Publications by authors named "Jiang Lin Zheng"
Article Synopsis
- The study highlights the importance of overcoming chemotherapy resistance to temozolomide (TMZ) in glioblastoma multiforme (GBM) treatment, revealing the long non-coding RNA JPX as a significant factor.
- JPX is found to be upregulated in GBM tissues and is associated with poor patient prognosis, driving cancer cell proliferation, resistance to TMZ, and enhanced DNA repair mechanisms.
- The mechanism involves JPX stabilizing and increasing the expression of PDK1 mRNA, interacting with the m6A demethylase FTO, revealing JPX's potential as a new therapeutic target for improving GBM treatment outcomes.
Heat stress-induced reductions in milk yield and the dysfunction of mammary glands are economically important challenges that face the dairy industry, especially during summer. The aim of the present study is to investigate the effects of heat stress on mitochondrial function by using dairy cow mammary epithelial cells (DCMECs) as an in vitro model. Live cell imaging shows that the mitochondria continually change shape through fission and fusion.
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