Lithium Bond-Mediated Molecular Cascade Hydrogel for Injury-Free and Repositionable Adhesive Bioelectronic Interfaces.

Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human-machine interactions. However, achieving both stable adhesion and non-damaging detachment remains a significant challenge. In this study, a lithium bond-mediated molecular cascade hydrogel (LMCH) for bioelectronic interfaces is designed, which facilitates robust adhesion at the tissue level and permits atraumatic detachment for repositioning as required.

Hesperetin-Enhanced Metformin to Alleviate Cognitive Impairment via Gut-Brain Axis in Type 2 Diabetes Rats.

Diabetes constitutes a risk factor for cognitive impairment, whereas insulin resistance serves as the shared pathogenesis underlying both diabetes and cognitive decline. The use of metformin for treating cognitive impairment remains controversial. The present study found that hesperetin, a flavanone derived from citrus peel, enhanced metformin's efficacy in reducing blood sugar levels, improving insulin sensitivity, and ameliorating cognitive impairment in diabetic rats.

Emergence of a novel reassortant H3N3 avian influenza virus with enhanced pathogenicity and transmissibility in chickens in China.

H3N3 avian influenza viruses (AIVs) are less prevalent in poultry than H3N8 viruses. However, although relatively rare, reassortant H3N3 viruses have been known to appear in both domestic poultry and wild birds. In this study, we isolated the H3N3 virus in chickens sourced from a live poultry market in China.

Observation on efficacy of autologous platelet rich fibrin combined with ultra-pulsed carbon dioxide laser in the treatment of cancellous bone exposed wounds.

This study is to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) combined with ultra-pulsed carbon dioxide laser in treating cancellous bone-exposed wounds. A total of 65 patients with cancellous bone-exposed wounds were retrospectively analyzed selected. There were 35 cases in ultra-pulsed carbon dioxide laser + PRF group (Laser group, group L), and 30 cases in routine surgical debridement + PRF group (Routine group, group R).

Immune Cell Crisis and Excess Histopathological Features During the Development and Progression of Infection in the Gastric Mucosa.

Objective: To investigate immune cell crisis and excess histopathological features during the development and progression of infection in the gastric mucosa.

Methods: One thousand two hundred and seventy-six cases of infection were examined by endoscopic biopsy and endoscopic submucosal dissection (ESD) resection. The relationship between epithelial cells and immune cells and the pathological features of immune cell dysfunction and excess tissue were observed.

Quality, bioactivity and cytotoxicity of thymol nanofiber-fortified bread: Insight into molecular interaction mechanism.

Thymol, a bioactive compound, offers significant potential in functional foods but its application is limited by poor stability, solubility and bioavailability. This study aimed to enhance thymol's stability and bioactivity by encapsulating it in pullulan-whey protein isolate-based electrospun nanofibers and evaluating its effects in bread fortification. The impact of encapsulation on thymol's recovery, functional properties, bioavailability and cytotoxicity was assessed.

ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment.

Hypoxia is an established hallmark of tumorigenesis. HIF-1α activation may be the prime driver of adaptive regulation of tumor cells reacting to hypoxic conditions of the tumor microenvironment. Here, we report a novel regulatory mechanism in charge of the fundamental stability of HIF-1α in solid tumor.

Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells.

Background Hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. Current treatments have limited efficacy and potential adverse effects, necessitating the development of new approaches. Purpose In this study, we investigated the effects of artesunate (ART) on hypertrophic scar (HS) formation and explored the underlying cellular and molecular mechanisms.

Hydrophilic Interaction Liquid Chromatography-Based Enrichment Method for Deciphering the N-Phosphorylated Proteome Landscape.

Protein N-phosphorylation, especially in mammals, was gradually studied and attracted widespread attention. However, the lack of effective enrichment methods resulted from the intrinsic lability of the P-N bond under acidic conditions, which seriously hindered biological function elucidation. In this work, hydrophilic two-dimensional nanocomposites with enhanced hydrophilicity and coordination interaction with phosphate were designed as the HILIC stationary phase, and then the HILIC-based strategy was developed for enrichment of N-phosphopeptides under neutral conditions.

Chiroptical Signature and Absolute Configuration of Tröger's Base-Based Triangular Macrocycles.

Chiral macrocycles are an attractive subject in supramolecular chemistry because of their proven relevance in appealing applications such as asymmetric catalysis, selective absorption, or chiral recognition. Taking into account the strong topological nature of these topics, the determination of the exact 3D structure of a chiral macrocycle becomes critical to developing all of its potential usages. In this paper, we have addressed the absolute configuration determination of a Tröger's base-based triangular macrocycle, , by means of vibrational and electronic chiroptical spectroscopy with the support of DFT quantum chemistry calculations.

Ultrasound-guided renal subcapsular transplantation of mesenchymal stem cells for treatment of acute kidney injury in a minipig model: safety and efficacy evaluation.

Background: Acute kidney injury (AKI) is a major global public health concern with limited treatment options. While preclinical studies have suggested the potential of mesenchymal stem cells (MSCs) to repair and protect injured kidneys in AKI, clinical trials using transarterial MSCs transplantation have yielded disappointing results. This study aimed to investigate the feasibility and safety of minimally invasive renal subcapsular transplantation of MSCs for treating AKI in a minipig model, ultimately aiming to facilitate the clinical translation of this approach.

Quantitative nanometer-scale characterization of densification in fused silica s-SNOM.

Fused silica is extensively used across various industries due to its superior properties, but densification can significantly alter its performance. Detecting these changes requires high spatial resolution, which challenges the limits of current testing methods. This study explores the use of scattering-type scanning near-field optical microscopy (s-SNOM) to analyze densification in fused silica through a combination of experimental techniques-atomic force microscopy-based infrared spectroscopy (AFM-IR) and s-SNOM-and computational methods, including first-principles calculations and the finite dipole model (FDM).

Identification and Network Construction of mRNAs, miRNAs, lncRNAs, and circRNAs in Sweetpotato ( L.) Adventitious Roots Under Salt Stress via Whole-Transcriptome RNA Sequencing.

Sweetpotato is the seventh largest crop worldwide, and soil salinization is a major environmental stress limiting its yield. Recent studies have shown that noncoding RNAs (ncRNAs) play important regulatory roles in plant responses to abiotic stress. However, ncRNAs in sweetpotato remain largely unexplored.

Development and Validation of an Assay to Quantify Plasma Circulating Tumor Human Papillomavirus DNA for 13 High-Risk Types that Cause 98% of HPV-Positive Cancers.

Purpose: Plasma circulating tumor HPV DNA (ctHPVDNA) persistence after curative-intent treatment may identify patients with HPV-positive cancers at risk for recurrence. Technical validation is required for use as an integral biomarker in a prospective clinical trial.

Methods: Development and analytical validation of a digital droplet PCR assay for detection and quantification of 13 high-risk HPV types (i.

Near-Infrared Light-Mediated Living Cells Mitochondrial Proteome Proximity Labeling.

Photocatalytic proximity labeling techniques enable significant advances in understanding the subcellular proteome. However, current methods primarily utilize visible light that suffers from low labeling efficiency and limited identification coverage due to absorption overlap with endogenous chromophores and scattering in biological samples. To address these issues, we reported the proximity labeling strategy using near-infrared excitation (PL-NIR) strategy, a proximity labeling platform that used a near-infrared-excited catalyst to activate labeling mediated by reactive oxygen species, which could avoid the disadvantages of visible light.

Association between pathological scar and hypertension: A two-sample Mendelian randomization study.

Observational studies have linked pathological scars to hypertension; however, the causality remains ambiguous. In this study, we aimed to explore this issue using Mendelian randomization (MR). We obtained genome-wide association study data for hypertrophic scar and hypertension from the IEU Open genome-wide association study project [hypertension (containing 9851,867 SNPs, observation group of 124,227, and control group of 337,653), hypertrophic scars (containing 16,380,443 SNPs with a sample mass of 207,482), and keloids (containing 24,197,210 SNPs and sample volume of 481,912)].

Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration.

Background: Diabetic retinopathy (DR), a microvascular disorder linked to diabetes, is on the rise globally. Oxidative stress and immune cell infiltration are linked to illness initiation and progression, according to recent study. This study investigated biomarkers connected to DR and oxidative stress and their connection with immune cell infiltration using bioinformatics analysis and found possible therapeutic medications.

A MEMS traveling-wave micromotor-based miniature gyrocompass.

Traditional gyrocompasses, while capable of providing autonomous directional guidance and path correction, face limitations in widespread applications due to their large size, making them unsuitable for compact devices. Microelectromechanical system (MEMS) gyrocompasses offer a promising alternative for miniaturization. However, current MEMS gyrocompasses require the integration of motor rotation modulation technology to achieve high-precision north-finding, whereas conventional motors in previous research introduce large volume and residual magnetism, thus undermining their size advantage.

[Research Progress of ALK Activation Pattern Changes and Targeted Therapy in Advanced Lung Cancer].

Lung cancer is the most common cancer in China and even in the world, and it is also the main cause of cancer death. Patients with anaplastic lymphoma kinase (ALK) gene alterations have the opportunity to receive molecularly targeted therapies. The inhibitors of anaplastic lymphoma kinase, such as ALK-tyrosine kinase inhibitors (ALK-TKIs) significantly prolong the survival of patients.

Design, synthesis and biological evaluation of Streptazolin analogs as anti-inflammatory agents.

A plant endophytic actinomycete Streptomyces sp. JS39-4 was isolated from the root of water spinach (Ipomoea aquatica Forsk.).

Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection.

Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection in patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, a common experimental model of angiotensin II-induced aortopathy in mice appears independent of high blood pressure as lesions do not occur in response to an alternative vasoconstrictor, norepinephrine, and are not prevented by co-treatment with a vasodilator, hydralazine. We investigated vasoconstrictor administration to adult mice following 1 week of disrupted TGFβ signaling in smooth muscle cells (SMCs).

Development and characterization of small translocations between the Pm13 introgression from Aegilops longissima and wheat homoeologous A, B and D chromosomes.

Background: Wild relatives have substantial impacts on the resistance of wheat to biotic and abiotic stresses. The genetic diversity of these wild varieties can be employed to widen the wheat gene pool by introducing wild allele introgression and genome structure variations. The powdery mildew resistance gene Pm13 was derived from the wheat wild relative species Aegilops longissima (SS, 2n = 2x = 14) and was transferred into wheat chromosome 3BS over 30 years.

Advancements in the study of T lymphocytes in thoracic aortic aneurysm and aortic dissection.

Thoracic aortic aneurysms and dissection (TAAD) is a critical, life-threatening cardiovascular condition characterized by immune-mediated inflammatory infiltration and structural degradation of the aorta wall, which are pivotal in its etiology. In recent years, the significance of T lymphocytes in TAAD has increasingly garnered scientific attention. TAAD is a multifaceted vascular disorder characterized by the involvement of many immune cells, with T lymphocytes playing a pivotal role, particularly in the modulation of inflammatory responses, immunological control, and tissue damage.

Eliminating electron localization by molecular array induces uniform zinc deposition enabling stable zinc anode.

Electrolyte additives are considered as a straightforward and effective approach for steadying zinc anode. Nevertheless, most reported adsorption-type additives primarily focus on modulating the transport of Zn and inhibiting side reactions, while neglecting the regulation of the surface state of zinc anode, which determines the final depositional behavior of Zn. Herein, vanillin acetate molecules incorporating strong electron-withdrawing and electron-donating groups, and conjugated benzene rings and capable of assembling into compact molecular array layers on zinc anodes are designed as functional electrolyte additives for optimizing the performance of zinc metal anode.

Base-Promoted Regioselective Annulation of Pyridinium Ylides and Bromoalkynes for the Chemodivergent Synthesis of Indolizines.

A base-promoted regioselective formal [3 + 2] annulation of pyridinium ylides with bromoalkynes is reported, producing a series of substituent-diverse indolizines in generally good yields. A mild KCO-promoted three-component formal [3 + 2] cyclization of pyridinium ylides and bromoalkynes at a 2:1 molar ratio delivered C2-acylmethylated indolizines, whereas C2-brominated indolizines were generated starting from pyridinium ylides bearing strong electron-withdrawing groups at the pyridinium unit by using 2,2,6,6-tetramethyl-1-piperidinyloxy as a dehydrogenating reagent. The current synthetic methodology offers a controllable and modular approach to access indolizines with different substitution patterns, featuring a wide substrate scope, good functional group compatibility, and complete regioselectivity without the demand of any transition-metal catalysts.