Porous chitosan microspheres containing zinc ion for enhanced thrombosis and hemostasis.

Quick hemostats for non-lethal massive traumatic bleeding in battlefield and civilian accidents are important for reducing mortality and medical costs. Chitosan (CS) has been widely used as a clinic hemostat. To enhance its hemostatic efficiency, Zn in the form of zinc alginate (ZnAlg) was introduced to CS to make porous CS@ZnAlg microspheres with ZnAlg component on the surface.

Fabrication of porous chitosan membranes composed of nanofibers by low temperature thermally induced phase separation, and their adsorption behavior for Cu.

Low temperature thermally induced phase separation (LT-TIPS) of chitosan solution was developed to fabricate porous chitosan membranes (p-CSMs), which were composed of short nanofibers with diameter of 40-60nm. Compared to the conventional acetic acid/water solvent, a mixed solvent of acetic acid/ethanol/water was used to prepare chitosan solution. The effect of solvent composition, quenching temperature and time, and coagulant on the p-CSM morphology were systematically explored.