Publications by authors named "Jiang Bin Li"
Objective: To investigate the role of the lncRNA MEG3 (MEG3) in opposing the biochemical processes thought to be involved in the development of atherosclerosis (AS).
Methods: Thirty patients with AS and thirty healthy control subjects were enrolled in this study. The expression of MEG3, miR-200b-3p and ABCA1 was analyzed by RT-qPCR in the individuals and the macrophages-derived foam cells.
Article Synopsis
- This study assesses the effectiveness and safety of Ningmitai Capsules for treating urinary tract infections (UTIs) by reviewing randomized controlled trials from multiple medical databases.
- The meta-analysis included 17 studies with nearly 2,000 participants, revealing that Ningmitai Capsules combined with standard antibiotics led to better outcomes, such as higher clinical cure rates and quicker symptom relief.
- The results indicated significant improvements for treating acute pyelonephritis and diabetes-related UTIs, outperforming conventional antibiotics alone in various measurable outcomes.
The study was aimed at exploring the clinical value of a 14-zone lung ultrasound scoring (LUS) method in treating neonatal respiratory distress syndrome (NRDS) with pulmonary surfactant (PS) and determining the timing of mechanical ventilation (MV). In this study, 88 neonates with NRDS who received PS replacement therapy were selected. We applied a new 14-zone LUS method before and 12, 24, 48 and 72 h after PS treatment to explore the clinical value of assessing PS replacement therapy efficacy in NRDS.
View Article and Find Full Text PDFAtherosclerosis (As) is a chronic cardiovascular disease characterized by abnormal of lipid accumulation and cholesterol efflux. The present study aimed to investigate whether the micro-RNA (miR)-200b-3p could exacerbate As by promoting lipid accumulation and inhibiting cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) in macrophage-derived foam cells. Blood samples from 30 patients with As and 30 healthy people were collected at Quanzhou First Hospital.
View Article and Find Full Text PDFCellular senescence is an irreversible growth arrest of cells that maintain their metabolic activities. Premature senescence can be induced by different stress factors and occurs in mouse embryonic fibroblasts (MEFs) derived from Zmpste24 metalloproteinase‑deficient mice, a progeria mouse model of Hutchinson‑Gilford Progeria Syndrome. Previous studies have shown that miR‑342‑5p, an intronic microRNA (miRNA/miR) reportedly involved in ageing associated diseases, is downregulated in Zmpste24‑/‑ MEFs.
View Article and Find Full Text PDFArticle Synopsis
- Zmpste24 is a metalloproteinase that helps convert prelamin A to lamin A, and Zmpste24(-/-) mice show symptoms similar to progeria due to an alteration in lamin A.
- The study found significant changes in miRNA expression when comparing mouse embryonic fibroblasts (MEFs) from wild type and Zmpste24(-/-) mice, identifying 306 known miRNAs, with 8 down-regulated and 2 up-regulated in the progeroid mice.
- Notably, miR-365 was down-regulated in Zmpste24(-/-) MEFs and was shown to enhance cell growth and decrease senescence markers, targeting Rasd1 as
Article Synopsis
- This study evaluated the effectiveness and safety of Jinhua Qinggan Granule (JHG) in treating influenza patients suffering from wind-heat affecting the lungs (WHAFS).
- A total of 136 patients were split into three groups: a high dose JHG group, a low dose JHG group, and a placebo control group, with treatments administered three times daily for five days.
- Results indicated that the low dose JHG group had a faster fever disappearance time and higher recovery rates compared to the placebo, while safety was comparable across all groups.
Article Synopsis
- Nar1p is an essential protein in yeast that is similar to bacterial hydrogenases and is crucial for the maturation of certain iron-sulfur proteins.
- Nar1p helps regulate oxygen sensitivity in yeast and C. elegans and its deficiency leads to shorter lifespans and increased sensitivity to oxidative stress from paraquat.
- Enhancing mitochondrial superoxide dismutase levels can rescue the negative effects of Nar1 deficiency, indicating that Nar1p plays a protective role against oxidative stress and contributes to lifespan extension.
Aim: To determine the clinical value of a splenorenal shunt plus pericardial devascularization (PCVD) in portal hypertension (PHT) patients with variceal bleeding.
Methods: From January 2008 to November 2012, 290 patients with cirrhotic portal hypertension were treated surgically in our department for the prevention of gastroesophageal variceal bleeding: 207 patients received a routine PCVD procedure (PCVD group), and 83 patients received a PCVD plus a splenorenal shunt procedure (combined group). Changes in hemodynamic parameters, rebleeding, encephalopathy, portal vein thrombosis, and mortality were analyzed.