Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications.

The skin plays an essential role in preventing the entry of external environmental threats and the loss of internal substances, depending on the epidermal permeability barrier. Nuclear receptors (NRs), present in various tissues and organs including full-thickness skin, have been demonstrated to exert significant effects on the epidermal lipid barrier. Formation of the lipid lamellar membrane and the normal proliferation and differentiation of keratinocytes (KCs) are crucial for the development of the epidermal permeability barrier and is regulated by specific NRs such as PPAR, LXR, VDR, RAR/RXR, AHR, PXR and FXR.

YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma.

Background: UV-induced cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. The constant alterations of the lymphatic-centered immune microenvironment are essential in transforming from photoaging to cSCC. Studying the mechanism will be beneficial for new targets exploration to the early prediction of cSCC.

Modified painless photodynamic therapy for facial multiple actinic keratosis in China: A prospective split-face control study.

Background: Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for multiple actinic keratosis (AK). However, PDT-induced pain often discontinues the therapy to reduce its efficacy, limiting its application. If modified painless PDT schedule with shorter photosensitizer dressing and higher dose illumination could achieve good efficacy in AK, it is still unknown.

A dose-dependent protective effect of n-3 PUFAs in photoaging by promoting collagen production through MAPK pathway in SKH-1 mouse model.

Background: Dietary supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) can inhibit inflammation and oxidation of photoaging, but the effect and mechanism on regulation of dermis collagen remains poorly elucidated. The destruction of dermal collagen plays a crucial role in the process of long-term ultraviolet radiation (UVR) induced-photoaging, especially leading to deterioration of skin appearance and function.

Methods: In this study, we explored the protective effect of n-3 PUFAs on the regulation of collagen through the MAPK pathway using the SKH-1 photoaging mouse model.

Comparison of red light and blue light therapies for mild-to-moderate acne vulgaris: A randomized controlled clinical study.

Background: Red and blue light therapies are safe and effective treatments for mild-to-moderate acne vulgaris. However, very few previous studies have directly compared the characteristics of these two methods.

Objective: To compare the efficacy and side effects of red light (RL) and blue light (BL) for acne vulgaris and to assess these two therapies in different types of lesions.