Analysis of risk factors for radiation-induced oral mucositis for nasopharyngeal carcinoma and prognostic value of EGF and STREM-1.

Background: This study analyzed the risk factors of radiation-induced oral mucositis (RIOM) for nasopharyngeal carcinoma (NPC) and the correlation between epidermal growth factor (EGF), soluble myeloid cell expression trigger receptor-1 (sTREM-1), and disease severity.

Methods: A total of 124 patients with NPC who received radiotherapy from March 2013 to November 2016 were enrolled and divided into the study group (n=68) and the control group (n=56) regarding the presence of RIOM. The risk factors of RIOM were evaluated by multivariate logistic regression.

A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration.

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer metastasis, facilitating the detachment and survival of cancer cells from the primary tumor site. However, few studies have focused on the role of anoikis in HNSC, especially on the prognosis.