Overexpression of LAG-3: a potential indicator of low immune function in tuberculosis.

Background: Tuberculosis (TB) persists as a global health challenge, with its treatment hampered by the side effects of long-term combination drug therapies and the growing issue of drug resistance. Therefore, the development of novel therapeutic strategies is critical. This study focuses on the role of immune checkpoint molecules (ICs) and functions of CD8+ T cells in the search for new potential targets against TB.

ImTooth: Neural Implicit Tooth for Dental Augmented Reality.

The combination of augmented reality (AR) and medicine is an important trend in current research. The powerful display and interaction capabilities of the AR system can assist doctors to perform more complex operations. Since the tooth itself is an exposed rigid body structure, dental AR is a relatively hot research direction with application potential.

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.

We synthesized new aroyl diheterocyclic pyrrole (ARDHEP) that exhibited the hallmarks of ferroptosis. Compound strongly inhibited U-87 MG, OVCAR-3, and MCF-7 cancer cells, induced an increase of cleaved PARP, but was not toxic for normal human primary T lymphocytes at 0.1 μM.

Preparation and application of chikungunya pseudovirus containing double reporter genes.

Chikungunya virus (CHIKV), a highly infectious and rapidly spread viral pathogen, is classified as a pathogenic agent at the biosafety level 3. Operation of live authentic CHIKV needs a specific laboratory with the P3 or above containment, which greatly confines the CHIKV-associated studies. To establish an evaluation system of CHIKV that can be utilized in a BSL2 laboratory, we constructed a pseudovirus (PsV) system of CHIKV containing double reporter genes (ZsGreen1 and luciferase).

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota.

An inflammatory cytokine storm is considered an important cause of death in severely and critically ill COVID-19 patients, however, the relationship between the SARS-CoV-2 spike (S) protein and the host's inflammatory cytokine storm is not clear. Here, the qPCR results indicated that S protein induced a significantly elevated expression of multiple inflammatory factor mRNAs in peripheral blood mononuclear cells (PBMCs), whereas RS-5645 ((4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone) attenuated the expression of the most inflammatory factor mRNAs. RS-5645 also significantly reduced the cellular ratios of CD45+/IFNγ+, CD3+/IFNγ+, CD11b+/IFNγ+, and CD56+/IFNγ+ in human PBMCs.

[Finite element analysis of the effect of plate placement angle on cervical spine stability in anterior cervical fusion surgery].

Objective: Using the method of finite element analysis, to compare the biomechanical properties between the plate deviating from the long axis of the cervical spine and the standard placement of the plate in the anterior cervical fusion surgery.

Methods: A healthy female volunteer was selected and CT scan (C-T) was performed. Using Mimics 19.

Durable clinical benefit from pyrotinib combined with carboplatin in HER2-positive relapsed breast cancer previously treated with taxanes, anthracyclines, and trastuzumab.

Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer inevitably progressed after a short response to initial trastuzumab treatment, suggesting a possibility of acquired-resistance to trastuzumab. Pyrotinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor (TKI), has been reported as an effective and safe drug for the treatment of HER2-positive relapsed or metastatic breast cancer. Pyrotinib combined with capecitabine is widely used to treat HER2-positive metastatic breast cancer in patients who have been previously treated with anthracyclines, taxanes, and trastuzumab.

[Research progress on minimally invasive treatment of anterior pelvic ring fracture].

Objective: To summarize the related research results of minimally invasive treatment of anterior pelvic ring fracture, and to improve the understanding of minimally invasive treatment of anterior pelvic ring fracture.

Methods: The literature of minimally invasive treatment of anterior pelvic ring fracture at domestic and overseas in recent years was reviewed, and the reduction and fixation methods of minimally invasive treatment were summarized and analyzed.

Results: The pelvic reduction frame may be an effective auxiliary method for minimally invasive reduction of pelvis.

Protraction of mandibular molars through a severely atrophic edentulous space in a case of juvenile periodontitis.

Moving the mandibular posterior teeth into a severely atrophic edentulous space is a challenge. A carefully designed force-and-moment system that results in bodily protraction of the posterior teeth with balanced bone resorption and apposition is needed in such cases. This report describes the treatment of a 19-year-old woman with missing mandibular first molars due to juvenile periodontitis.

[Progress of research on the relationship between calcitonin gene-related peptide and RANK/RANKL/OPG system in the bone reconstruction].

Objective: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases.

Methods: The relevant research results at home and abroad in recent years were analyzed and summarized.

Results: CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction.

[Research progress of lateral wall injury of intertrochanteric fracture].

Objective: To summarize the general concept of lateral wall, the causes of lateral wall injury, and surgical strategies in order to improve the understanding of lateral wall and reduce the complications of operation.

Methods: The related literature on lateral wall was extensively reviewed, summarized, and analyzed.

Results: The superior extent of the lateral wall is vastus lateralis ridge and the inferior extent is the intersection between the lateral femoral cortex and a line drawn at a tangent to the inferior femoral neck.

Electro-Mechanical Impedance (EMI) Based Interlayer Slide Detection Using Piezoceramic Smart Aggregates-A Feasibility Study.

Interlayer slide damage is one of the main causes of landslide hazard, inflicting huge economic losses and casualties. It is urgent to accurately detect the initiation and development of the interlayer slide damage in real time. In this paper, a study on the feasibility of using the electro-mechanical impedance (EMI) technique to detect the interlayer slide damage was presented.

Amenability of coarse spaces and -algebras.

In this article we analyze the notions of amenability and paradoxical decomposition from an algebraic perspective. We consider this dichotomy for locally finite extended metric spaces and for general algebras over fields. In the context of algebras we also study the relation of amenability with proper infiniteness.

[A pilot study on the accuracy of digital model reconstructed by cone beam CT].

Purpose: To study the feasibility of digital model produced by cone beam CT.

Methods: Ten patients seeking orthodontic treatment with congested lower incisors were enrolled in this study. Plaster models of the lower arch were made using routing method.

Trinuclear and mononuclear copper(II) complexes incorporating tetradentate 2,2'-[1,1'-(ethylenedioxydinitrilo)diethylidyne]diphenol ligand: Syntheses, crystal structures, spectral and thermal behaviors.

Mononuclear and trinuclear Cu(II) complexes with chemical formula [CuL].CH3OH (1) and [{(Cu(mu-L))2(OAc)2}Cu] (2), where H2L = 2,2'-[1,1'-(ethylenedioxydinitrilo)diethylidyne]diphenol, have been synthesized and characterized by elemental analyses, 1H NMR, IR and UV-vis spectra et al. Crystallographic data of complex 1 reveal the formation of an asymmetric mononuclear structure and a slight distortion toward tetrahedral geometry from the square planar structure, in which the introduction of the non-coordinated methanol molecule lead to the assembly of the 1D chains by hydrogen bonding, Cu.

Bis{(E)-2-[1-(eth-oxy-imino)-eth-yl]-1-naphtho-lato-κN,O}copper(II).

In the title complex, [Cu(C(14)H(14)NO(2))(2)], the discrete complex mol-ecules have crystallographic inversion symmetry. The slightly distorted square-planar coordination sphere of the Cu(II) atom comprises two phenolate O atoms and two oxime N atoms from two bidentate-chelate 2-[1-(eth-oxy-imino)-eth-yl]-1-naphtho-late O-ethyl oxime (L(-)) ligands [Cu-O = 1.8919 (17) Å and Cu-N = 1.

4-Bromo-2-({4-[(hy-droxy-imino)-meth-yl]phen-yl}imino-meth-yl)phenol.

In the title compound, C(14)H(11)BrN(2)O(2), the mean planes of the two benzene rings are almost parallel to each other, making a dihedral angle of 4.09 (1)°. An intra-molecular O-H⋯N hydrogen bond occurs.

Bis{(E)-2-[(2-chloro-3-pyrid-yl)imino-meth-yl]-6-meth-oxy-phenolato-κN,O}copper(II).

In the title mononuclear copper(II) complex, [Cu(C(13)H(10)ClN(2)O(2))(2)], the Cu(II) ion, lying on an inversion center, is four-coordinated in a trans-CuN(2)O(2) square-planar geometry by two phenolate O and two imino N atoms from two symmetry-related N,O-bidentate Schiff base ligands. The shortest Cu⋯Cu distance is 7.5743 (9) Å.

5,5'-Dimeth-oxy-2,2'-[(pentane-1,5-diyl-dioxy)bis-(nitrilo-methyl-idyne)]diphenol.

The mol-ecule of the title compound, C(21)H(26)N(2)O(6), which lies across a crystallographic inversion centre, crystallizes with two unique half-molecules in the symmetric unit and adopts a linear configuration and the imino group is coplanar with the aromatic ring, making a dihedral angle of 3.26 (3)°. Strong intra-molecular O-H⋯N and weak inter-molecular O-H⋯O and C-H⋯O hydrogen bonds and weak inter-molecular π-π stacking inter-actions [centroid-centroid distance = 4.

2,2'-[1,1'-(Decane-1,10-diyldioxy-dinitrilo)diethyl-idyne]diphenol.

The salen-type bis-oxime title compound, C(26)H(36)N(2)O(4), lies about a crystallographic inversion centre. Classical intra-molecular O-H⋯N hydrogen bonds generate two S(6) ring motifs. In the crystal structure, pairs of weak inter-molecular C-H⋯O hydrogen bonds link adjacent mol-ecules into an infinite one-dimensional supra-molecular structure.

2,2'-Dichloro-1,1'-[(pentane-1,5-diyldi-oxy)bis-(nitrilo-methyl-idyne)]dibenzene.

The mol-ecule of the title compound, C(19)H(20)Cl(2)N(2)O(2), which lies across a crystallographic inversion centre, adopts a linear configuration. The dihedral angle between the two halves of the mol-ecule is 5.14 (2)°.