Vacuolar protein sorting 13 homolog C was associated with motor progression in Parkinson's disease.

Introduction: The SNP rs2414739 of Vacuolar protein sorting 13 homolog C(VPS13C) gene was identified to be linked with Parkinson's Disease (PD).

Objectives: Explore the clinical progression feature of PD patients with rs2414739 variant.

Methods: Longitudinal data were obtained from the Parkinson's Progression Marker Initiative (PPMI) cohorts.

Efficient Electrochemical Sensing of Chlorpromazine with a Composite of Multiwalled Carbon Nanotubes and a Thiacalix[4]arene-Based Metal-Organic Framework.

Chlorpromazine (CPMZ) is a representative drug for the treatment of psychiatric disorders. Excessive use of CPMZ could result in some serious health problems, and therefore, construction of a sensitive electrochemical sensor for CPMZ detection is greatly significant for human health. Herein, a feasible electrochemical method for the detection of CPMZ was provided.

A new thiacalix[4]arene-based metal-organic framework as an efficient electrochemical sensor for trace detection of Cd and Pb.

Heavy metal ions (HMIs) can lead to serious harm to human health and ecological environment. Thus, developing an efficient detection method for HMIs is extremely necessary. Herein, a new thiacalix[4]arene-based metal-organic framework (MOF) [Co(L1)(TPA)]·DMA·3CHOH·HO (Co-LTPA) (L1 = thiacalix[4]arene-based ligand and HTPA = terephthalic acid) was successfully synthesized.

Composite of a thiacalix[4]arene-copper(I) metal-organic framework and mesoporous carbon for efficient electrochemical detection of antibiotics.

Abundant use of nitrofurantoin (NFT) and metronidazole (MTZ) antibiotics has led to excessive residues in the environments and humans, resulting in serious damage to the human body and ecosystem. Therefore, effective detection of NFT and MTZ is exceedingly necessary. In this regard, metal-organic frameworks (MOFs) are promising materials as electrochemical sensors.

Thiacalix[4]arene-based metal-organic framework/reduced graphene oxide composite for electrochemical detection of chlorogenic acid.

A novel metal-organic framework [CoLCl]·2DMF (Co-L) based on thiacalix[4]arene derivative was synthesized using the solvothermal method. Then Co-L was respectively mixed with reduced graphene oxide (RGO), multi-walled carbon nanotubes (MWCNT) and mesoporous carbon (MC) to prepare corresponding composite materials. PXRD, SEM and N adsorption-desorption illustrated that composite materials have been successfully prepared.

Electrochemical Detection of Flutamide by the Composite of Complex Based on Thiacalix[4]arene Derivatives and Reduced Graphene Oxide.

In this paper, a thiacalix[4]arene complex [Zn(TIT4A)L]·4DMF·2CHOH (HL = 4,4'-oxybisbenzoic acid) (Zn-TIT4A-L) was synthesized by a solvothermal method. The composites were prepared by combining Zn-TIT4A-L with reduced graphene oxide (RGO), mesoporous carbon (MC), and multi-walled carbon nanotubes (MWCNTs), respectively. Three representative composites are Zn-TIT4A-L@RGO(1:1), Zn-TIT4A-L@MC(1:2), and Zn-TIT4A-L@MWCNT(1:2).

Efficient detection of metronidazole by a glassy carbon electrode modified with a composite of a cyclotriveratrylene-based metal-organic framework and multi-walled carbon nanotubes.

Constructing a sensitive and efficient sensor for determination of metronidazole (MNZ) is crucial in food field. Herein, a new cyclotriveratrylene-based metal-organic framework (MOF), namely, [CdL(cyclen)(HO)] (1), was constructed by self-assembly of functionalized 5,6,12,13,19,20-hexacarboxy-propoxy-cyclotriveratrylene (HL), 1,4,7,10-tetraazacyclododecane (cyclen) and Cd(II) cation under solvothermal condition. In 1, adjacent Cd(II) cations are linked by L to produce a 2D polymeric structure with carboxylate and phenolic oxygen atoms.

The therapeutic effect of ofatumumab in autoimmune encephalitis: A case series.

The management of autoimmune encephalitis (AE) with immunotherapy is non-standardized, especially in refractory AE. Ofatumumab (OFA), an anti-CD20 antibody, has not been reported in the treatment of AE. This study presented three AE cases that received the OFA treatment.

Thiacalix[4]arene-based complex with Co(II) ions as electrode modifier for simultaneous electrochemical determination of Cd(II), Pb(II), and Cu(II).

A complex [Co(TCTA)(HO)]∙10HO (Co-TCTA) based on thiacalix[4]arene derivative has been synthesized for the first time using the solvothermal method. The glassy carbon electrode (GCE) modified with Co-TCTA (Co-TCTA/GCE) could simultaneously determine Cd, Pb, and Cu at around - 0.75 V, - 0.

Higher than predicted resting energy expenditure and lower physical activity in healthy underweight Chinese adults.

Contrary to popular opinion that lean individuals "eat what they want" and exercise more, Hu et al. study a cohort of healthy underweight volunteers and reveal them to have reduced physical activity relative to normal BMI controls and lower food intake. This cohort is also shown to have higher than expected resting energy expenditure, which is associated with elevations in thyroid hormones.

Single-Component White Light Emission from a Metal-Coordinated Cyclotriveratrylene-Based Coordination Polymer.

A coordination polymer, namely, [CdL(HO)]·DMA·4HO () (DMA = ,-dimethylacetamide), was prepared by the solvothermal reaction of cyclotriveratrylene-based ligand 5,6,12,13,19,20-hexacarboxy-methoxy-cyclotriveratrylene (HL) and Cd(NO)·4HO. In , a two-dimensional structure was constructed by the connection of hexanuclear Cd-O clusters and L anions. Photoluminescence measurements indicated that displayed tunable photoluminescence through the variation of the excitation wavelength.

A 10-Year Community-Based Study of Leucine-Rich Repeat Kinase 2 G2385R Carriers' Conversion to Parkinson's Disease.

Background: The G2385R variant of leucine-rich repeat kinase 2 (LRRK2) is mainly associated with Parkinson's disease(PD) in Asian populations.

Objective: The aim of this study was to investigate the PD conversion rate and clinical characteristics of LRRK2 G2385R nonmanifesting carriers.

Methods: All participants were from the community-based longitudinal cohort of Shanghai Ruijin Hospital.

Penetrance of Parkinson disease LRRK2 G2385R-associated variant in the Chinese population.

Background And Purpose: Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) variants for Parkinson disease (PD) vary widely. G2385R is one of the most common LRRK2 variants in Asian populations, and its penetrance is currently unknown. We aimed to estimate the penetrance of G2385R in the Chinese population.

Simultaneous electrochemical detection of gallic acid and uric acid with p-tert-butylcalix[4]arene-based coordination polymer/mesoporous carbon composite.

Design and synthesis of an efficient electrocatalyst for simultaneous determination of gallic acid (GA) and uric acid (UA) is vital in the biological field. Herein, we synthesized a new p-tert-butylcalix[4]arene-based metal-organic electrocatalyst (Mn-L@MC) by combining Mn-L (HL = tetrakis[(2-biphenylcarboxyl)oxy]-p-tertbutylcalix[4]arene) and mesoporous carbon (MC) via a simple mechanical grinding method. Synergistic effect between Mn-L and MC made the Mn-L@MC composite behave high-efficiency electrocatalytic performance toward simultaneous detection of GA and UA.

A Porous Metal-Organic Framework as an Electrochemical Sensing Platform for Highly Selective Adsorption and Detection of Bisphenols.

The design of artificial receptors with a specific recognition function and enhanced selectivity is highly desirable in the electrochemical sensing field, which can be used for detection of environmental pollutants. In this facet, metal-organic frameworks (MOFs) featured adjustable porosities and specific host-guest recognition properties. Especially, the large hydrophobic cavity formed in the porous MOFs may become a potential artificial receptor.

Two new calix[4]resorcinarene-based coordination cages adjusted by metal ions for the Knoevenagel condensation reaction.

Two new calix[4]resorcinarene-based coordination cages, namely, [Zn4(TPC4R)(PDC)4]·2DMF·6H2O (1-Zn) and [In11(TPC4R)2(PDC)16(μ2-OH)2(H2O)2]·[(CH3)2NH2]·8DMF·20H2O·EtOH (2-In), have been synthesized via solvothermal reactions (TPC4R = tetra(2-(4H-pyrazol-3-yl)pyridine)calix[4]resorcinarene, H2PDC = 3,5-pyridinedicarboxylic acid, DMF = N,N'-dimethylformamide). By carefully tuning different metal ions, two structurally different cages 1-Zn and 2-In were achieved. The former shows a bowl-shaped structure, while the latter features a dumbbell-like structure.

Map2k5-Deficient Mice Manifest Phenotypes and Pathological Changes of Dopamine Deficiency in the Central Nervous System.

MAP2K5, a member of the MAPK family, is associated with central nervous system disorders. However, neural functional of Map2k5 from animal models were not well examined so far. Here, we established a Map2k5-targeted knockout mouse model to investigate the behavior phenotypes and its underlying molecular mechanism.

Macrocycle-Based Metal-Organic Frameworks with NO-Driven On/Off Switch of Conductivity.

Conductive metal-organic frameworks (MOFs) have a wide range of applications in supercapacitors, electrocatalysts, and fuel cells, while gas-driven conductive MOFs have not yet been synthesized so far. Herein, we report a gas-driven conductive MOF () constructed from calix[4]resorcinarene macrocycle and Co(II) cations, which shows the conductivity enhancement by about eight orders of magnitude through NO adsorption. The conductivities of MOF before and after the adsorption of NO were calculated to be about 1.

Self-Assembly of Polyoxometalate-Resorcin[4]arene-Based Inorganic-Organic Complexes: Metal Ion Effects on the Electrochemical Performance of Lithium Ion Batteries.

With their adjustable structures and diverse functions, polyoxometalate (POM)-resorcin[4]arene-based inorganic-organic complexes are a kind of potential multifunctional material. They have potential applications for lithium ion batteries (LIBs). However, the relationship between different coordinated metal ions and electrochemical performance has rarely been investigated.

Three Resorcin[4]arene-Based Two-Dimensional Zn(II) Supramolecular Isomers Synthesized via a Structure-Directing Strategy for Knoevenagel Condensation.

Herein, in the presence of three structure-directing agents (SDAs), a family of imidazole-functionalized resorcin[4]arene-based coordination polymers (CPs), [Zn(TIC4R)(HCOO)]·HCOO·0.5DMF·1.5HO (), [Zn(TIC4R)(CN)]·HCOO·DMF·2.

The Prevalence and Risk Factors of Cerebral Microbleeds: A Community-Based Study in China.

Introduction: Cerebral microbleeds (CMBs) are frequently found in the healthy elderly. However, data on the prevalence and risk factors of CMBs in the general population of China are lacking.

Methods: A cross-sectional study focusing on the prevalence and risk factors of CMBs was conducted in stroke-free elderly from Shanghai Wuliqiao community.