Publications by authors named "Jiang Hong-Lei"
Article Synopsis
- The study investigates the role of MafB in the growth of hepatocellular carcinoma (HCC), highlighting its significant increase in HCC tissues compared to normal tissues.
- Overexpression of MafB boosts HCC cell proliferation by directly regulating Cyclin D1, a crucial protein for cell cycle progression, while reducing MafB inhibits growth.
- The research establishes a new regulatory pathway between MafB and Cyclin D1 in HCC, suggesting that disruptions in this pathway contribute to cancer cell proliferation.
Background/aims: Hepatocellular carcinoma (HCC) represents the most common type of liver cancer. DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1), an atypical member of the nuclear receptor family due to lack of classical DNA-binding domains, has been known for its fundamental roles in the development, especially in the sex determination and steroidogenesis. Previous studies also showed that DAX-1 played a critical role in endocrine and sex steroid-dependent neoplasms such as adrenocortical, pituitary, endometrial, and ovarian tumors.
View Article and Find Full Text PDFMultiple studies have shown that steroid receptor coactivator-3 (SRC-3) is upregulated and promotes cell proliferation in several human cancers, including breast, lung, and prostate carcinoma. However, its molecular determinants remain largely unexplored. In the current study, by way of informatics software, we found that MicroRNA-195 (miR-195) could negatively regulate protein levels of SRC-3 through targeting its 3'-untranslated region (3'-UTR) in hepatocellular carcinoma (HCC) cells.
View Article and Find Full Text PDFPHA665752 (PHA), a selective small molecule c-Met Inhibitor, potently inhibited HGF-stimulated and constitutive c-Met phosphorylation, as well as HGF and c-Met-driven phenotypes of a variety of tumor cells including hepatocellular carcinoma cells. However, these effects were impaired in c-Met-deficient cancer cells. In the present study, we investigated the potential anti-human c-Met-deficient hepatocellular carcinoma effects of Celastrol, a novel triterpene, and its combination with PHA.
View Article and Find Full Text PDFArticle Synopsis
- A new compound called levantilide C, a 20-membered macrolide, was discovered from a Micromonospora strain found in coastal waters off Chiloe, Chile.
- The chemical structure of levantilide C was determined using NMR analysis.
- Additionally, two known indole derivatives were isolated from the same strain, and levantilide C showed moderate activity in inhibiting the growth of various tumor cell lines.
Aim: To investigate the role of anti-perforin neutralizing antibody in viral myocarditis.
Methods: We divided 45 Balb/c mice randomly into 3 groups, a normal control group, a control group inoculated with coxsackie virus B3, and a group inoculated with anti-perforin neutralizing antibody. The second group was inoculated with 0.