Publications by authors named "Jiang D"
Birefringent crystals, which can modulate and polarize light, play a vital role in the development of optical sensors and optoelectronic devices. Herein, we synthesized a new birefringent crystal [(CNH)(HIO)(HIO)(IO)] with large birefringence by integrating the large π-conjugated 4,4'-bipyridine group with two types of iodates anions ([IO] and [HIO]) characterized by high polarizability anisotropy and strong stereochemically active lone pairs (SCALP). The crystal exhibits a large measured birefringence of 0.
View Article and Find Full Text PDFSimulation of the continuous time random walk using subordination schemes.
Phys Rev E
September 2024
The continuous time random walk model has been widely applied in various fields, including physics, biology, chemistry, finance, social phenomena, etc. In this work, we present an algorithm that utilizes a subordinate formula to generate data of the continuous time random walk in the long time limit. The algorithm has been validated using commonly employed observables, such as typical fluctuations of the positional distribution, rare fluctuations, the mean and the variance of the position, and breakthrough curves with time-dependent bias, demonstrating a perfect match.
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- This systematic review examined the impact of therapeutic drug monitoring (TDM) for TNF-α inhibitors in immune-mediated inflammatory diseases (IMIDs) using real-world evidence, as previous meta-analyses from randomized controlled trials might not reflect actual clinical practices.
- The review included 24 cohort studies, primarily focusing on infliximab, showing that proactive TDM significantly improved clinical remission and reduced complications for inflammatory bowel diseases (IBDs), while the benefits for rheumatic diseases were inconclusive.
- The findings suggest that proactive TDM for TNF-α inhibitors, especially infliximab, enhances treatment effectiveness, safety, and reduces risk of immunogenicity in IBDs, though its advantages in
This research aimed to investigate the effects of dietary fructooligosaccharides (FOS) on attenuating the Aeromonas hydrophila (A. hydrophila)-induced oxidative stress and apoptosis in blunt snout bream Megalobrama amblycephala. Fish were divided into three groups as follows: C1 (Control), T1 (A.
View Article and Find Full Text PDFGlobal risk dynamics of Borrelia miyamotoi in the context of climate change.
Environ Microbiol
October 2024
The impact of Borrelia miyamotoi on human health, facilitated by the expanding geographical distribution and increasing population of Ixodes ticks, remains obscure in the context of global climate change. We employed multiple models to evaluate the effect of global climate change on the risk of B. miyamotoi worldwide across various scenarios.
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- NONO is a nuclear protein that plays a role in different biological processes, including the immune response to viruses, particularly in pigs.
- This study found that swine NONO (sNONO) can inhibit replication of the porcine reproductive and respiratory syndrome virus (PRRSV) by boosting the expression of IFN-β, which is crucial for antiviral responses.
- The research shows that NONO works by forming a complex with the PRRSV N protein and the IRF3 protein, enhancing IFN-β production and countering PRRSV's negative effects on the immune signaling pathway.
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- Osteoporosis is a major global health issue due to low bone density and an increased risk of fractures.
- Macrophage polarization, specifically the balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages, significantly affects bone health and metabolism.
- The review explores how these macrophage types influence osteoporosis development, assesses current therapies targeting their polarization, and suggests future research directions for better osteoporosis management.
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- Recent studies showed that skin samples from cadavers with prion diseases had prion seeding activity similar to cerebrospinal fluid (CSF), indicating the potential of skin biopsies as a diagnostic tool for these diseases.
- The objective of the research was to evaluate and compare the prion seeding activity between skin biopsies and CSF samples while considering the impact of multiple skin biopsy sites and various dilutions on diagnosing prion-related diseases (PRDs).
- The study included participants diagnosed with probable or genetically confirmed PRDs, with skin and CSF samples collected and analyzed using a specific assay, involving both exploratory and confirmatory cohorts across multiple settings in China.
Magnetic Resonance Imaging (MRI) is commonly used to follow the progression of neurodegenerative conditions, including multiple sclerosis (MS). MRI is limited by a lack of correlation between imaging results and clinical presentations, referred to as the clinico-radiological paradox. Animal models are commonly used to mimic the progression of human neurodegeneration and as a tool to help resolve the paradox.
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- PFDN5, a protein involved in helping other proteins fold correctly, has lower expression levels in breast cancer tissues, which is linked to poorer patient survival outcomes.
- Research showed that PFDN5 can cause breast cancer cells to stop dividing (G2/M phase arrest) while also enhancing their ability to migrate and invade other tissues.
- PFDN5 influences both the cell cycle and immune response in tumors, suggesting it could be a significant biomarker for predicting breast cancer prognosis and metastasis.
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- Androgen-deprivation therapy (ADT) is a common treatment for advanced prostate cancer but can lead to significant side effects, prompting guidelines for routine testing to monitor these effects.
- A study analyzed data from older men in Ontario, Canada, revealing that adherence to testing guidelines was notably low, with only 11.9% of patients receiving all recommended tests within the first year of ADT.
- The research highlights a need for further investigation into the factors preventing adherence to these recommendations, as most patients are not adequately monitored for potential treatment-related health issues.
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- Metabolites are crucial for monitoring health and therapeutic targets, yet their genetic influences during pregnancy remain largely unexplored.
- A genome-wide association study was conducted using genetic data from 34,394 pregnant Chinese women, identifying 53 metabolite-gene associations, with 23 being new findings.
- The research uncovered significant gene-environment interactions during pregnancy, with half of the associations showing pleiotropy and potential causal links between maternal metabolites and various human traits and diseases.
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- - Previous research shows that PFASs and heavy metals are toxic to reproductive health, but their combined effects have not been thoroughly studied before this investigation.
- - This study analyzed data from the National Health and Nutrition Examination Survey and found positive associations between certain PFASs (like PFOA, PFOS, and PFHxS) and heavy metals (lead and mercury) with increased risks of pregnancy loss and impacts on reproductive lifespan in females.
- - The findings indicate that cholesterol and delayed menopause play roles in the relationships observed, and there are key overlapping genes linked to abortion that may operate through oxidative stress mechanisms.
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- Highlights key research findings and innovations across various topics.
- Showcases contributions from leading experts and scholars in the field.
- Emphasizes the importance of interdisciplinary collaboration in advancing knowledge.
Editors' selections from the current scientific literature.
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- The binocular surgical microscope has long been the standard tool for visualization in otology, but recently the 3D exoscope has emerged as a new option for pediatric cochlear implantation.
- This study details the use of the Vitom® 3D system in a quaternary pediatric CI center, covering 68 cases with a mix of bilateral and revision implantations, highlighting a low conversion rate back to traditional microscopy.
- The authors note benefits of the exoscope, including high-definition imaging and improved surgical training, while acknowledging some limitations like focus issues and signal clarity at high magnification.
The dynamic nature of bacterial lipid membranes significantly impacts the efficacy of antimicrobial therapies. However, traditional assay methods often fall short in replicating the complexity of these membranes, necessitating innovative approaches. Herein, we successfully fabricated model bacterially supported lipid bilayers (SLBs) that closely mimic the characteristics of Gram-positive bacteria using the solvent-assisted lipid bilayer (SALB) technique.
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- Stress urinary incontinence (SUI) is a prevalent issue affecting women's quality of life after radical hysterectomy for cervical cancer, with a 27.8% incidence found in a recent study.
- The study analyzed demographic and clinical data from 97 women, identifying menopause, chronic constipation, and certain urodynamic parameters as significant factors linked to the occurrence of SUI.
- Key findings suggested that menopausal status and chronic constipation were particularly strong predictors of SUI, highlighting the need for targeted follow-up care for affected patients.
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- The study explores the causal relationship between different types of hearing impairment and their effects on dementia and cognitive function using two-sample Mendelian randomization analysis.
- Results indicate that certain types of hearing loss, like conductive and sensorineural, are linked with specific dementia risks, particularly Lewy body dementia and frontotemporal dementia, while also affecting cognitive performance.
- The analysis finds that factors like loneliness and depression, as well as changes in brain structure, mediate the relationship between hearing impairment and dementia, rather than aging or stroke.
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- - A biofilm lifestyle helps bacterial pathogens thrive by shielding them from host immunity and antimicrobial treatments, but how plants' biofilm processes work is not fully understood.
- - The RuvC protein from *Ralstonia solanacearum* promotes biofilm growth and pathogenicity in tomatoes by targeting structures that weaken the biofilm's DNA framework, aiding in bacterial spread.
- - Introducing RuvC in plants can enhance resistance to diseases like bacterial wilt and blight, while a similar protein (MOC1) in plants can also inhibit bacterial biofilm formation, suggesting strategies for improving crop resistance to vascular diseases.
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- * A recent case involved a 63-year-old woman in China who died from co-infection of H3N2 and H10N5, highlighting the evolving risk of these viruses to humans.
- * Evolutionary analysis revealed that H10N5 viruses from wild birds in China are genetically distinct from those in humans and show frequent reassortment, indicating ongoing risks of spillover and public health threats.
Heavy metal is a serious environmental pollutant with all kinds of biotoxic effects. The immunomodulatory effects of Cd stress on Lymantria dispar larvae and its underlying mechanisms were investigated. The susceptibility of Cd-treated larvae to Beauveria bassiana (Bb) was significantly increased by 27.
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- Hydrogen titanates (HTOs) are layered titanium oxides with an interlayer that holds water and protons, influencing lithium insertion during electrochemical processes.
- The study employed various techniques like X-ray diffraction and mass spectroscopy to analyze how the interlayer chemistry affects the electrochemical responses of different HTOs (HTiO·HO with n = 3, 4, and 5).
- Findings suggest that the first reduction reaction relates to the acidity of structural protons, leading to hydrogen gas production and the formation of a lithiated hydrogen titanate, impacting our understanding of electrochemical behaviors in materials with hydrogen and water.
Background: Previous studies have shown that gut microbiota dysbiosis could affect clinical prognosis through an unknown mechanism. However, the causal relationship between the gut microbiota and the functional outcome after ischemic stroke remains unclear. We aimed to investigate the causal association between the gut microbiota and the functional outcome after ischemic stroke using Mendelian randomization (MR).
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- The study investigates the clinicopathological characteristics and prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) using data from 72 cases at West China Hospital.
- Researchers employed techniques like immunohistochemistry and fluorescence in situ hybridization to assess various tumor factors including human epidermal growth factor receptor 2 (HER2) expression and FGFR2 gene alterations.
- Key findings indicate 49 cases were classic type cHCC-CCA, with an average survival of 18.9 months; tumor size, TNM stage, and serum AFP levels were identified as significant prognostic factors.