Odor induced functional connectivity alteration of POC-anterior frontal cortex-medial temporal cortex in patients with mild cognitive impairment.

Background: Mild cognitive impairment (MCI) is associated with an increased risk of dementia in older adults. Olfactory impairment may indicate prodromal dementia, yet its underlying mechanisms are not fully understood. This study aimed to investigate the alterations in functional connectivity (FC) of odor-induced olfactory neural circuits in MCI patients.

Gender differences in clinical correlates of glucose disturbance in patients with first-episode and drug-naïve major depressive disorder.

Gender differences in glucose metabolism disorders in patients with major depressive disorder (MDD) have been rarely studied. In this study we investigated gender differences in the prevalence of glucose metabolism disorders and associated factors in first-episode and drug naïve (FEDN) MDD patients in a Chinese Han population. In this cross-sectional study, a total of 1718 FEDN MDD outpatients were recruited, and demographic and clinical data were collected.

CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival.

Radiomics prediction of MGMT promoter methylation in adult diffuse gliomas: a combination of structural MRI, DCE, and DTI.

Purpose: To assess the predictive value of radiomics features extracted from structural MRI, dynamic contrast enhanced (DCE), and diffusion tensor imaging (DTI) in detecting O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in patients with diffuse gliomas.

Methods: Retrospective MRI data of 110 patients were enrolled in this study. The training dataset included 88 patients (mean age 52.

Effect of different balloon pressure band compression regimens on thrombolysis and lower limb venous blood flow velocity in patients undergoing anterograde thrombolysis via the superficial dorsalis pedis vein.

Objective: To evaluate the comparative effectiveness of two distinct balloon pressure band compression regimens on the treatment outcomes for deep vein thrombosis (DVT) and venous blood flow velocity in the lower limbs of patients undergoing anterograde thrombolysis through the superficial dorsalis pedis vein.

Methods: A total of 42 patients diagnosed with DVT were enrolled in the randomized controlled trial. Patients in the control group received balloon pressure band compression positioned 15 cm above the bony landmark of the medial malleolus of the affected limb, with continuous inflation and deflation.

Application of aqueous two-phase extraction for separation and purification of various adeno-associated viruses.

Objective: Adeno-associated viruses (AAVs) are widely used as gene therapy vectors due to their safety, stability, and long-term expression characteristics. The objective of this work is to develop an aqueous two-phase system (ATPS) as a universal platform for the separation and purification of AAVs.

Results: This study utilized polyethylene glycol (PEG)/salt ATPSs to separate and purify various AAV serotypes, including AAV5, AAV8, and AAV9, which focusing on serotype-specific performance and partial empty capsid removal.

Ultrasound radiomics in the assessment of breast cancer molecular subtypes: A systematic review and meta-analysis.

Aim: Accurate prediction of preoperative molecular subtypes of breast cancer is crucial for treatment planning and prognosis evaluation of patients. This systematic review aims to investigate the capacity of ultrasound radiomics in accurately identifying the molecular subtypes of breast cancer.

Material And Methods: We conducted a thorough search of  PubMed, Embase, and Cochrane databases to identify relevant research up until May 2024.

Radiomics for predicting grades, isocitrate dehydrogenase mutation, and oxygen 6-methylguanine-DNA methyltransferase promoter methylation of adult diffuse gliomas: combination of structural MRI, apparent diffusion coefficient, and susceptibility-weighted imaging.

Background: There has been no research investigating susceptibility-weighted imaging (SWI) radiomics features in evaluating molecular makers in gliomas. The aim of this study was to assess the predictive value of radiomics features extracted from structural magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC), and SWI in determining World Health Organization (WHO) Grade, isocitrate dehydrogenase () mutation, and oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in patients with diffuse gliomas.

Methods: Retrospective MRI data of 539 patients from University of California San Francisco and Nanjing Drum Tower Hospital between January 2010 and December 2022 were analyzed in this study.

Review of tracer kinetic models in evaluation of gliomas using dynamic contrast-enhanced imaging.

Glioma is the most common type of primary malignant tumor of the central nervous system (CNS), and is characterized by high malignancy, high recurrence rate and poor survival. Conventional imaging techniques only provide information regarding the anatomical location, morphological characteristics, and enhancement patterns. In contrast, advanced imaging techniques such as dynamic contrast-enhanced (DCE) MRI or DCE CT can reflect tissue microcirculation, including tumor vascular hyperplasia and vessel permeability.

Quantitative and Qualitative Parameters of DCE-MRI Predict CDKN2A/B Homozygous Deletion in Gliomas.

Rationale And Objectives: Homozygous deletion (HD) of CDKN2A/B holds important prognostic value in gliomas. This study aimed to explore the predictive potential of conventional MRI characteristics combined with dynamic contrast-enhanced MRI parameters in predicting CDKN2A/B HD status in gliomas.

Materials And Methods: Preoperative MRI data of 105 patients (69 without CDKN2A/B HD, and 36 with CDKN2A/B homozygous deletion) with gliomas were retrospectively collected.

Factors affecting local alveolar bone thickness in unilateral maxillary canine-lateral incisor transposition.

Introduction: This study aimed to use 3-dimensional data to investigate the factors affecting local alveolar bone thickness in unilateral maxillary canine-lateral incisor transposition.

Methods: Pretreatment cone-beam computed tomography data of 34 patients with unilateral maxillary canine-lateral transposition were imported into Dolphin Imaging software (version 11.8; Dolphin Imaging and Management Solutions, Chatsworth, Calif) for 3-dimensional reconstruction.

Th9/IL-9 may participate in the pathogenesis of multiple myeloma.

Introduction: This research is aimed to evaluate the correlation between Th9-associated cytokine levels in MM patients, clinical features, and therapy.

Methods: Peripheral blood samples were taken in 52 MM patients and 20 healthy volunteers matched by sex and age. The patients with MM were separated into two groups: the untreated group (27) and the remission group (25).

Metal-Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase-Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm-Associated Infections.

Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, a series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) with ultrafine size palladium nanoparticles and broadband near infrared absorption exhibit excellent oxidase-like activity and stable photothermal effect.

Development and validation of prognostic nomogram for elderly patients with clear cell renal cell carcinoma based on the SEER database.

This study sought to establish nomogram models of overall survival (OS) in patients with elderly clear cell renal cell carcinoma (ECCRCC). The Surveillance, Epidemiology, and End Results database provided data of the ECCRCC-afflicted patients diagnosed during the period from 2010 to 2015. This data was subsequently segregated into the training and validation sets randomly in a 7:3 ratio.

Aflibercept Loaded Eye-Drop Hydrogel Mediated with Cell-Penetrating Peptide for Corneal Neovascularization Treatment.

Corneal neovascularization (CoNV) is a major cause of visual impairment worldwide. Currently, available treatment options have limited efficacy and are associated with adverse effects due to biological barriers and clearance mechanisms. To address this challenge, a novel topical delivery system is developed-Gel 2_1&Eylea-an aflibercept-loaded eye-drop hydrogel mediated with cell-penetrating peptide 1.

Morphometric evaluation of alveolar bone after orthodontic treatment of multiple impacted teeth in the unilateral maxillary anterior region.

Introduction: This study aimed to investigate the height and thickness of alveolar bone by cone-beam computed tomography imaging after orthodontic treatment in the unilateral maxillary anterior region and speculate on reasons for the difference in alveolar bone morphology.

Methods: This study selected 11 patients (3 males and 8 females; mean age, 9.42 ± 1.

Supramolecular Photothermal Cascade Nano-Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm-Associated Tooth-Extraction Wound Healing.

Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria-infected open wounds with conventional measures is problematic. Here, a photothermal cascade nano-reactor (CPNC@GOx-Fe ) is constructed through a supramolecular strategy through hydrogen bonding and coordination interactions between chitosan-modified palladium nano-cube (CPNC), glucose oxidase (GOx), and ferrous iron (Fe ). CPNC@GOx-Fe exhibits excellent photothermal effects and powers the GOx-assisted cascade reaction to generate hydroxyl radicals, enabling photothermal and chemodynamic combination therapy against bacteria and biofilms.

Thermal analysis technology to utilize waste biomass and waste heat to produce high-quality combustible gas through simulations and experiments.

To ensure the proper utilization of waste biomass (WB) and high-temperature waste heat, this study proposes a new method for obtaining gaseous fuels by pyrolyzing WB and using waste heat in the converter vaporization cooling flue (CVCF). This study is theoretically based on the simulation software Factsage 6.1 and the release patterns of the gaseous products including CO, H, CH and CO obtained from waste biomass, were studied at different temperatures and pressures.

Basic psychological need satisfaction and well-being for gig workers: a fuzzy set QCA approach in DiDi of China.

With the rapid development of the gig economy, the psychological needs of gig workers have gradually attracted attention. The purpose of the study is to explore the relationship between basic psychological need and well-being. Fuzzy-set qualitative comparative analysis (fsQCA) was used to analyze questionnaire data from a sample of 422 DiDi drivers in China.

Neighboring Carboxylic Acid Boosts Peroxidase-Like Property of Metal-Phenolic Nano-Networks in Eradicating Streptococcus mutans Biofilms.

Developing nature-inspired nanomaterials with enzymatic activity is essential in combating bacterial biofilms. Here, it is reported that incorporating the carboxylic acid in phenolic/Fe nano-networks can efficiently manipulate their peroxidase-like activity via the acidic microenvironment and neighboring effect of the carboxyl group. The optimal gallic acid/Fe (GA/Fe) nano-networks demonstrate highly enzymatic activity in catalyzing H O into oxidative radicals, damaging the cell membrane and extracellular DNA in Streptococcus mutans biofilms.

Dynamic changes and prognosis of pulmonary congestion by lung ultrasound in hemodialysis patients: a systematic review and meta-analysis.

Aims: Lung ultrasound (LUS) has been rapidly developed to evaluate pulmonary extravascular fluid. A systematic review was conducted to study the dynamic changes of LUS findings of pulmonary congestion before and after hemodialysis and examine the application of LUS for the prognosis of hemodialysis patients.

Material And Methods: This study searched online databases for articles on hemodialysis patients that used LUS to evaluate dynamic changes during hemodialysis or prognosis.

An efficient differential sensing strategy for phenolic pollutants based on a nanozyme with polyphenol oxidase activity.

To realize the efficient differential sensing of phenolic pollutants in sewage, a novel sensing strategy was successfully developed based on a nanozyme (GMP-Cu) with polyphenol oxidase activity. Phenolic pollutants can be oxidized using GMP-Cu, and the oxidation products reacts subsequently with 4-aminoantipyrine to produce a quinone-imine compound. The absorption spectra of final quinone-imine products that resulted from different phenolic pollutants showed obvious differences, which were due to the interaction difference between GMP-Cu and phenolic pollutants, as well as the different molecular structures of the quinone-imine products from different phenolic pollutants.