Pain scores reduction with the use of ultrasound-guided paracervical nerve block in patients with cervical cancer undergoing intracavitary brachytherapy: A randomized controlled trial.

Study Objective: To determine the safety and effectiveness of ultrasound-guided paracervical nerve blocks for the painless treatment of patients with cervical cancer post-implantation.

Design: Single-center randomized controlled trial.

Setting: Fourth Hospital of Hebei Medical University (July 2023 to October 2023).

Effects of butyrate on intestinal ischemia-reperfusion injury via the HMGB1-TLR4-MyD88 signaling pathway.

Background: This study combined bioinformatics and experimental verification in a mouse model of intestinal ischemia-reperfusion injury (IRI) to explore the protection mechanism exerted by butyrate against IRI.

Methods: GeneCards, Bioinformatics Analysis Tool for Molecular Mechanisms of Traditional Chinese Medicine and GSE190581 were used to explore the relationship between butyrate and IRI and aging. Protein-protein interaction networks involving butyrate and IRI were constructed via the STRING database, with hub gene analysis performed through Cytoscape.

The impact of Nrf2 knockout on the neuroprotective effects of dexmedetomidine in a mice model of cognitive impairment.

The nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway represents a crucial intrinsic protective system against oxidative stress and inflammation and plays a significant role in various neurological disorders. However, the effect of Nrf2 signalling on the regulation of cognitive impairment remains unknown. Dexmedetomidine (DEX) has neuroprotective effects and can ameliorate lipopolysaccharide (LPS)-induced cognitive dysfunction.

Catalytic degradation of benzene at room temperature over FeNO sites embedded in porous carbon.

Benzene and its aromatic derivatives are typical volatile organic compounds for indoor and outdoor air pollution, harmful to human health and the environment. It has been considered extremely difficult to break down benzene rings at ambient conditions without external energy input, due to the extraordinary stability of the aromatic structure. Here, we show one such solution that can thoroughly degrade benzene to basically water and carbon dioxide at 25 °C in air using atomically dispersed Fe in N-doped porous carbon, with almost 100% benzene conversion.

ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex.

53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here, we identified acetyltransferase ESCO2 as a regulator for DSB-induced cohesin-dependent chromatin structure dynamics, which promotes 53BP1 recruitment.

Using organo-mineral complex material to prevent the migration of soil Cd and As into crops: An agricultural practice and chemical mechanism study.

The migration and transformations of Cd and As in soil are different, so it is difficult to simultaneously control them. In this study, an organo-mineral complex (OMC) material was prepared using modified palygorskite and chicken manure, the Cd and As adsorption capacities and mechanism of the OMC were explored, and the response of the crop to the OMC was clarified. The results show that the maximum Cd and As adsorption capacities of the OMC under pH values of 6-8 are 12.

Continuous positive airway pressure for treating hypoxemia due to pulmonary vein injury: A case report.

Background: Vascular injury during thoracoscopic surgery for esophageal cancer is a rare but life-threatening complication that can lead to severe hypotension and hypoxemia. Anesthesiologists need to provide rapid and effective treatment to save patients' lives.

Case Summary: A 54-year-old male patient was scheduled to undergo a thoracoscopic-assisted radical resection of esophageal cancer through the upper abdomen and right chest.

Review on Catalytic Oxidation of VOCs at Ambient Temperature.

As an important air pollutant, volatile organic compounds (VOCs) pose a serious threat to the ecological environment and human health. To achieve energy saving, carbon reduction, and safe and efficient degradation of VOCs, ambient temperature catalytic oxidation has become a hot topic for researchers. Firstly, this review systematically summarizes recent progress on the catalytic oxidation of VOCs with different types.

Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis.

Multiple studies have indicated that long non-coding RNAs are aberrantly expressed in cancers and are pivotal in developing various tumors. No studies have investigated the expression and function of long non-coding antisense RNA PCNA-AS1 in esophageal squamous cell carcinoma (ESCC). In this study, the expression of PCNA-AS1 was identified by qRT-PCR.

Impact of Graphene Oxide on Properties and Structure of Thin-Film Composite Forward Osmosis Membranes.

Forward osmosis (FO) membranes have the advantages of low energy consumption, high water recovery rate, and low membrane pollution trend, and they have been widely studied in many fields. However, the internal concentration polarization (ICP) caused by the accumulation of solutes in the porous support layer will reduce permeation efficiency, which is currently unavoidable. In this paper, we doped Graphene oxide (GO) nanoparticles (50~150 nm) to a polyamide (PA) active layer and/or polysulfone (PSF) support layer, investigating the influence of GO on the morphology and properties of thin-film composite forward osmosis (TFC-FO) membranes.

Opioid-free anesthesia compared to opioid anesthesia for laparoscopic radical colectomy with pain threshold index monitoring: a randomized controlled study.

Background: Few studies have investigated the depth of intraoperative analgesia with non-opioid anesthesia. This study evaluated whether opioid-free anesthesia can provide an effective analgesia-antinociception balance monitored by the / pain threshold index in laparoscopic radical colectomy.

Methods: We enrolled 102 patients undergoing laparoscopic radical colectomy with general anesthesia.

Effects of long-term exposure to sevoflurane on the proliferation, migration, invasion, and cisplatin sensitivity of esophageal cancer.

Background: Esophageal cancer has a high incidence and one of the highest mortality rates worldwide. There are few studies on the effects of sevoflurane on postoperative metastasis and recurrence of esophageal cancer. This study aimed to investigate the effect of sevoflurane on the progression of esophageal cancer and the underlying mechanism of the sensitivity to cisplatin.

Opioid-free anesthesia compared to opioid anesthesia for lung cancer patients undergoing video-assisted thoracoscopic surgery: A randomized controlled study.

Background: Reducing intra-operative opioid consumption benefits patients by decreasing postoperative opioid-related adverse events. We assessed whether opioid-free anesthesia would provide effective analgesia-antinociception monitored by analgesia index in video-assisted thoracoscopic surgery.

Methods: Patients (ASA Ⅰ-Ⅱ, 18-65 years old, BMI <30 kg m-2) scheduled to undergo video-assisted thoracoscopic surgery under general anesthesia were randomly allocated into two groups to receive opioid-free anesthesia (group OFA) with dexmedetomidine, sevoflurane plus thoracic paravertebral blockade or opioid-based anesthesia (group OA) with remifentanil, sevoflurane, and thoracic paravertebral blockade.

Complete and rapid degradation of glyphosate with FeCeO catalyst for peroxymonosulfate activation at room temperature.

Glyphosate, a common broad-spectrum herbicide, is a serious environmental pollutant that causes a significant threat to humans. Hence, there is a pressing task to remove glyphosate from the environment. Here, we report an excellent FeCeO catalyst synthesized via the one-step co-precipitation method for activating peroxymonosulfate (PMS) to degrade glyphosate at 25 °C.

The prognostic value of an autophagy-related lncRNA signature in hepatocellular carcinoma.

Background: lncRNA may be involved in the occurrence, metastasis, and chemical reaction of hepatocellular carcinoma (HCC) through various pathways associated with autophagy. Therefore, it is urgent to reveal more autophagy-related lncRNAs, explore these lncRNAs' clinical significance, and find new targeted treatment strategies.

Methods: The corresponding data of HCC patients and autophagy genes were obtained from the TCGA database, and the human autophagy database respectively.

HIF‑1α protein SUMOylation is an important protective mechanism of action of hypothermia in hypoxic cardiomyocytes.

Different degrees of myocardial ischemia‑reperfusion injury during open‑heart surgery are inevitable. Therapeutic hypothermia is an important technique for reducing ischemia‑reperfusion injury; however, there are numerous potential adverse effects. Furthermore, the underlying molecular mechanisms of action of therapeutic hypothermia remain unclear.

Ginkgolide B Maintains Calcium Homeostasis in Hypoxic Hippocampal Neurons by Inhibiting Calcium Influx and Intracellular Calcium Release.

Ginkgolide B (GB), a terpene lactone and active ingredient of , shows protective effects in neuronal cells subjected to hypoxia. We investigated whether GB might protect neurons from hypoxic injury through regulation of neuronal Ca homeostasis. Primary hippocampal neurons subjected to chemical hypoxia (0.

Normal temperature catalytic degradation of toluene over Pt/TiO.

Normal temperature catalytic ozonation is an effective method for the removal of volatile organic compounds (VOCs). A series of TiO-supported noble metal catalysts were synthesized by a facile impregnation method. The as-prepared catalysts were evaluated for the catalytic oxidation of toluene.

Successful intraoperative management in patients with abdominal compartment syndrome induced by giant liposarcomas: Two case reports.

Rationale: Giant intra-abdominal liposarcomas weighing over 20 kg often increase the intra-abdominal pressure (IAP), which has severe effects on the cardiovascular and respiratory systems. Abdominal compartment syndrome is defined typically as the combination of a raised IAP of 20 mm Hg or higher and new onset of organ dysfunction or failure. The anesthetic management and perioperative management are very challenging.

Complete Degradation of Gaseous Methanol over Pt/FeO Catalysts by Normal Temperature Catalytic Ozonation.

Normal temperature catalytic ozonation (NTCO) is a promising yet challenging method for the removal of volatile organic compounds (VOCs) because of limited activity of the catalysts at ambient temperature. Here, we report a series of Pt/FeO catalysts prepared by the co-precipitation method for NTCO of gaseous methanol. All samples were found to be active and among them, the Pt/FeO-400 (calcined at 400 °C) catalyst with a Pt cluster loading of 0.

Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis.

Objectives: The aim of this study is to explore the potential neuroprotective effects of Ginkgolide B (GB), a main terpene lactone and active component in , in hypoxia-induced neuronal damage, and to further investigate its possible mechanisms.

Materials And Methods: 54 Sprague-Dawley rats were randomly divided into three groups: the untreated control group (n=18); the hypoxia group (n=18; exposed to 6000 m simulated plateau altitude for six days); and the GB group (n=18; intragastric administration of 12 mg/kg GB three days prior to rapid adaption to 6000 m and on the first two days of hypoxia). After hypoxia exposure for six days, we dissected out the brain hippocampi and performed hematoxylin and eosin staining, Nissl staining, and TUNEL staining.

The genome-wide transcriptional regulatory landscape of ecdysone in the silkworm.

Background: The silkworm, Bombyx mori, a typical representative of metamorphic insects, is of great agricultural and economic importance. The steroid hormone ecdysone (20-hydroxyecdysone, 20E) is the central regulator of insect developmental transitions, and its nuclear receptors are crucial for numerous biological processes, including reproduction, metabolism, and immunity. However, genome-wide DNA regulatory elements and the ecdysone receptor (EcR) that control these programs of gene expression are not well defined.