One-step colorimetric immunosensing of foodborne bacteria using static magnet driven magnetophoretic separation and dual noble metal decorated magnetic nanobeads.

Background: Immunomagnetic separation is essential for screening pathogenic bacteria to prevent food poisoning. However, free immunomagnetic nanobeads (IMNBs) coexist with IMNB-bacteria conjugates (IBCs) after traditional immunomagnetic separation resulting in the infeasibility for IMNBs on IBCs to further act as signal label in bacterial detection. Although we have demonstrated that magnetophoretic separation at a high flowrate could separate IBCs from IMNBs, partial IMNBs were still found with IBCs due to chaotic flows and resulted in inevitable interferences.

Magnetic cationic covalent organic framework for efficient enrichment and detection of phenolic endocrine disruptors in foodstuffs.

Endocrine disrupting chemicals (EDCs) have received significant attention in the food field due to their potential health risks. Herein, we proposed a novel core-shell structure magnetic cationic covalent organic framework (EB-DHTA-iCOF@FeO) designed for the efficient enrichment of trace-level EDCs in foodstuffs and analyzed using HPLC-MS/MS. Due to the phenolic EDCs structure possessing hydroxyl functional groups which become protonated under alkaline conditions, resulting in the formation of negatively charged anions.

Safety, Tolerability, and Pharmacokinetics of SC1011 (Sufenidone), a Novel Antifibrotic Small Molecule, in Phase 1 Studies in Healthy Subjects.

SC1011 (sufenidone) is a novel pyridone derivative with therapeutic potential for idiopathic pulmonary fibrosis (IPF). Two Phase 1 studies evaluated the safety and pharmacokinetics of single (SAD) and multiple ascending doses (MAD) of SC1011 immediate-release (IR) and modified-release (MR) oral formulations in healthy adult subjects. In Phase 1a, subjects were randomized to receive oral SC1011 IR or placebo in SAD (50 mg-300 mg) or MAD (100 mg and 200 mg) twice daily for 7 days.

Noninvasive Quantification of Hepatic Steatosis Using Ultrasound-Derived Fat Fraction (CHESS2303): A Prospective Multicenter Study.

Ultrasound-derived fat fraction (UDFF) is designed to assess the hepatic fat content quantitatively. A multicenter study that verifies the diagnostic performance of UDFF for detecting hepatic steatosis has not yet been reported. This study aimed to evaluate the performance of UDFF for diagnosing and grading hepatic steatosis.

Automated segmentation by SCA-UNet can be directly used for radiomics diagnosis of thymic epithelial tumors.

Background: Automatic segmentation of thymic lesions in preoperative computed tomography (CT) images is crucial for accurate diagnosis but remains time-consuming. Although UNet is widely used in medical imaging, its performance is limited by the inherent drawbacks of convolutional neural networks (CNNs), such as restricted receptive fields and limited global context modeling, which affect segmentation efficiency.

Method: 712 patients with mediastinal lesions admitted to Shanghai General Hospital between October 2014 and January 2023 were included in the study.

Impact of Nasal Glucocorticoid Therapy on Exhaled Nitric Oxide and Symptom Relief in Chronic Rhinosinusitis with Nasal Polyps: A Randomized Prospective Study.

Introduction Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a widespread inflammatory disease, classified into Eosinophilic (EosCRSwNP) and non-Eosinophilic (non-EosCRSwNP) types. Nitric oxide (NO) plays a role in pathophysiological processes, with changing levels in airway diseases like asthma and CRS. Intranasal corticosteroids (INCS) are first-line treatments for CRSwNP, providing anti-inflammatory and immunomodulatory effects pre- and post-endoscopic sinus surgery (ESS).

[Arbuscular mycorrhizal fungi improve physiological metabolism and ameliorate root damage of under cadmium stress].

Soil cadmium pollution can adversely affect the cultivation of the ornamental plant, . Upon cadmium contamination of the soil, the growth of . is impeded, and it may even succumb to the toxic accumulation of cadmium.

Development and validation of the Parent-Reported Indicator of Developmental Evaluation for Chinese Children (PRIDE) tool.

Background: Developmental delay (DD) poses challenges to children's overall development, necessitating early detection and intervention. Existing screening tools in China focus mainly on children with developmental issues in two or more domains, diagnosed as global developmental delay (GDD). However, the recent rise of early childhood development (ECD) concepts has expanded the focus to include not only those with severe brain development impairments but also children who lag in specific domains due to various social-environmental factors, with the aim of promoting positive development through active intervention.

Tailoring the Structural Evolution of Multi-Electron Redox Conversions via Strong Selenium-Carbon Interaction for Robust Aqueous Copper-Ion Batteries.

Aqueous metal-selenium batteries based on chalcogenide cathodes, despite their multi-electron conversion-type redox reactions and rapid kinetics, suffer from short lifespans and unclear capacity degradation mechanisms. The interfacial interactions between doped carbon and chalcogenides correlate closely with the electrochemical structural evolution. Hence, flower-like CuSe wrapped with ultrathin N-doped carbon layer (CuSe@N-C) is synthesized via a simple γ radiation-pyrolysis route for the first time.

Global burden of disease for musculoskeletal disorders in all age groups, from 2024 to 2050, and a bibliometric-based survey of the status of research in geriatrics, geriatric orthopedics, and geriatric orthopedic diseases.

Background: Orthopaedic diseases in the elderly pose a significant disease burden, and the number of research papers on the subject is increasing every year.

Methods: The GBD database was used to analyze the global disease burden of musculoskeletal disorders in all age groups from 2024 to 2050. The source for bibliometrics was the WoSCC SCI-E database.

Biochar chemical-looping gasification for hydrogen-rich syngas production in solid-solid reaction: O, H and CaO of carbide slag effect NiFeO oxygen carrier.

Biomass chemical-looping gasification represents a promising technology for the production of hydrogen-rich syngas, wherein the yield of gas is contingent upon the rate of solid-solid reactions. In this study, the incorporation of carbide slag as an oxygen carrier, hydrogen carrier, and in-situ carbon capture agent, as well as the modification of the synthesis method for the NiFeO oxygen carrier, were specifically targeted to enhance the solid-solid reaction activity. The results indicate that the reactivity can be significantly improved by synthesizing NiFeO using the sol-gel method with varying ratios of citric acid.

Oxidative stress mechanisms underlying temporal hormesis effects induced by binary antibiotic mixtures on Scenedesmus obliquus.

The hormesis effect has gradually become a research focus in environmental science and toxicology due to its unique phenomenon of low-concentration stimulation and high-concentration inhibition. The combined toxicity of antibiotics and their regulatory effects on microorganisms are areas that warrant significant attention. In this study, doxycycline hydrochloride (DXC), sulfamethoxazole (SMX) and sulfamethazine (SMZ) were used as the research objects, and Scenedesmus obliquus was used as the indicator organism to study their toxicity and action laws at different exposure times (4d and 8d).

Feasibility and acceptability of implementing the Global Scales for Early Development (GSED) package for children 0-3 years across three countries.

Background: To assess the neurodevelopment of children under three years, a multinational team of subject matter experts (SMEs) led by the World Health Organization (WHO) developed the Global Scales for Early Development (GSED). The measures include (1) a caregiver-reported short form (SF), (2) a directly administered long form (LF), and (3) a caregiver-reported psychosocial form (PF). The feasibility objectives of this study in Bangladesh, Pakistan, and the United Republic of Tanzania were to assess (1) the study implementation processes, including translation, training, reliability testing, and scheduling of visits and (2) the comprehensibility, cultural relevance, and acceptability of the GSED measures and the related GSED tablet-based application (app) for data collection for caregivers, children, and assessors.

An unusual transfusion-dependent hemoglobin H disease caused by a novel complex inverted duplication involving the α-globin regulatory elements and α-thalassemia--SEA deletion.

Four multi-species conserved sequences (MCSs) are important enhancers which affect α-globin expression. Deletions of MCS can cause α-thalassemia. So far, duplication of MCS has never been reported to account for thalassemia.

Harnessing photosynthesis for materials, devices, and environmental technologies.

Photosynthetic organisms convert solar light into chemical energy through the process of photosynthesis. The employment of photosynthetic organisms in novel materials and devices provides them with a solar-powered and sustainable functionality. In general, photosynthesis utilizes light, water, and CO to generate various organic compounds while releasing secondary valuable products such as O, extracellular electrons, carbohydrates, or H.

Fractional flow reserve- and intravascular ultrasound-guided strategies for intermediate coronary stenosis and low lesion complexity in patients with or without diabetes: a post hoc analysis of the randomised FLAVOUR trial.

Background: A recent randomised trial demonstrated fractional flow reserve (FFR) guidance for percutaneous coronary intervention (PCI) was non-inferior to intravascular ultrasound (IVUS) guidance regarding clinical outcomes, with a lower frequency of PCI.

Aims: We sought to evaluate the prognosis of FFR versus IVUS guidance for PCI of intermediate coronary artery stenosis and low lesion complexity in diabetic and non-diabetic patients.

Methods: This study is a prespecified post hoc analysis from the FLAVOUR trial.

Application of nanomaterials in precision treatment of lung cancer.

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by high mortality rates due to its aggressive nature, metastatic potential, and drug resistance. Despite advancements in conventional therapies, their efficacy is often limited by systemic toxicity, poor tumor specificity, and the emergence of resistance mechanisms. Nanomedicine has emerged as a promising approach to address these challenges, leveraging the unique physicochemical properties of nanomaterials to enhance drug delivery, reduce off-target effects, and enable combination therapies.

Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio: Post Hoc Analysis From FLAVOUR Trial.

Background: Coronary physiology measured by fractional flow reserve (FFR) is superior to angiography for assessing the efficacy of percutaneous coronary intervention (PCI). Yet, the clinical adoption of post-PCI FFR is limited. Murray law-based quantitative flow ratio (μQFR) may represent a promising alternative, as it can quickly compute FFR from a single angiographic view.

Prognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis.

Background: The association between coronary microcirculation and clinical outcomes in patients with intermediate stenosis remains unclear.

Objectives: The aim of this study was to assess the prognostic significance of angiography-derived index of microcirculatory resistance (angio-IMR) in patients with intermediate coronary stenosis.

Methods: This post hoc analysis included 1,658 patients from the FLAVOUR (Fractional Flow Reserve and Intravascular Ultrasound for Clinical Outcomes in Patients with Intermediate Stenosis) trial, with angio-IMR measured in each vessel exhibiting intermediate stenosis.

A novel technique for rapid localization of pulmonary nodules on-site in operating room followed by lung resection: a case series.

Background: The localization of pulmonary nodules is crucial for surgical intervention. However, a safe, simple, and efficient method remains elusive. This study aims to evaluate the safety and feasibility of a newly developed preoperative localization method for pulmonary nodules called Rapid Localization of Pulmonary Nodules On-Site (RLPN-OS).

Modal focal adaptive optics for Bessel-focus two-photon fluorescence microscopy.

Adaptive optics (AO) improves the spatial resolution of microscopy by correcting optical aberrations. While its application has been well established in microscopy modalities utilizing a circular pupil, its adaptation to systems with non-circular pupils, such as Bessel-focus two-photon fluorescence microscopy (2PFM) with an annular pupil, remains relatively uncharted. Herein, we present a modal focal AO (MFAO) method for Bessel-focus 2PFM.

An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms.

Contact hypersensitivity and atopic dermatitis are pervasive inflammatory skin diseases with similar symptoms, and their global prevalence is steadily increasing. Many compounds and biotics have been developed to target molecules critical to the etiology or pathogenesis of contact hypersensitivity and atopic dermatitis. However, these molecules are sometimes ineffective or lose their potency during the therapeutic course.

Effect of ultrasonic-assisted enzymatic extraction on proso millet bran protein: extraction rate, structural and functional properties.

Background: Proso millet bran protein (PMBP), derived from agricultural by-products, possesses high nutritional value, despite its challenging extraction process. The present study proposes an extraction method for PMBP using ultrasound-assisted cellulase technology (UAE), and optimizes the process parameters. Non-waxy (N-PMBP) and waxy (W-PMBP) PMBPs, extracted through alkaline solubilization and acid precipitation (conventional treatment, CT), served as control groups to assess the impact of UAE on the structure and functionality of PMBP, as well as the distinctions between N-PMBPs and W-PMBPs.

Clinical applications of nanoprobes of high-resolution imaging.

Currently, the primary imaging methods used in clinical diagnosis are X-ray, computed tomography (CT), ultrasound, magnetic resonance imaging (MRI), PET-CT, etc. The sensitivity and accuracy of these imaging methods bring many difficulties in clinical diagnosis; at the same time, CT, X-ray, PET-CT, etc. can cause radiation to the human body; some invasive operations of the gold standard bring much pain to the patients.