Exploration of working memory retrieval stage for mild cognitive impairment: time-varying causality analysis of electroencephalogram based on dynamic brain networks.

Background: Mild Cognitive Impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and Alzheimer's disease (AD). Its management is crucial for it helps intervene and slow the progression of cognitive decline to AD. However, the understanding of the MCI mechanism is not completely clear.

The High Expression of PD-1 Defines A Subpopulation of Tfh Cells Responding to COVID-19 Vaccine in Humans.

Inactivated coronavirus disease 2019 (COVID-19) vaccines and receptor binding domain subunit (RBD-subunit) booster vaccination can induce effective humoral immune response. CD4+ T helper cells are essential in helping B cells and antibody response. However, the response of CD4+ T cells to booster vaccination, especially the virus-induced T follicular helper (Tfh) cells, needs to be better characterized.

Chronic unpredictable mild stress induces anxiety-like behavior in female C57BL/6N mice, accompanied by alterations in inflammation and the kynurenine pathway of tryptophan metabolism.

Chronic stress can impact brain function through various mechanisms, contributing to the development of anxiety disorders. Chronic unpredictable mild stress (CUMS) is a well-established model for studying the effects of chronic stress. This study assessed the impacts of different durations of CUMS on anxiety-like behavior, inflammation, and tryptophan metabolism in female C57BL/6N mice.

Assessment of Lumbar Muscles Activation in Patients with Unilateral Myofascial Pain Syndrome Based on High-density Surface Electromyography: A Preliminary Study.

Myofascial pain syndrome (MPS) is a chronic musculoskeletal pain characterized by myofascial trigger points (MTrPs), which are related to dysfunctional motor endplate. However, the changes in neuromuscular functions incurred by the MTrPs are still not well understood. High-density surface electromyography (HD-sEMG) provides a non-invasive method to identify motor endplates and quantify the muscle activity distribution.

Exploration of Brain Tumor Localization with High-density Electrocorticography.

The fast and accurate detection of brain tumor locations has always been a focus of research in the field of neuroscience. The main emphasis of this paper is to propose a potential intraoperative fast glioma localization technique. This study utilizes the rapid and high temporal resolution characteristics of electrocorticography to investigate the electroactive properties of the glioma region from a functional variability perspective and employs its differences to detect the location of the glioma.

Functional Connectivity of Salience Network Predicts Treatment Outcome for rTMS in Mild Cognitive Impairment.

Repetitive transcranial magnetic stimulation (rTMS) has been proved a potential therapeutic approach for improving the cognitive performance of patients with mild cognitive impairment (MCI). However, no biomarker is available for identifying who is most likely to respond to rTMS. The purpose of this study was to demonstrate that cognitive improvement after rTMS may be associated with functional connectivity of salience network at baseline.

Wrist EMG-based Gestures Recognition for Finger and Wrist Motions.

Gesture recognition is a relatively natural humanmachine interface (HMI). Electromyography (EMG) based gesture recognition methods have been extensively investigated in upper limb prostheses as a special HMI, in which EMG sensors are mostly mounted on the proximal part of the forearm. However, for more general applications beyond upper-limb prosthetics, the wrist may be a more suitable position for more intuitive HMIs, in which independent finger movements in addition to wrist gestures can be realized.

Signal Characteristics, Motor Cortex Engagement, and Classification Performance of Combined Action Observation, Motor Imagery and SSMVEP (CAMS) BCI.

Motor imagery (MI)-based Brain-Computer Interfaces (BCIs) have shown promise in engaging the motor cortex for recovery. However, individual responses to MI-based BCIs are highly variable and relatively weak. Conversely, combined action observation (AO) and motor imagery (MI) paradigms have demonstrated stronger responses compared to AO or MI alone, along with enhanced cortical excitability.

Continuous Estimation of Hand Kinematics from Electromyographic Signals based on Power-and Time-Efficient Transformer Deep Learning Network.

Surface Electromyographic (sEMG) signals contain motor-related information and therefore can be used for human-machine interaction (HMI). Deep learning plays an important role in extracting motor-related information from sEMG signals. However, most studies prioritize model accuracy without sufficient consideration of model efficiency, including the model size, power consumption, and the computational speed of the model.

A Vascularized Multilayer Chip Reveals Shear Stress-Induced Angiogenesis in Diverse Fluid Conditions.

Tissues larger than 400 μm in size lacking microvascular networks cannot survive for long periods of time in vitro. The development of microfluidic technology provides an efficient research tool for constructing microvascular models in vitro. However, traditional single-layer microfluidic chips faced the limitation of spatial layout and could not provide diverse fluidic environments within a single chip.

Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress.

Background: During medium- to long-duration spaceflights, real-time microgravity can increase the health risks of astronauts. In particular, the disruption of intestinal homeostasis is closely related to other health problems, and it is necessary to monitor related treatment strategies. Ginseng is a well-known Chinese herbal medicine often used to maintain health.

Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats.

Background: Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential differences between sexes. This study aims to investigate sex-specific differences in cognitive function under sleep deprivation using reward-based operant conditioning tasks.

Chronic unpredictable mild stress-induced anxiety is linked to inflammatory responses and disruptions in tryptophan metabolism in male C57BL/6N mice.

Chronic stress can affect brain function through various mechanisms, leading to the development of anxiety disorders. The chronic unpredictable mild stress (CUMS) is a classic model of chronic stress. This study evaluated the effects of different durations of CUMS on anxiety-like behavior, inflammation, and tryptophan metabolism in C57BL/6N mice.

Causal role of common autoimmune diseases in interstitial cystitis/bladder pain syndrome: Mendelian randomization (MR) study.

Observational studies suggest that interstitial cystitis/bladder pain syndrome (IC/BPS) indices might be influenced by autoimmune diseases (AIDs), though it is difficult to infer causal relationships based on observational data due to risk of residual confounding. We utilized Mendelian randomization (MR) to explore causal relevance of multiple AIDs on IC/BPS. Our bidirectional two-sample MR analysis was based on summary statistics from the most recent and comprehensive genome-wide association studies.

Induction Immunochemotherapy Followed by Hypo-Fractionated Radiotherapy in Unresectable Stage III Non-Small Cell Lung Cancer.

Purpose: To evaluate the efficacy and safety of induction immunochemotherapy followed by hypo-fractionated radiotherapy (Hypo-RT) for locally advanced unresectable non-small cell lung cancer (LA-NSCLC).

Methods: This retrospective analysis involved the data of 35 patients with unresectable stage III LA-NSCLC receiving immunotherapy plus Hypo-RT from January 1, 2019, to December 31, 2023. At least 2 cycles of induction immunochemotherapy were initially administered, followed by a definitive Hypo-RT at 4 Gy per fraction.

Mechanical and Thermal Properties of 3D-Printed Continuous Bamboo Fiber-Reinforced PE Composites.

Continuous fibers with outstanding mechanical performance due to the continuous enhancement effect, show wide application in aerospace, automobile, and construction. There has been great success in developing continuous synthetic fiber-reinforced composites, such as carbon fibers or glass fibers; however, most of which are nonrenewable, have a high processing cost, and energy consumption. Bio-sourced materials with high reinforced effects are attractive alternatives to achieve a low-carbon footprint.

The Antibacterial Activity and Mechanisms of a Mixed Bio-Preservative on the Stains in Crab Roe Sauce.

Crab roe sauce (CRS) is prone to spoilage due to microbial contamination. Therefore, this study aimed to investigate the inhibitory effects and mechanisms of a mixed bio-preservative (0.025% ε-polylysine hydrochloride (ε-PL) + 0.

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite .

infects nucleated cells of warm-blooded animals and cause zoonotic toxoplasmosis. Lysine lactylation, as a novel post-translational modification, is essential for epigenetic regulation and cellular processes, and proteomic analyses have shown that lactylated proteins are involved in a wide range of biological processes including energy metabolism, gene regulation, and protein biosynthesis. Additionally, protein lactylation is prevalent in , while its regulatory mechanisms have not been fully understood.

In Vivo Time-Resolved Single-Cell RNA-Seq Reveals Chemotherapy-Induced Transcriptional Dynamics in Tumor Infiltrating Lymphocytes.

Single-cell RNA sequencing (scRNA-seq) using metabolic RNA labeling enables detailed analysis of dynamic gene expression within single cells. However, most studies are limited to in vitro settings, restricting the exploration of in vivo transcriptomic dynamics. To address this, we developed scDyna-seq, a time-resolved scRNA-seq method for in vivo applications using 4-thiouridine (4sU) labeling.

MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis.

Trichinella spiralis (T. spiralis) has been reported to induce inflammation, which can cause immune system dysregulation. Myeloid differentiation primary response gene 88 (MyD88) is implicated in inflammation signalling pathways.

Glioma-induced neural functional remodeling in the hand motor cortex: precise mapping with ECoG grids during awake craniotomy-experimental research.

Background: The dilemma of achieving 'onco-functional balance' in gliomas affecting the motor cortex highlights the importance of functionally-guided resection strategies. While accurate mapping of eloquent areas often requires frequent electrical stimulation, this practice can lead to side effects like seizures and postoperative deficits. To enhance safety in functional mapping, we studied how gliomas impact hand movement areas and assessed the effectiveness of cortical electrical activity for functional mapping in this setting.

Neuroprotective role of Da Qin Jiu decoction in ischemic stroke: Mitochondrial rescue through PI3K/Akt-mediated UPR activation.

Ethnopharmacological Relevance: Ischemic stroke (IS) is a highly debilitating neurological condition with limited treatment options and suboptimal outcomes. The traditional Chinese medicine formula Da Qin Jiu Decoction (DQJD) has been widely used for its neuroprotective effects. However, its potential mechanisms of action in IS remain unclear.

Molecular Uranium Dioxide-Mediated CO Photoreduction.

The reduction of CO mediated by transition metals has garnered significant interest, yet little is known about the reduction of CO using f-element compounds. Herein, the reduction of CO to CO by tetravalent uranium (U) compound UO is investigated via matrix isolation infrared spectroscopy and quantum chemical study. Our results reveal that a stable carbonate intermediate OUCO () can be prepared at low temperatures (4-12 K).

Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.

This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia-T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau.

Integrative proteomic analysis reveals the potential diagnostic marker and drug target for the Type-2 diabetes mellitus.

Objective: The escalating prevalence of Type-2 diabetes mellitus (T2DM) poses a significant global health challenge. Utilizing integrative proteomic analysis, this study aimed to identify a panel of potential protein markers for T2DM, enhancing diagnostic accuracy and paving the way for personalized treatment strategies.

Methods: Proteome profiles from two independent cohorts were integrated: cohort 1 composed of 10 T2DM patients and 10 healthy controls (HC), and cohort 2 comprising 87 T2DM patients and 60 healthy controls.