Publications by authors named "Jiang B"
Urea is a widely applied fertilizer to enhance crop yields. Ecological risks associated with the excessive application of urea fertilizer threaten the paddy fields' sustainable agriculture and biodiversity preservation. There are no practical thresholds based on proven data on microbial communities.
View Article and Find Full Text PDFA novel prognostic risk score model based on RNA editing level in lower-grade glioma.
Comput Biol Chem
December 2024
Background: Lower-grade glioma (LGG) refers to WHO grade 2 and 3 gliomas. Surgery combined with radiotherapy and chemotherapy can significantly improve the prognosis of LGG patients, but tumor progression is still unavoidable. As a form of posttranscriptional regulation, RNA editing (RE) has been reported to be involved in tumorigenesis and progression and has been intensively studied recently.
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- Adipokines are important for the thermogenesis (heat production) in beige fat cells, but the specific processes are still unclear.* ! -
- This study reveals that signaling between VEGFB and VEGFR1 enhances thermogenesis in white adipose tissue (WAT), with VEGFB increasing in fat cells and VEGFR1 in macrophages when thermogenesis is activated.* ! -
- Removing VEGFB from fat cells reduces browning in WAT, while adding VEGFB boosts thermogenesis, but this effect is negated if VEGFR1 in macrophages is knocked out; the study also shows how VEGFB influences signaling pathways to promote norepinephrine clearance in macrophages.* !
Industry-produced hydrazine (NH) is released into the environment, posing a major risk to human health and the ecosystem. Therefore, it is imperative to develop an effective and convenient method for the detection of NH. Herein, artificial light-harvesting systems (ALHSs) for NH detection were constructed by applying an aggregation-induced emission-active platinum(II) metallacycle () as the energy donor and rhodols (, , and ) as the energy acceptors.
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- Metabolic-associated fatty liver disease (MAFLD) is a chronic condition with no approved treatments, and the protein HIF-1α plays a crucial role in its development.
- Researchers previously found that a carbon monoxide (CO) donor could effectively target HIF-1α in mice with liver fat buildup.
- This study investigates how the relationship between HIF-1α and HO-1 (which produces CO) creates a negative feedback loop that regulates MAFLD, revealing that this loop can be disrupted in high-fat diet conditions, but additional CO could help manage the disease's progression.
Article Synopsis
- MOSPD1 is found to be overexpressed in breast cancer (BC) tissues compared to normal tissues, indicating a possible role in cancer progression and poor patient outcomes.
- Functional experiments demonstrated that reducing MOSPD1 levels inhibited tumor growth and improved the effectiveness of anti-PD-L1 therapy in BC cells.
- The study suggests that MOSPD1 could serve as a biomarker for negative clinical outcomes and a potential therapeutic target to enhance treatment responses in patients with breast cancer.
Aim: Lung cancer growth rate influences screening strategies and treatment decisions. This review aims to provide an overview of primary lung cancer growth rate, quantified by volume doubling time (VDT) through computed tomography (CT) measurement.
Methods: Using PRISMA-DTA guideline, PubMed, EMBASE, and Web of Science were searched until March 2024 for studies reporting CT-measured VDT of pathologically confirmed primary lung cancer before intervention.
Article Synopsis
- Scientists created a special rice wine using coffee flowers, which have helpful health benefits.
- They studied how the bacteria and fungi changed during the fermentation process and found out which ones were the most important.
- After some testing, they made a tasty coffee flower rice wine with a nice aroma and specific flavors, which can help improve how it's made in the future.
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- The study investigated the challenges of detecting central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC) who also have Hashimoto's thyroiditis (HT), aiming to find independent predictors for CLNM.
- A total of 242 PTC patients were analyzed, with data collected on demographic factors, ultrasound features, and genetic mutations like BRAF, using multivariate logistic regression to establish predictors and develop a prediction model.
- Key independent predictors identified included gender, tumor size, multifocality, tumor margins, and thyrotropin receptor antibodies, with the model showing good accuracy (77.5%) and effectiveness in predicting CLNM in this patient population.
Editorial: Stem cells and extracellular vesicles in aging-related diseases.
Front Cell Dev Biol
September 2024
Article Synopsis
- Salicylic acid (SA) is crucial for plant defense against certain pathogens, and its levels spike significantly at infection sites, yet how pathogens cope with this SA stress is still unclear.
- Research identified a specific operon (Xcc4167-Xcc4171) in the pathogen Xcc that encodes a transcription factor (HepR) and an SA efflux pump (HepABCD), both of which play roles in sensing and evicting SA during infection.
- The study concluded that HepR acts as a novel SA sensor that regulates the operon's expression, and the efflux pump is essential for Xcc's virulence in host plants like Chinese radish and cabbage.
Herein, we present a protocol for culturing patient-derived organoids (PDOs) of cervical cancer that includes workflows for tumor biopsy/resection tissue and cytobrush-sampled cells. We describe steps for PDO culture initiation, including rinsing, gentle dissociation, Lymphoprep separation, and cell assessment, as well as seeding cells from surgical and cytobrush tissue digestion. We then provide guidance on PDO maintenance and passage and techniques for producing conditioned medium.
View Article and Find Full Text PDFObjective: Accurate and prompt identification of periprosthetic joint infections (PJIs) is critical prior to re-revision arthroplasty to ensure optimal surgical outcomes. Among routinely measured blood indices, red blood cell distribution width (RDW) and platelet count (PLT) have shown strong correlations with infection presence. This study aimed to assess the utility of RDW and PLT for diagnosing PJI in patients scheduled for re-revision arthroplasty.
View Article and Find Full Text PDFObjective: To identify HBV-related genes (HRGs) implicated in osteoporosis (OP) pathogenesis and develop a diagnostic model for early OP detection in chronic HBV infection (CBI) patients.
Methods: Five public sequencing datasets were collected from the GEO database. Gene differential expression and LASSO analyses identified genes linked to OP and CBI.
Background: Somatic copy number alterations (SCNAs) are pivotal in cancer progression and patient prognosis. Dysregulated long non-coding RNAs (lncRNAs), modulated by SCNAs, significantly impact tumorigenesis, including colorectal cancer (CRC). Nonetheless, the functional significance of lncRNAs induced by SCNAs in CRC remains largely unexplored.
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- Inherently chiral medium-ring derivatives, crucial for fields like materials science and asymmetric catalysis, face challenges in enantioselective assembly, particularly using organocatalysis.
- Researchers introduce a novel method using N-heterocyclic carbenes (NHC) for a high-order (5 + 3) annulation of specific indolyl compounds with ynals, leading to the efficient creation of diverse eight-membered lactones.
- The study highlights the successful scaling up of production and potential applications of these lactones, demonstrating their practical relevance in synthetic chemistry.
Article Synopsis
- * The compound mitigates symptoms like weight loss and inflammation markers by lowering pro-inflammatory cytokines and improving intestinal structure, while also affecting gut bacteria and metabolites.
- * Notably, the use of antibiotics reduces the effectiveness of cucurbitacin IIb, but fecal transplants from treated mice can replicate its beneficial effects on colitis.
Article Synopsis
- * Intranasal LiCl in RFV was found to have a higher brain/blood lithium concentration ratio, providing better protection against memory loss and depressive behaviors without causing side effects or organ toxicity.
- * The neuroprotective effects of intranasal LiCl are linked to its ability to inhibit inflammation and the pyroptosis pathway, suggesting it could be a promising treatment for dementia and depression with minimal risks.
Article Synopsis
- This study explored how changes in hemoglobin levels affect cerebral blood flow (CBF) in patients with moyamoya disease (MMD) prior to surgery.
- It found that lower CBF was present in MMD patients compared to healthy individuals, and that hemoglobin levels were negatively correlated with CBF.
- The results indicated that CBF is a better predictor of clinical outcomes after surgery than hemoglobin levels, emphasizing the need for further research on optimal hemoglobin levels before surgical revascularization in MMD patients.
At-home storage of medications could pose a threat to public health and the environment if not handled appropriately. Excessive storage also creates health care and economic burdens. This study investigated storage practices, waste, and their determinants in China.
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- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with no effective treatments for its spread, but researchers found that metastatic cells express a protein called focal adhesion kinase (FAK), which influences choline metabolism and promotes metastasis.
- A newly designed drug, CHKI-03, effectively inhibits metastasis in various lab models by blocking CHKα, a protein linked to tumor growth, while also disrupting a feedback loop involving mTOR that fuels cancer progression.
- Combining CHKI-03 with rapamycin, an mTOR inhibitor, shows strong potential in resisting tumor growth and metastasis in models of PDAC, indicating a promising new approach for treating
Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal tissues and alveolar tissue can be classified into concussion, subluxation, extrusive luxation, intrusive luxation, lateral luxation, and avulsion. In these TDIs, management of injured soft tissue, mainly periodontal ligament, and dental pulp, is crucial in maintaining the function and longevity of the injured teeth.
View Article and Find Full Text PDFCo-based bimetallic zeolite imidazolate frameworks (ZIFs) have been shown as promising electrocatalysts for the oxygen evolution reaction, but their electronic structure's influence on the catalytic performance for overall water splitting still needs further investigation. In this study, CoV-ZIF, structured as two-dimensional (2D) nanosheet arrays, are grown on nickel foam using one-step co-precipitation strategy. Owing to the synergistic effects of vanadium (V) and cobalt (Co) reasonably regulating the electronic structure, the synthesized bimetallic ZIFs demonstrate superior catalytic performance, which required the overpotentials of only 227 and 68 mV to achieve a current density of 10 mA cm in 1 M KOH for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), respectively.
View Article and Find Full Text PDFTaking Liangshui River, the reclaimed water-receiving river in Beijing, as the research area, the types, detection frequencies, and concentrations of 16 antibiotics in water and sediment were analyzed, and their temporal-spatial variation and occurrence characteristics were discussed. The results showed that nine and 13 target antibiotics were detected in the water and sediment of Liangshui River, with the antibiotic concentration ranges of ND-116.68 ng·L and ND-235.
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