The effect of paeoniflorin on the rewarding effect of methamphetamine and the associated cognitive impairment in mice.

Chronic exposure to methamphetamine (METH) has been suggested to cause METH use disorder and severe cognitive impairment. Paeoniflorin (PF) is a monoterpenoid glycoside with various beneficial effects, including anti-inflammatory, antioxidant and antidepressant. The current study was designed to investigate the effect of PF (30 mg/kg, i.

Increasing Vitamin K Synthesis in by Controlling the Expression of MenD and Stabilizing MenA.

As an indispensable member of the family of lipid vitamins, vitamin K (MK-7) plays an important role in blood coagulation, cardiovascular health, and kidney health. Microbial fermentation is favored due to its high utilization rate of raw materials, simple operation, and moderate conditions. However, the biosynthesis pathway of vitamin K in microorganisms is highly complex, which hinders its industrial production in microbial cell factories.

The de novo missense mutation F224S in GABRB2, identified in epileptic encephalopathy and developmental delay, impairs GABAR function.

Genetic variants in genes encoding subunits of the γ-aminobutyric acid-A receptor (GABAR) have been found to cause neurodevelopmental disorders and epileptic encephalopathy. In a patient with epilepsy and developmental delay, a de novo heterozygous missense mutation c.671 T > C (p.

N-acetyl-L-cysteine attenuated the toxicity of ZIF-8 on EA.hy926 endothelial cells by wnt/β-catenin pathway.

As kinds of porous crystalline compounds, zeolitic imidazolate frameworks (ZIFs) have been developed quickly and attracted considerable attention for use in nano drug delivery systems, which raised concerns about cardiovascular disorders. At the present, the cytotoxic mechanism of ZIFs in cardiovascular disorders was still unclear. Our experiment explored the toxicity of ZIF-8, a typical kind of ZIFs, on human EA.

The Cystic Anechoic Zone of Uterine Cavity Newly Observed during Controlled Ovarian Hyperstimulation Affects Pregnancy Outcomes of Fresh Embryo Transfer.

During controlled ovarian hyperstimulation (COH), cystic anechoic zones in the uterine cavity are occasionally visible. This retrospective matched cohort study collected information on patients who underwent in vitro fertilization/intracytoplasmic injection (IVF/ICSI) from January 2014 to December 2020 at our center. The propensity score algorithm matched 179 cases that had uterine cystic anechoic zones, with 358 which did not have uterine cystic anechoic zones cases.

The newly non-uniform endometrial echogenicity on transvaginal ultrasound do not impact in vitro fertilization and embryo transfer success: A retrospective cohort study.

Objective: To evaluate the effect of newly non-uniform endometrial echogenicity diagnosed by transvaginal ultrasound on the outcome of pregnancy in vitro fertilization-embryo transfer (IVF-ET) during controlled ovarian hyperstimulation (COH) by retrospective cohort analysis.

Methods: A retrospective cohort study of a total of 604 patients with newly non-uniform endometrial echogenicity from January 2013 to June 2017, each woman was matched with three control subjects of similar age (±1 year), type of infertility (primary or secondary), the protocol used for COH, and the number of ET cycles in our unit. The patients in the study group and control group were matched according to the strict 1:3 matching principle.

Epitaxial Growth of Lead-Free 2D Cs Cu I Perovskites for High-Performance UV Photodetectors.

The all-inorganic lead-free Cu-based halide perovskites represented by the Cs-Cu-I system, have sparked extensive interest recently due to their impressive photophysical characteristics. However, successive works on their potential application in light emission diodes and photodetectors rely on tiny polycrystals, in which the grain boundaries and defects may lead to the performance degradation of their embodied devices. Here, 2D all-inorganic perovskite Cs Cu I single crystals are epitaxially grown on mica substrates, with a thickness down to 10 nm.

Assessment of Cardiovascular Health of Children Ages 6 to 10 Years Conceived by Assisted Reproductive Technology.

Importance: Assisted reproductive technology (ART) has been widely used for treatment of infertility and has brought millions of births worldwide. The health of offspring conceived by ART has been of much concern, and adverse cardiovascular health outcomes have been reported by previous studies.

Objective: To assess the cardiovascular health of children conceived by ART.

Endometrial cavity fluid is associated with deleterious pregnancy outcomes in patients undergoing fertilization/intracytoplasmic sperm injection: a retrospective cohort study.

Background: The effects of endometrial cavity fluid (ECF) on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancy outcomes following embryo transfer (ET) are still controversial. We conducted the present study to investigate whether the presence of ECF in infertile patients scheduled to undergo IVF or ICSI was associated with pregnancy outcomes.

Methods: A retrospective cohort study design was used.

The impact of increasing land productivity on groundwater dynamics: a case study of an oasis located at the edge of the Gobi Desert.

Background: Intensification of agricultural systems may result in overexploitation of water resources in arid regions because enhanced productivity of crops is often associated with increased actual evapotranspiration (AET). The aim of this study was to quantify the effect of increased regional AET on the groundwater level in a case study of the oasis located within the Shiyang River Basin near the edge of the Gobi Desert.

Result: The results of the study show that regional AET increased during the period from 1981 to 2010 due to increasing oasis area and air temperature.