafluorophthalocyanine cobalt (II) (CoPcF) with 1,2,4,5-tetrahydroxybenzene and 9,10-dimethyl-2,3,6,7-tetrahydroxyanthracene, respectively. Powder X-ray diffraction and electron microscopy analysis reveal the crystalline porous structure of both COFs with a pore size of 1.

Patient-Reported Distress in Individuals With Head and Neck Cancer.

Importance: Distress is common among patients with cancer, and evidence of disparities associated with distress has been mixed. Head and neck cancer (HNC) is one of the most emotionally distressing cancers and is also a highly disparate disease. However, it is unknown whether there are disparities associated with patient-reported distress in HNC.

Stress-Easing Effect of Diacyl Glyceryl Ethers on Anxiety-Related Behavior in Mice.

Stress and anxiety are significant psychological challenges in modern society, which have led to a rapidly growing market for functional foods, including those reported to relieve stress, as alternatives to psychoactive drugs. Among these, diacyl glyceryl ethers (DAGE) derived from deep-sea shark liver oil have gained attention for their strong antioxidant properties and potential mental health benefits. Building on preliminary evidence suggesting DAGE's efficacy in enhancing stress resilience and modulating biochemical pathways associated with reduced oxidative stress, the present study aimed to examine their effects on stress responses in two specific mouse strains.

Medicine Usage for Hypertension Management in Type 2 Diabetes Patients in the Rural-Urban Fringe Zone, Suzhou City, Jiangsu Province, China.

Objective: Medicine is critical for blood-pressure control in patients with type 2 diabetes mellitus (T2DM), for evaluation of treatment patterns and effects would offer baselines for future health services.

Methods: A cross-sectional study was conducted from August 2018 to January 2021 in the urban-rural fringe zone of Suzhou City, Jiangsu Province, China. Blood pressure and antihypertensive medication use were collected from T2DM patients combined with hypertension (HTN).

Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.

Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile.

Role of diaphragmatic dysfunction in extubation failure among patients at high risk of reintubation: A prospective cohort study.

Purpose: This study aims to evaluate the role of diaphragmatic dysfunction in extubation failure among patients at high risk of reintubation.

Material And Methods: This prospective cohort study was carried out at a intensive care unit in China. Adult patients who had been intubated for more than 24 h and ready for extubation were included in the study if they exhibited a high risk of extubation failure.

Assessment of cloud service trusted state based on fuzzy entropy and Markov chain.

In the era of cloud service popularization, the trustworthiness of service is particularly important. If users cannot prevent the potential trustworthiness problem of the service during long-term use, once the trustworthiness problem occurs, it will cause significant losses. In order to objectively assess the cloud service trustworthiness, and predict its change, this paper establishes a special hierarchical model of cloud service trustworthiness attributes.

Dynamic estimation of the soil environmental carrying capacity for Benzo(a)pyrene in an industrial city, China: Insight from both duration and rate of regional emission.

An in-depth investigation of the maximum environmental load is crucial for soil security and pollution prevention. This research focused on soil environmental carrying capacity (SECC) for different risk receptors in a Chinese industrial city. By determining risk threshold for various land use types, we integrated mass balance and iterative models to capture dynamic net input fluxes with spatial heterogeneity.

Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization.

Given the high recurrence rate of kidney stones, surgical lithotripsy and stone removal are not the ultimate treatments for kidney stones. There's an urgent need to explore the genetic mechanisms behind the susceptibility to kidney stones and to identify potential targets for prevention, to reduce the renal damage caused by recurrent stone formation. In this study, we screened 4548 circulating proteins using proteome-wide Mendelian Randomization (MR) to find proteins with a causal relationship to kidney stone risk.

Dominant drivers of vegetation changes in key ecological barrier of northeastern Tibetan Plateau since 2000: Human impacts or natural forces?

Human activities and natural forces have profoundly influenced vegetation ecosystems in the Tibetan Plateau over the recent decades. However, contributions of these two driving forces to vegetation changes remain controversial, especially in the ecological barriers like the Qilian Mountains (QM) in the northeast where many protecting measures and strategies were applied to enhance ecosystem stability and services. Our study employed a process-based model and a multi-perspective assessment method to determine dominant drivers of vegetation changes in the QM since 2000.

Factors affecting community pharmacists' capacity to deliver pharmacy services in Zhengzhou, China: a cross-sectional study.

Objective: To assess the factors that affect the capacity of community pharmacists to deliver pharmacy services (PSs) in Zhengzhou, China.

Design: An online, cross-sectional survey was conducted.

Setting And Participants: A stratified sampling method was used to select community pharmacists for questionnaires.

Targeting Lactate: An Emerging Strategy for Macrophage Regulation in Chronic Inflammation and Cancer.

Lactate accumulation and macrophage infiltration are pivotal features of both chronic inflammation and cancer. Lactate, once regarded merely as an aftereffect of glucose metabolism, is now gaining recognition for its burgeoning spectrum of biological roles and immunomodulatory significance. Recent studies have evidenced that macrophages display divergent immunophenotypes in different diseases, which play a pivotal role in disease management by modulating macrophage polarization within the disease microenvironment.

Activity of polymyxin B combined with cefepime-avibactam against the biofilms of polymyxin B-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae in in vitro and in vivo models.

Bacterial biofilms, often forming on medical devices, can lead to treatment failure due to their increased antimicrobial resistance. Cefepime-avibactam (CFP-AVI) exhibits potent activities against Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K.