Maternal Exposure to Environmentally Relevant Concentrations of Tris(2,4-di--butylphenyl) Phosphate-Induced Developmental Toxicity in Zebrafish Offspring via Disrupting foxO1/ Signaling.

Abnormal development and mortality in early life stages pose significant threats to the growth and continuation of fish populations. Tris(2,4-di--butylphenyl) phosphate (TDtBPP) is a novel organophosphate ester contaminant detected in natural waters. However, the potential effects of maternal exposure to TDtBPP on the early development of offspring embryos in fish remain unknown.

Effects of multiple novel bisphenol S analogs on adipogenesis in 3T3-L1 cells.

The increasing usage of bisphenol S (BPS) analogs as novel alternatives to bisphenol A (BPA) or BPS results in widespread exposure risks. In contrast to BPS, BPS analog-induced perturbations in lipid metabolism are largely unknown. Our study aimed to investigate the interactions of nine novel BPS analogs with peroxisome proliferator-activated receptor γ (PPARγ) and their impacts on 3T3-L1 adipogenesis.

N-cadherin-triggered myosin II inactivation provides tumor cells with a mechanical cell competition advantage and chemotherapy resistance.

The concept that mechanical cell competition may contribute to tumor cell expansion has been widely discussed. However, whether this process could occur during natural tumor progression, as well as its underlying mechanisms and clinical implications, remains largely unknown. In this study, we observed that self-seeded tumor cell lines of human oral cancer, SCC9- and SCC25-seeded cells, exhibited a mechanical competitive advantage, outcompeted neighboring cells, and became "winner" cells.

Unveiling in situ methylmercury production and degradation in aquaculture sediments: Transformation rates, functional genes and microbial methylators.

Methylmercury (MeHg) is recognized as a deleterious neurotoxin with the traits of biomagnification through the food chain and accumulation in edible aquatic products. However, the in situ production of MeHg in aquaculture environments has not been well understood. Herein, the sediments were collected from aquaculture ponds with different rearing operations.

Atmospheric black carbon (BC) in Hangzhou, China: Temporal variation, source apportionment, and case study of the 19th Asian Games.

Black carbon (BC) is a refractory form of carbonaceous aerosol generated from fossil fuel and biomass incomplete combustion, which has adverse influence on global warming, air pollution, and human health. However, the relative importance of different sources and meteorology on atmospheric BC evolution was not well understood yet, especially during special periods when series of rigorous emission reduction measures were employed. Here, over one-year observation of BC concentration was conducted in urban of Hangzhou, China from Dec.

Suspect and Nontarget Analysis of Per- and Polyfluoroalkyl Substances in Groundwater Underlying Different Land-Use Areas.

Groundwater can be contaminated by PFAS emissions, yet research on the presence and associated risks of PFAS in groundwater underlying different land-use areas remains limited. Herein, high-resolution mass spectrometry-based suspect and nontarget analyses were performed to determine PFAS occurrence in groundwater samples obtained from a rural area, a planting region, and the vicinities of a pharmaceutical park, an airport, and an industrial park in Datong City, China. A total of 31 PFAS (16 emerging and 15 legacy PFAS) were identified, and the ΣPFAS concentrations ranged from 0.

Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury.

Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported that PFOA upregulates lipid metabolism and is associated with liver injury in humans. However, when the fatty acid degradation pathway is activated, lipid accumulation still occurs, suggesting the presence of unknown pathways and mechanisms that remain to be elucidated.

Heating-Induced Redox Property Dynamics of Peat Soil Dissolved Organic Matter in a Simulated Peat Fire: Electron Exchange Capacity and Molecular Characteristics.

Peatlands store one-third of the world's soil organic carbon. Globally increased fires altered peat soil organic matter chemistry, yet the redox property and molecular dynamics of peat-dissolved organic matter (PDOM) during fires remain poorly characterized, limiting our understanding of postfire biogeochemical processes. Clarifying these dynamic changes is essential for effective peatland fire management.

Spatiotemporal Mapping of the Evolution of Silver Nanoparticles in Living Cells.

Bioaccumulated silver nanoparticles (AgNPs) can undergo transformation and release toxic Ag, which can be further reduced and form secondary AgNPs (AgNPs). However, the intricate interconversions among AgNPs, Ag, and AgNPs remain speculative. Herein, we developed a bioimaging method by coupling the aggregation-induced emission method with the label-free confocal scattering and hyperspectral imaging techniques to quantitatively visualize the biodistribution and biotransformation of AgNPs, AgNPs, and Ag in living cells.

Atmospheric Hg(0) dry deposition over environmental surfaces: Insights from mercury isotope fractionation.

Atmospheric Hg(0) dry deposition is a vital process that significantly affects the global distribution and cycling of Hg. However, significant knowledge gaps and challenges remain in understanding atmospheric Hg(0) deposition and its subsequent post-deposition processes. Hg isotope fractionation has emerged as the most powerful tool for evaluating the impact of atmospheric Hg(0) deposition and unraveling key processes associated with it.

Biotransformation of Tetrabromobisphenol A and Its Analogs by Selected Gut Bacteria Strains: Implications for Human Health.

Knowledge of the biotransformation of tetrabromobisphenol A (TBBPA) and its related contaminants by human gut microbiota (GM) remains unexplored. Here, TBBPA and its four analogs were incubated with mixed GM strains, and nine rhamnosylated or debrominated transformation products (TPs) were discovered. Remarkably, rhamnosylation was identified as a common and unique microbial transformation pathway for these contaminants, and six of the seven rhamnosylated TPs were reported for the first time.

Fire-Induced Multiple Changes in Electron Transfer Properties of Peat Soil Organic Matter: The Role of Functional Groups, Graphitic Carbon, and Iron.

Peatland fires induced changes in electron transfer properties and relevant electroactive structures of peat soil organic matter (PSOM) remain ambiguous, impeding comprehension of postfire biogeochemical processes. Here, we revealed temperature-dependent electron exchange capacity (EEC) of PSOM dynamics through simulated peat soil burning (150-500 °C), which extremely changed postfire microbial Fe-nanoparticles reduction and methanogenesis. EEC diminished significantly (60-75% loss) due to phenolic-quinone moieties depletion with increasing temperature, regardless of oxygen availability.

Nitrate-dependent antimony oxidase in an uncultured Symbiobacteriaceae member.

Autotrophic antimony (Sb) oxidation coupled to nitrate reduction plays an important role in the transformation and detoxification of Sb. However, the specific oxidase involved in this process has yet to be identified. Herein, we enriched the microbiota capable of nitrate-dependent Sb(III) oxidation and identified a new Sb(III) oxidase in an uncultured member of Symbiobacteriaceae.

Impact of Sinus CT Severity Score on the Outcomes of Endoscopic Sinus Surgery in Eosinophilic CRSwNP.

Background: Eosinophilic chronic rhinosinusitis with nasal polyps (eos-CRSwNP), especially those with diffuse disease as indicated by CT scans, has high recurrence rate and low control rate after endoscopic sinus surgery (ESS). Most of them are difficult to treat.

Objective: This study sought to identify if eos-CRSwNP patients were to undergo surgery earlier, while the disease is still limited on CT, they might achieve better postoperative outcomes.

Recent advances in environmental antibiotic resistance genes detection and research focus: From genes to ecosystems.

Antibiotic resistance genes (ARGs) persistence and potential harm have become more widely recognized in the environment due to its fast-paced research. However, the bibliometric review on the detection, research hotspot, and development trend of environmental ARGs has not been widely conducted. It is essential to provide a comprehensive overview of the last 30 years of research on environmental ARGs to clarify the changes in the research landscape and ascertain future prospects.

Field and Laboratory Evidence That Chlorpyrifos Exposure Reduced the Population Density of a Freshwater Snail by Increasing Juvenile Mortality.

Pesticides have been frequently detected in global freshwater ecosystems, but attempts to document changes in population dynamics of organisms upon exposure to pesticides, establish a causal relationship between exposure and population effects, and identify the key toxic events within individuals under natural field conditions remain rare. Here, we used a field survey, a reciprocal cross-transplant experiment, and a laboratory toxicity experiment to build a compelling case that exposure to the insecticide chlorpyrifos was responsible for differences in snail () densities in eastern (ELL) and western basins of Liangzi Lake in China. Our field survey and reciprocal cross-transplant experiment revealed significant differences in snail densities, juvenile percentage, survival, and relative telomere length (RTL) in the two basins.

H3K9 lactylation in malignant cells facilitates CD8 T cell dysfunction and poor immunotherapy response.

Histone lysine lactylation (Kla) is a post-translational modification, and its role in tumor immune escape remains unclear. Here, we find that increased histone lactylation is associated with poor response to immunotherapy in head and neck squamous cell carcinoma (HNSCC). H3K9la is identified as a specific modification site in HNSCC.

Widespread mercurous [Hg(I)] species in mercury droplet impacted environments: Evidence from an abandoned Hg smelting plant in Xunyang, China.

Mercury (Hg) emissions from Hg smelting (roasting HgS ores) and artisanal small-scale gold mining predominantly include elemental Hg, in either liquid [Hg(0)] or gaseous [Hg(0)] form. The oxidation of Hg(0) into Hg(I) is the first step during Hg(0) oxidation, which enables Hg to enter the food web. However, this oxidation process remains poorly understood, particularly in Hg(0)/Hg(0)-impacted environments.

Competitive Binding Kinetics of Methylmercury-Cysteine with Dissolved Organic Matter: Critical Impacts of Thiols on Adsorption and Uptake of Methylmercury by Algae.

Complexes with low-molecular-weight thiols are crucial species of methylmercury (MeHg) excreted by anaerobic Hg-methylating microbes, notably, MeHg-cysteine (MeHg-Cys). As MeHg-Cys diffuses into surface water, it would undergo a ligand exchange process with dissolved organic matter (DOM) under nonsulfidic conditions, inevitably altering MeHg speciation and bioavailability to phytoplankton. In this study, we investigated the competitive binding kinetics between MeHg-Cys and Suwannee River natural organic matter, and their influence on the adsorption and uptake of MeHg by the cyanobacterium, sp.

Phytoavailability, translocation, and accompanying isotopic fractionation of cadmium in soil and rice plants in paddy fields.

Rice consumption is a major pathway for human cadmium (Cd) exposure. Understanding Cd behavior in the soil-rice system, especially under field conditions, is pivotal for controlling Cd accumulation. This study analyzed Cd concentrations and isotope compositions (δCd) in rice plants and surface soil sampled at different times, along with urinary Cd of residents from typical Cd-contaminated paddy fields in Youxian, Hunan, China.

Ego4D: Around the World in 3,000 Hours of Egocentric Video.

We introduce Ego4D, a massive-scale egocentric video dataset and benchmark suite. It offers 3,670 hours of daily-life activity video spanning hundreds of scenarios (household, outdoor, workplace, leisure, etc.) captured by 931 unique camera wearers from 74 worldwide locations and 9 different countries.