Efficacy and safety of a new disposable percutaneous positioning device invented to facilitate the precision of percutaneous core needle lung biopsies: a prospective, open and randomized controlled study.

Background: A new disposable percutaneous positioning device was developed which permits adjustment of the fixing puncture angle while performing a percutaneous core needle lung biopsy (CNLB). The aim of the study was to explore the positioning accuracy and clinical safety of the new device during CT-guided percutaneous CNLB.

Methods: A prospective, open and randomized controlled study with two parallel groups was conducted on 150 patients with pulmonary nodules between July 1, 2018 and June 30, 2019 including 101 males and 49 females who were divided (allocation ratio: 1:1) into a standard CNLB group without the percutaneous positioning device (control, n=75) and a new percutaneous positioning device group combined with CNLB (experimental, n=75).

Contrast-enhanced CT longitudinal tail sign as a marker of positive resection margins in adenoid cystic carcinoma of the central airway.

Background: Due to submucosal infiltration's biological nature along the airway, adenoid cystic carcinoma (ACC) frequently leaves positive surgical margins. This study evaluated the clinicopathologic, and computed tomography (CT) features for predicting surgical margin status in central airway ACC.

Methods: We retrospectively analyzed the files of 71 patients with ACC of the central airway proven by histopathology and surgery who had presented between January 2010 and December 2018.

Use of relative CT values to evaluate the invasiveness of pulmonary subsolid nodules in patients with emphysema.

Background: Lung cancer is a major cause of death, and adenocarcinoma is the most common histologic subtype. Precise diagnosis and treatment of invasive adenocarcinoma (IAC) can substantially improve the survival of patients. However, early-stage adenocarcinomas frequently appear as subsolid nodules (SSN) on computed tomography (CT), and the optimal cut-off CT value for differentiating the invasiveness of SSNs in emphysematous patients is unclear.

Dependence of radiomic features on pixel size affects the diagnostic performance of radiomic signature for the invasiveness of pulmonary ground-glass nodule.

Objective: To investigate the effect of reducing pixel size on the consistency of radiomic features and the diagnostic performance of the downstream radiomic signatures for the invasiveness for pulmonary ground-glass nodules (GGNs) on CTs.

Methods: We retrospectively collected the clinical data of 182 patients with GGNs on high resolution CT (HRCT). The CT images of different pixel sizes (0.

Multicenter, prospective, observational study of a novel technique for preoperative pulmonary nodule localization.

Objectives: Minimally invasive surgery provides an ideal method for pathologic diagnosis and curative intent of small pulmonary nodules (SPNs); however, the main problem with thoracoscopic resection is the difficulty in locating the nodules. The goal of this study was to determine the safety and feasibility of a new localization technique tailored for SPNs.

Methods: A computed tomography (CT)-guided technique, which has a tri-colored suture and claw with 4 fishhook-shaped hooks, was designed to localize SPN preoperatively.

Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis.

Purpose: To explore imaging biomarkers that can be used for diagnosis and prediction of pathologic stage in non-small cell lung cancer (NSCLC) using multiple machine learning algorithms based on CT image feature analysis.

Methods: Patients with stage IA to IV NSCLC were included, and the whole dataset was divided into training and testing sets and an external validation set. To tackle imbalanced datasets in NSCLC, we generated a new dataset and achieved equilibrium of class distribution by using SMOTE algorithm.

Abnormal Gray Matter Structural Networks in Idiopathic Normal Pressure Hydrocephalus.

: Idiopathic normal pressure hydrocephalus (iNPH) is known as a treatable form of dementia. Network analysis is emerging as a useful method to study neurological disorder diseases. No study has examined changes of structural brain networks of iNPH patients.

Community-based lung cancer screening with low-dose CT in China: Results of the baseline screening.

Objectives: To investigate whether low-dose computed tomography (LDCT) screening is capable of enhancing the detection rate of early-stage lung cancer in high-risk population of China with both smoking and non-smoking related factors.

Methods: From 2013-2014, eligible participants with high-risk factors of lung cancer were randomly assigned to a screening group or a control group with questionnaire inquiries. Any non-calcified nodules or masses with longest diameters of ≥4 mm identified on LDCT images were considered as positive.

High-resolution Computed Tomography Features Distinguishing Benign and Malignant Lesions Manifesting as Persistent Solitary Subsolid Nodules.

Introduction: We retrospectively investigated the high-resolution computed tomography features that distinguish benign lesions (BLs) from malignant lesions (MLs) appearing as persistent solitary subsolid nodules (SSNs).

Materials And Methods: In 2015, the data from patients treated in our department with persistent solitary SSNs 5 to 30 mm in size were analyzed retrospectively. The demographic data and HRCT findings were analyzed and compared between those with BLs and MLs.

"Living" Polymerization of Ethylene and 1-Hexene Using Novel Binuclear Pd⁻Diimine Catalysts.

We report the synthesis of two novel binuclear Pd⁻diimine catalysts and their unique behaviors in initiating "living" polymerization of ethylene and 1-hexene. These two binuclear catalysts, [(N^N)Pd(CH₂)₃C(O)O(CH₂)O(O)C(CH₂)₃Pd(N^N)](SbF₆)₂ (: = 4, : = 6) (N^N≡ArN=C(Me)⁻(Me)C=NAr, Ar≡2,6⁻(Pr)₂C₆H₃), were synthesized by simply reacting [(N^N)Pd(CH₃)(N≡CMe)]SbF₆ () with diacrylates, 1,4-butanediol diacrylate and 1,6-hexanediol diacrylate, respectively. Their unique binuclear structure with two identical Pd⁻diimine acrylate chelates covalently linked together through an ester linkage was confirmed by NMR and single crystal XRD measurements.

Tumor invasiveness defined by IASLC/ATS/ERS classification of ground-glass nodules can be predicted by quantitative CT parameters.

Background: To investigate the potential value of CT parameters to differentiate ground-glass nodules between noninvasive adenocarcinoma and invasive pulmonary adenocarcinoma (IPA) as defined by IASLC/ATS/ERS classification.

Methods: We retrospectively reviewed 211 patients with pathologically proved stage 0-IA lung adenocarcinoma which appeared as subsolid nodules, from January 2012 to January 2013 including 137 pure ground glass nodules (pGGNs) and 74 part-solid nodules (PSNs). Pathological data was classified under the 2011 IASLC/ATS/ERS classification.

Efficacy of computed tomography features in predicting stage III thymic tumors.

Accurate assessment of the invasion of intrathoracic structures by stage III thymic tumors assists their appropriate management. The present study aimed to evaluate the efficacy of computed tomography (CT) features for the prediction of stage III thymoma invasion. The pre-operative CT images of 66 patients with confirmed stage III thymic tumors were reviewed retrospectively.

CT staging and preoperative assessment of resectability for thymic epithelial tumors.

Background: The aim of this study was to determine the computed tomography (CT) features potentially helpful for accurate staging and predicting resectability of thymic epithelial tumors (TET).

Methods: One hundred and thirty-eight consecutive TET patients undergoing surgical resection from April 2010 to November 2011 were prospectively entered into a database. All patients were staged according to the Masaoka-Koga staging system.

[Correlation between minimal apparent diffusion coefficient and expression of Ki-67 in glioma].

Objective: To explore the correlation between minimal apparent diffusion coefficient (minADC) and expression of Ki-67 in glioma.

Methods: Findings from 78 patients with pathologically proven gliomas (grade II:n = 28, grade III: n = 21, grade IV: n = 29) were analyzed retrospectively. The minADC value of each tumor was determined on ADC maps.

Clinical significance of a single multi-slice CT assessment in patients with coronary chronic total occlusion lesions prior to revascularization.

Accurate assessment of coronary chronic total occlusion (CTO) lesion is essential to design an appropriate procedural strategy before revascularization. The present study aims to evaluate the significance of a single multislice computed tomography (MSCT) examination in patients with CTO lesion. We retrospectively analyzed the clinical data of 23 CTO lesions in twenty patients underwent computed tomography coronary angiography (CTCA) and SPECT.

Assessment of the feeding arteries by three-dimensional computed tomography angiography prior to multi-arterial infusion chemotherapy for lung cancer.

The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with non-small cell lung cancer underwent MDCT angiography of the thorax prior to multi-arterial infusion for lung cancer. Findings on CT angiograms, including CT scans, maximum intensity projections and three-dimensional volume-rendered images, were used to evaluate the depiction of bronchial and non-bronchial systemic arteries.

Characterization of solitary pulmonary nodules: Use of washout characteristics at contrast-enhanced computed tomography.

The purpose of this study was to determine whether computed tomographic scans and attenuation measurements on contrast material-enhanced and non-enhanced computed tomographic scans could be used to characterize solitary pulmonary nodules and, in particular, to characterize these lesions using washout characteristics on contrast-enhanced computed tomography. A total of 63 patients (38 males, 25 females; age range, 21-80 years; mean age, 58±13.2 years) with pulmonary nodules revealed on contrast-enhanced computed tomography underwent 20-min delayed enhanced scans.

[Dynamic enhanced CT evaluation of solitary pulmonary nodules].

Objective: To evaluate the value of dynamic enhanced-CT in differential diagnosis of solitary pulmonary nodules.

Methods: Sixty-three solitary pulmonary nodules were evaluated by dynamic enhanced multi-slice CT. Images were obtained before and at 20 s, 30 s, 45 s, 60 s, 75 s, 90 s, 120 s, 180 s, 300 s, 540 s, 720 s, 900 s and 1200 s after the injection of contrast media.

Acute and chronic myocardial infarction in a pig model: utility of multi-slice cardiac computed tomography in assessing myocardial viability and infarct parameters.

Objectives: The aim of this study was to determine the feasibility of multi-slice computed tomography (MSCT) biphasic imaging in assessing myocardial viability and infarct parameters in both acutely and chronically infarcted pig models.

Materials And Methods: Seven pigs underwent ligation of the distal left anterior descending artery. Imaging was performed on the day of infarction and 3 months post-infarct, with contrast infusion followed by MSCT scan acquisition at different time-points.

[Establishment of a novel chinese human lung adenocarcinoma cell line CPA-Yang3 and its real bone metastasis clone CPA-Yang3BM in immunodeficient mice].

Background And Objective: The recurrence and metastasis of lung cancer is a tough problem worldwide. The aim of this study is to establish a novel Chinese lung adenocarcinoma cell line and its real bone-seeking clone sub-line for exploring the molecular mechanism of lung cancer metastasis.

Methods: The cells came from the pleural effusion of a sixty-five years old female patient with lung adenocarcinoma and supraclavicular lymph node metastases.

Establishment of an experimental human lung adenocarcinoma cell line SPC-A-1BM with high bone metastases potency by (99m)Tc-MDP bone scintigraphy.

Background: Bone metastasis is one of the most common clinical phenomena of late stage lung cancer. A major impediment to understanding the pathogenesis of bone metastasis has been the lack of an appropriate animal and cell model. This study aims to establish human lung adenocarcinoma cell line with highly bone metastases potency with (99m)Tc-MDP bone scintigraphy.

[Values in preoperative assessment of occlusion and intra-operative guidance of 64 row spiral CT in percutaneous coronary intervention for chronic coronary occlusion].

Objective: To instigate the values of 64 row spiral CT in pre-operative assessment of the occlusion and intra-operative guidance in percutaneous coronary intervention for chronic total occlusion (CTO) in coronary heart disease.

Methods: Fifteen coronary disease patients planned to receive percutaneous coronary intervention underwent 64-row spiral CT-coronary angiography and coronary angiography (CAG). The diagnostic effects of these 2 techniques were compared.

Water-assisted atom transfer radical polymerization of N-isopropylacrylamide: nature of solvent and temperature.

We demonstrate here via the atom transfer radical polymerization (ATRP) of N-isopropylacrylamide (NIPAM) at low temperature that the negative function of water in aqueous ATRP is significantly suppressed. By the addition of a small amount of water in a water-miscible organic solvent and maintaining low polymerization temperature, the ATRP of NIPAM is relatively fast and well controlled. We observed that the rate of the polymerization in pure organic solvent at a monomer concentration of 20 wt % is slow, and relatively low conversions were obtained.

Strong influences of polymerization temperature on ethylene/1-hexene copolymerization catalyzed by (2-PhInd)(2)ZrCl(2)/methyl aluminoxane.

Ethylene/1-hexene was copolymerized by an unbridged zirconocene, (2-PhInd)(2)ZrCl(2)/MAO (methyl aluminoxane) at 0 degrees C and 50 degrees C respectively. High copolymerization activity and 1-hexene incorporation were observed at 0 degrees C, with the copolymer formed having random sequence distribution and narrow molecular weight distribution. Ethylene polymerization at 50 degrees C showed high activity, but copolymerization at 50 degrees C showed much lower activity, which decreased sharply with increasing 1-hexene concentration in the monomer feed.