Task-augmented cross-view imputation network for partial multi-view incomplete multi-label classification.

In real-world scenarios, multi-view multi-label learning often encounters the challenge of incomplete training data due to limitations in data collection and unreliable annotation processes. The absence of multi-view features impairs the comprehensive understanding of samples, omitting crucial details essential for classification. To address this issue, we present a task-augmented cross-view imputation network (TACVI-Net) for the purpose of handling partial multi-view incomplete multi-label classification.

Stereoselective Synthesis of Olefins from β-Hydroxy NHPI Esters.

Herein, we describe a highly stereoselective method to access a single olefin isomer from readily available β-hydroxy -hydroxyphthalimide (NHPI) esters. Depending on the configuration of the precursor ( or ), either the or olefin is prepared selectively under Lewis acid-promoted conditions. Without involving radical chemistry, a β-lactone is proposed as the key intermediate in this decarboxylative olefination.

UV/blue-light-blocking polylactide films derived from bio-sources for food packaging application.

Transparent biodegradable packaging materials capable of blocking the broad-spectrum of UV and blue light (200-500 nm) are crucial for packaging of light-sensitive food. This study offers a fully bio-based solution based on polylactide and natural light absorbers, aloe-emodin (AE) and riboflavin (RF), whose combined UV-vis absorption spectrum covers all the light between 200 and 500 nm. AE and RF were bonded to polylactide chains by serving as initiators for the ring-opening polymerization of lactide, resulting in the synthesis of light-blocking polylactides, PLA-E and PLA-R.

Effects of life rules on mental health and behavioral problems among adolescent and youth students: A survey after the lifting of COVID-19 restrictions in China.

Objective: To explore the impact of life rules (including individual's life habits and life patterns, such as diet, sleep, and learning styles) on mental health and behavioral problems among adolescent and youth students after the lifting of COVID-19 restrictions in Sichuan, China and analyze the influencing factors of life rules.

Methods: An online survey was conducted in middle schools, high schools, colleges and universities in Sichuan Province, China, from December 14, 2022, to February 28, 2023. Demographic information, COVID-19 epidemic-related questions, behavioral and mental health information were collected.

Novel role of general transcript factor IIH subunit 2 (GTF2H2) in the development and sex disparity of hepatocellular carcinoma.

Sex disparity is a hepatocellular carcinoma (HCC) hallmark, demonstrating aggressiveness and mortality more frequently in men than in women. However, the components of its basis remain largely unknown. It was identified in HCC frequent loss of heterozygosity of general transcript factor IIH subunit 2 (GTF2H2), a potential estrogen pathway gene.

π-Extended Heli(aminoborane)s with Highly Bright Circularly Polarized Luminescence and Narrowband Emission.

Helical molecular carbons (HMCs) possess high absorption/luminescence dissymmetry factors (g/g) and significant luminescence quantum yield (Φ), resulting in a high circularly polarized luminescence (CPL) brightness (B), which is essential for the development of CPL materials for practical applications. Herein, we designed and synthesized a series of boron-nitrogen (BN)-doped HMCs, named π-extended heli(aminoborane)s (E[10]HAB-A, E[10]HAB-B and E[10]HAB-C), consisting of laterally π-extended [10]helicene skeleton with alternating N and B atoms at the inner rim. The aromaticity, electronic structures, and photophysical properties of E[10]HAB-A/B/C were systematically investigated through experiments and theoretical calculations.

Barrier properties of polylactic acid to binary aqueous solution systems.

The barrier properties of polylactic acid (PLA) to four typical binary aqueous solutions with sodium chloride (NaCl), sodium lauryl polyoxyethylene ether sulfate (SELS), acetic acid (AcOH), and ethanol (EtOH) as solute respectively were studied by investigating the adhesion work from contact angle and surface tension, measuring the water diffusion coefficient (D) from time-resolved infrared spectroscopy (TRIS), and detecting the solute permeation rate (P) from permeation. The results illustrate that, among the four solutions and the single water, the single water shows the biggest adhesion work to the PLA, being 89.2 J/m, and the interaction between the solution and PLA is closely correlated with the structure of the solution.

Role of the nucleotide excision repair function of CETN2 in the inhibition of the sensitivity of hepatocellular carcinoma cells to oxaliplatin.

Resistance to platinum-based chemotherapy agents like oxaliplatin (OXA) poses significant challenges in the treatment of cancers such as hepatocellular carcinoma (HCC). Centrin 2 (CETN2), which functions in nucleotide excision repair (NER) of DNA damage, is overexpressed in HCC. We investigated the potential role of CETN2 in modulating the sensitivity of HCC cells to OXA.

A single-crystal 3D Zn-tetrathiolate connected metal-organic framework.

Due to thiolate's fast and robust coordination, crystallographically resolved thiolate-ligated metal-organic frameworks (MOFs) are hard to obtain. Following the previous success of the masked synthetic strategy to achieve single-crystal Pb-thiolate connected MOFs, thioester-protected hexathiotriphenylene (HVaTT) was employed in this work to assemble with a Zn(II) centre to yield the first example of a first-row transition-metal based crystallographically resolved metal-tetrathiolate connected MOF, HTT-Zn. HTT-Zn features a 3D anionic framework connected by tetrahedral [ZnS] nodes with 3-fold interpenetration and windmill-like topology.

Design Strategy of PepNzymes-SH for an Emerging Catalyst with Serine Hydrolase-Like Functionality.

Serine hydrolases, as a class of green catalysts with hydrolytic and dehydrating activities, hold significant application value in the fields of biosynthesis and organic synthesis. However, practical applications face numerous challenges, including maintaining enzyme stability and managing usage costs. PepNzymes-SH, an emerging green catalytic material with enzyme-like activity, overcomes the operational limitations of natural enzymes and holds great promise as a substitute for hydrolases.

Lung cancer screening program quality indicators - review & recommendations - An International Association for the Study of Lung Cancer Delphi process study.

Introduction: Lung cancer screening (LCS) using low-dose-computed tomography reduces lung cancer mortality in high-risk individuals. Evaluating and monitoring LCS programs are important to ensure and improve quality, efficiency and participant outcomes. There is no agreement on LCS quality indicators (QIs).

A shikimic acid derived carbon dots (SACNDs-FITC) for multi-modal detection and removal of Hg: Probe design, sensing performance, and applications in food analysis.

The first shikimic acid derived fluorescent carbon dots (SACNDs-FITC) for multi-modal detection and simultaneous removal of Hg is revealed. The fluorescence of SACNDs-FITC centered at 520 nm can be selectively quenched by Hg, while the emission centered at 420 nm remains constant which can be used for self-calibration. Naked-eye distinguishable color change from yellow to colourless under daylight and from green to blue under UV light could be observed for SACNDs-FITC in the real-time detection of Hg.

Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics.

Large case-control genome-wide association studies (GWASs) have detected loci associated with insomnia, but how these risk loci confer disease risk remains largely unknown. By integrating brain protein quantitative trait loci (pQTL) (N = 376, N = 152) and expression QTL (eQTL) (N = 452) datasets, with the latest insomnia GWAS summary statistics (N = 109,548, N = 277440), we conducted proteome/transcriptome-wide association study (PWAS/TWAS) and Mendelian randomization (MR) analysis, aiming to identify causal proteins involving in the pathogenesis of insomnia. We also explored the bi-directional causality between insomnia and several common diseases.

Evidence for a causal link between lipoprotein (a) and mental disorders: A retrospective and Mendelian randomization study.

Study Objectives: Lipoprotein (a) [Lp(a)] is a biomarker of atherosclerotic cardiovascular disease, but its role in mental disorders is controversial. Our study aimed to explore the causality between Lp(a) levels and mental disorders by combining retrospective and Mendelian randomization (MR) studies.

Methods: All genome-wide association study datasets used in the MR study were obtained from UK Biobank, FinnGen, and the Psychiatric Genomics Consortium.

Evaluation and analysis of respiratory infectious disease prevention behaviors in older adults.

Background: Respiratory infectious diseases (RIDs) are a global public health problem, characterized by strong infectivity, high transmissibility, and a high incidence in the population. This study aimed to explore RID prevention behaviors among older adults and analyze their influencing factors.

Methods: A cross-sectional study was conducted to examine RID prevention behaviors among 2219 Chinese older adults.

3D cross-linked structure of dual-active site CoMoO nanosheets@graphite felt electrode for vanadium redox flow battery.

Transition metal oxides (TMOs) can accelerate the sluggish kinetics of vanadium redox reaction, but face challenges like limited active sites and difficulties in nanometerization, highlighting the urgent need for new TMO electrocatalysts for vanadium redox flow battery (VRFB). CoMoO features high electrochemical activity, numerous redox sites, flexible control, and short electron pathways. Herein, a high catalytic and super stable graphite felt electrode modified in situ with network cross-linking CoMoO nanosheets (CoMoO@GF) was prepared via hydrothermal and heat treatment method to enhance VRFB performance.

Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine.

Introduction: People who inject drugs experience poor health and social outcomes which improve with opioid agonist therapies like methadone, yet provider stigma may influence healthcare utilization. In Ukraine, integrating methadone into primary care centers (PCCs) provides an opportunity to examine provider stigma and its impact on patient outcomes.

Methods: This sub-analysis included patients randomized to receive methadone in PCCs as part of an implementation trial in which the control group received methadone in specialty addiction clinics in Ukraine.

Effect of poly(vinyl alcohol)-g-poly(lactic acid) on the oxygen barrier performance of poly(lactic acid)-based film.

In order to improve the oxygen barrier performance of poly(lactic acid) (PLA), a simple and economical melt blending method was chosen and poly(vinyl alcohol) (PVOH) with excellent oxygen barrier was used as the reinforcing phase to meet high oxygen needs. To improve compatibility, PLA was grafted onto PVOH through L-LA ring opening polymerization to get poly(vinyl alcohol)-graft-poly(lactic acid) (PVOH-g-PLA). The films with high oxygen barrier performance were prepared by blending PLA with PVOH-g-PLA.

Olaparib and Radiotherapy Induce Type I Interferon- and CD8+ T Cell-Dependent Sensitization to Immunotherapy in Pancreatic Cancer.

PARP inhibitors sensitize pancreatic ductal adenocarcinoma (PDAC) to radiation by inducing DNA damage and replication stress. These mechanisms also have the potential to enhance radiation-induced type I interferon (T1IFN)-mediated antitumoral immune responses. We hypothesized that the PARP inhibitor olaparib would also potentiate radiation-induced T1IFN to promote antitumor immune responses and sensitization of otherwise resistant PDAC to immunotherapy.

A bibliometric analysis of immunotherapy for atherosclerosis: trends and hotspots prediction.

Introduction: An increasing number of studies have demonstrated that immunotherapy may play a significant role in treating Atherosclerosis and has emerged as a promising therapy in this field. The aim of this study is to provide a comprehensive perspective through bibliometric analysis and investigate the existing hotspots and frontiers.

Methods: This study searched records from Web of Science, PubMed, and Scopus from January 1, 1999, to May 27, 2023.

The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.

Background: Tumor-associated tertiary lymphoid structures (TLSs) are functional immune-responsive aggregates, which have been reported to be associated with better prognosis in various tumors. However, their exact characteristics and prognostic value in extramammary Paget's disease (EMPD) remain unknown.

Objective: To explore the features of TLSs in EMPD and their association with clinicopathological characteristics.

Adjuvant immunotherapy does not improve survival in non-small cell lung cancer with major/complete pathologic response after induction immunotherapy.

Background: In patients with resectable non-small cell lung cancer (NSCLC), immune checkpoint inhibitor (ICI)-based regimens in both neoadjuvant and perioperative settings have demonstrated a survival benefit. However, no previous study has compared the efficacy between pure neoadjuvant and perioperative approaches, especially in patients who achieve a substantial pathologic response.

Methods: In this retrospective study, patients with clinical stage II-IIIB NSCLC who achieved either a major pathologic response (MPR) or pathologic complete response (pCR) after induction ICI plus chemotherapy, followed by resection, between 2019 and 2023 were identified from multicenter databases.