Deep, high-temperature carbonate reservoirs, represented by the Chuanzhong-Gaomo Block and the Penglai Gas Field, have become important supports for increased storage and production in Sichuan Basin. However, acidization in high-temperature to ultrahigh-temperature reservoirs faces several technical challenges, such as fast acid-rock reaction rates, limited acid corrosion distances, and high risks of tubular corrosion. In this study, a novel high-temperature-resistant microencapsulated gelling agent GLE-3 was prepared using -isopropylacrylamide (NIPAM) as the wall material, acrylamide (AM), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), and -vinylcaprolactam (NVCL) as the core materials, and ,'-methylenebis(acrylamide) (MBA) as the cross-linking agent through inverse emulsion polymerization.
View Article and Find Full Text PDFDue to the intervention of human activities, the background values of riverbed sediment exhibit spatiotemporal variability, which can affect the accuracy of risk assessment results. Using risk assessment that do not rely on background values is an executable alternative to avoid such problems. In this study, a relative pollution level assessment (RPLA) method which was based on the statistical results of relevant literatures was proposed.
View Article and Find Full Text PDFThe nitritation step is the fundament for the biological nitrogen removal regardless of the traditional nitrification and denitrification process, the nitrite shunt process or the anammox process. Thus, exploring the effective nitritation performance is an important aspect of biological nitrogen removal. This study explored the upper limit of nitritation rate by increasing hydraulic residence time with the well-mixed and continuous granular sludge-type reactor characterized with low complexity and easy operation.
View Article and Find Full Text PDFTarget identification is an important step in drug discovery, and computer-aided drug target identification methods are attracting more attention compared with traditional drug target identification methods, which are time-consuming and costly. Computer-aided drug target identification methods can greatly reduce the searching scope of experimental targets and associated costs by identifying the diseases-related targets and their binding sites and evaluating the druggability of the predicted active sites for clinical trials. In this review, we introduce the principles of computer-based active site identification methods, including the identification of binding sites and assessment of druggability.
View Article and Find Full Text PDFNontarget analysis enables high-efficiency screening and identification of halogenated organic pollutants (HOPs) in complex matrices irrespective of lacking authentic standards, particularly for novel and emerging species, thereby realizing comprehensive component characterization of HOPs. Notwithstanding, nontarget analysis and comprehensive characterization of HOPs remain on the way to improvement. In this study, we implemented nontarget analysis of HOPs in fly ash, egg and sediment using gas chromatography quadrupole-orbitrap high-resolution mass spectrometry with the aid of chromatogram segmentation and Cl/Br-specific screening algorithms, and further performed comprehensive characterization of components and distribution of HOPs.
View Article and Find Full Text PDFSimultaneous sampling and observation were conducted at 14 stations in typical intertidal zones of the Guangdong-Hong Kong-Macao greater bay area. The spatial distribution characteristics of Cd morphology in surface water, pore water, suspended matters, and sediments at each sampling site were analyzed, and the influencing factors of Cd morphology changes in each medium were discussed using statistical analyses based on environmental factors. The results showed that the total contents of Cd in surface water, pore water, suspended matters, and sediments in each intertidal zone ranged from 0.
View Article and Find Full Text PDFAt the initial stage of drug discovery, identifying novel targets with maximal efficacy and minimal side effects can improve the success rate and portfolio value of drug discovery projects while simultaneously reducing cycle time and cost. However, harnessing the full potential of big data to narrow the range of plausible targets through existing computational methods remains a key issue in this field. This paper reviews two categories of in silico methods-comparative genomics and network-based methods-for finding potential therapeutic targets among cellular functions based on understanding their related biological processes.
View Article and Find Full Text PDFThis study for the first time investigated the advanced treatment of bio-treated landfill leachate effluent using a novel reactive electrochemical membrane (REM) technology at the laboratory and pilot scales. At the laboratory scale, RuO-Ir-REM, TiO-REM, and β-PbO-REM featured similar properties in pore size and water flux. Although RuO-Ir-REM holds more reactive sites than the other two REMs, β-PbO-REM and TiO-REM featured higher oxidation ability than RuO-Ir-REM, causing their high yield of hydroxyl radical.
View Article and Find Full Text PDFWith the increase of development and utilization of coastal tidal flats, the desertification of intertidal zone is becoming more and more serious, which will inevitably lead to changes in the distribution and migration of heavy metals. This study reported the multiphase distribution and solid-liquid partitioning of Cr, Ni, Cu, Zn, Pb and Cd in typical sandy intertidal zones and predicted the migration of heavy metals with stepwise multiple linear regression. The distribution of heavy metals in surface water was comparable with that in pore water, while the content of heavy metals in suspended solids was obviously greater than that in sediments.
View Article and Find Full Text PDFThe spatial and temporal distribution of polycyclic aromatic hydrocarbons (PAHs) was investigated in sediments of Maba River, a major tributary of Beijiang River (South China). A total of 13 samples from Maba River and its tributary, Meihua River, were analyzed for 16 PAHs. The total concentration of 16 PAHs (ΣPAH) in high and low water period ranged between 47.
View Article and Find Full Text PDFUnderstanding the integrated effect of external factors (e.g., human activities) and internal factors (e.
View Article and Find Full Text PDFTo date, there is a lack of a comprehensive research on heavy metals detection and ecological risk assessment in river water, sediments, pore water (PW) and suspended solids (SS). Here, the concentrations of heavy metals, including Cu, Zn, Mn, Cd, Pb and As, and their distribution between the four phases was studied. Samples for analysis were taken from twelve sites of the Hengshi River, Guangdong Province, China, during the rainy and dry seasons.
View Article and Find Full Text PDFAcid mine drainages (AMD) contain high concentrations of heavy metals, and their discharges into streams and rivers constitute serious environmental problems. This article examines the effects of AMD on soil, plant and human health at Dabaoshan mine in Guangdong Province, China. Although the large scale mining was stopped in 2011, the heavy metal pollution in soil continues to endanger crops and human health in that region.
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