Exploring barriers to dementia screening and management services by general practitioners in China: a qualitative study using the COM-B model.

Background: Dementia has become a global public health problem, and general practitioners (GPs) play a key role in diagnosing and managing dementia. However, in Chinese primary care settings, dementia is underdiagnosed and inefficiently managed, and dementia screening and management services provided by GPs are suboptimal. The reasons underlying this gap are poorly understood.

Insight into derivative Weibull mixture model in describing simulated distributed activation energy model and distillers dried grains with solubles pyrolysis processes.

The kinetics of biomass pyrolysis is fundamental for exploring its mechanisms and optimizing its processes, which is helpful for designing its systems. The derivative Weibull mixture model was proposed for kinetic description of the simulated distribution energy model (DAEM) processes and distillers dried grains with solubles (DDGS) pyrolysis processes. The conversion rate data of these processes at different heating rates could be accurately described by the derivative Weibull mixture model.

Precise Marketing of E-Commerce Products Based on KNN Algorithm.

In order to better understand the purchase decision-making process of consumers, this paper makes an in-depth study on the precision marketing of e-commerce products on the basis of KNN algorithm. Through data mining, classic KNN algorithm, BPNN algorithm, and other methods, this paper takes the price and purchase intention of e-commerce agricultural products as an example. Based on the classic nearest neighbor algorithm, binomial function is combined with Euclidean distance formula when calculating the nearest neighbor through similarity.

A home-made sampling system coupled to hectowatt-MPT mass spectrometry in positive ion mode to confirm target ions of copper and zinc from Poyang Lake, China.

A novel home-made HSO-Nafion (HN) tube sampling system coupled to a line ion trap mass spectrometer (LTQ-MS) with a versatile ambient ionization source, hectowatt microwave plasma torch (HMPT), has manifested unique advantages for picking directly metal elements in aqueous samples and acquiring the fully characteristic MPT mass spectra of copper and zinc composite ions. Here, we report the development of a novel HN-HMPT-LTQ-MS for metal elements assay based on environmental water to analyze samples of Poyang Lake, China. Detailed multi-stage tandem mass spectra show that the general structural form of target ions is [M(NO)(HO)(OH)] for the positive ion mode.

Comparison of Intra-Abdominal Pressure Measurements in Critically Ill Patients Using Intravesical Normal Saline at 15°C, 25°C, and 35°C.

BACKGROUND The incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in intensive care units is high. Dynamic monitoring of intra-abdominal pressure (IAP) is important to treat patients with these conditions. The World Society of Abdominal Compartment Syndrome revised IAP measurement and treatment guidelines in 2013.

Characterization of Starch in Germplasms throughout Fruit Development.

Pumpkins (; Cucurbitaceae) are the rich source of nutrients and valued for their biologically active substances to be used for the treatment of several diseases. The contents, composition, and conformation of starch are the significant quality traits of . Two germplasms were targeted for analysis regarding the taste difference.

MicroRNA-138 attenuates myocardial ischemia reperfusion injury through inhibiting mitochondria-mediated apoptosis by targeting HIF1-α.

Myocardial ischemia-reperfusion (I/R) injury is considered to have a detrimental role in coronary heart disease, which is considered to be the leading cause of death worldwide. However, the molecular mechanism involved in the progression of myocardial I/R injury is still unclear. The current study aimed to investigate the expression and function of microRNA (miR)-138 in the process of myocardial I/R injury.

Diabetes in Shenzhen, China: epidemiological investigation and health care challenges.

Background: Understanding epidemiological characteristics of diabetes in a specific population will potentially benefit prevention and control of diabetes and policy-making. This study aimed to investigate the prevalence and awareness of diabetes, as well as its pharmacological, non-pharmacological and primary care management in Shenzhen, China.

Methods: A cross-sectional study was conducted.

A cross-sectional study of the prevalence, awareness, treatment and control of hypertension in Shenzhen, China.

Objectives: An understanding of the awareness, treatment and control of hypertension is helpful to guide decision-making regarding interventions to reduce the risk for diseases with hypertension as a key risk factor. This study aimed to estimate the prevalence, awareness, treatment, and control of hypertension in Shenzhen, China.

Methods: A cross-sectional study was conducted.

[Clinical application of enteral immune nutrition for chronic obstructive pulmonary disease patients].

Objective: To explore the application of enteral immune nutrition preparation for chronic obstructive pulmonary disease (COPD) patients and examine the improving effects on nutritional status, immune status and acute inflammatory reaction.

Methods: A total of 60 cases of hospitalized COPD patients on mechanical ventilation in intensive care unit (ICU) were randomly divided into immune nutrition group (containing essential fatty acids, omega-3 fatty acids, energy 1.3 kcal/ml) (study, n = 30) and standard nutrition group (self-made homogenized diet 1.

Unfolded protein response inducers tunicamycin and dithiothreitol promote myeloma cell differentiation mediated by XBP-1.

The unfolded protein response (UPR) is an essential pathway for both normal and malignant plasma cells to maintain endoplasmic reticulum (ER) homeostasis in response to the large amount of immunoglobulin (Ig) output. The inositol-requiring enzyme 1-X-box binding protein-1 (IRE1-XBP-1) arm of the UPR pathway has been shown to play crucial roles not only in relieving the ER stress by up-regulating a series of genes favoring ER-associated protein degradation and protein folding, but in mediating terminal plasmacytic differentiation and maturation. Myeloma cells comprise various subsets arrested in diverse differentiated phases, and the immaturity of myeloma cells has been taken as a marker for poor prognosis, suggesting that differentiation induction would be a promising therapeutic strategy for myeloma.

Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6.

Arsenic trioxide (As(2)O(3)) has shown remarkable efficacy for the treatment of multiple myeloma (MM). Histone deacetylases (HDAC) play an important role in the control of gene expression, and their dysregulation has been linked to myeloma. Especially, HDAC6, a unique cytoplasmic member of class II, which mainly functions as α-tubulin deacetylase and Hsp90 deacetylase, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation.

Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase.

Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds were active against HIV-1 RT. Compounds 4a2 and 4d2 showed inhibitory activities with IC(50) values of 0.

Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo.

Background: Angiogenesis plays an important role in the development of multiple myeloma (MM). The interaction between MM cells and the bone marrow microenvironment stimulates the proliferation and migration of endothelial progenitor cells (EPCs). Vascular endothelial growth factor (VEGF) contributes to the formation of new blood vessels by actively recruiting circulating EPCs.

[Mechanism study on low dose tunicamycin inducing myeloma cells differentiation via unfolded protein response].

Objective: To explore the molecular mechanism of myeloma cell differentiation induced by low dose tunicamycin.

Method: U266 and RPMI8226 cells were incubated with low dose tunicamycin for 72h. Surface CD49e expression was assayed by flow cytometer (FCM), light chain protein in the cell culture supernatant by ELISA, the unfolded protein response (UPR) related gene GRP78 and GRP94 by real time PCR, and XBP1u and XBP1s transcription and translation changes by real time PCR and Western blot.

[Influence of different spliceosomes of overexpressed XBP-1 on differentiation of myeloma cells].

The aim of this study was to explore the effect of 2 different spliceosomes of X-box binding protein 1 (XBP-1), the spliced form XBP-1s and unspliced form XBP-1u, on myeloma cell differentiation and its mechanism. The overexpression plasmids pcDNA3.1-C-XBP1u and pcDNA3.

[Suppression of multiple myeloma tumor growth in vivo by transfection of platelet factor 4 or 17-70 cDNA].

This study was purposed to investigate the effects of viral vector-mediated gene transfer of platelet factor 4 (PF4) or 17-70 cDNA on cell growth of multiple myeloma (MM) in vivo. Full length and p17-70 cDNA of PF4 were cloned into virapower system to transfect packing cell line 293 and produce lentiviral vectors. 3 multiple myeloma cell lines were transferred platelet factor 4 or 17-70 cDNA by lentiviral vectors.

Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.

Background: The canonical Wnt signaling is concurrently important for osteoblast differentiation and myeloma cell proliferation. Its activation in myeloma cells and its inhibition in osteoblasts and their progenitors have been identified in the previous studies. Osteoblast progenitors and myeloma cells from a myeloma patient share the same bone marrow (BM) microenvironment, but respond differently to DKK-1 secreted by myeloma cells.

[Establishment of a bortezomib-resistant myeloma cell line and differential proteins analysis by MALDI-OF-MS].

Objective: To establish a bortezomib-resistant myeloma cell line and to investigate its mechanism.

Methods: Bortezomib-resistant NCI-H929 cell line (NCI-H929B) was obtained by stepwise increasing extracellular concentrations of bortezomib over a period of 8 months. The biological characteristics of NCI-H929 and NCI-H929B were observed.