Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula.

Xin-Shao formula is a folk remedy widely used in China to prevent and cure stroke. Cerebral ischemic reperfusion (I/R) injury often takes place during the treatment of stroke. Information about the pharmacokinetic behavior of the remedy under cerebral I/R injury conditions is lacking.

[Absorption characteristics of 5 components of Xinshao extract in Caco-2 cells].

To study the absorption characteristics of Xinshao extracts in Caco-2 cells. In this paper, human colon adenocarcinoma cell line Caco-2 cell model was established, and UPLC-MS method was applied to determinate the contents of five components of Xinshao extracts(albiflorin, gallic acid, caffeic acid, scutellarin and apigenin-7-O-glucronide) in cell lysates. This model was also used to study the effect of different drug concentrations, pH, time and temperature on the absorption of five components, investigate the transport of the five components of Xinshao extracts under the conditions with or without P-glycoprotein inhibitors, and predict the absorption mechanism of these five components in Caco-2 cells.

[Microecological distribution of toxin-producing bacteria in Fug rubripes in Bohai Sea and biological characteristics of B3B].

The study showed that toxin-producing bacteria were commonly existed in each part of Fugu rubripes body. 19 strains of high poisonous bacteria were isolated from its ovary, liver and other tissues, among which, strain B3B was identified as genus Bacillus based on its physiological and biochemical characteristics and 16SrDNA sequence, and could produce tetrodotoxin through mouse test, thinner chromatography, and mass spectrography.