Publications by authors named "Jiana Zhang"
Article Synopsis
- Researchers explored the connection between anxiety and adult-onset isolated dystonia (AOID), revealing unknown mechanisms behind psychiatric issues in AOID patients.
- The study involved MRI scans of 69 AOID patients and 35 healthy controls, focusing on grey matter volume and brain activity using metrics like amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo).
- Findings showed that AOID patients with anxiety had significant increases in ALFF and ReHo in the left angular gyrus, with these metrics showing strong potential as biomarkers for diagnosing anxiety in this population.
Ethnopharmacological Relevance: Palmatine is a main bioactive alkaloid of Cortex Phellodendri, which has been commonly prescribed for the treatment of hyperuricemia (HUA) in China. The metabolites of palmatine were crucial to its prominent biological activity. 9-Hydroxy-8-oxypalmatine (9-OPAL) is a novel liver-mediated secondary oxymetabolite of palmatine.
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- The study investigates changes in white matter structural networks in patients with cervical dystonia (CD) compared to healthy controls using diffusion tensor imaging.
- Results indicate that patients with CD exhibit increased local efficiency and assortativity in their network, along with a significant decrease in overall network strength.
- The findings suggest a reorganization of white matter networks in CD patients, but the relationship between these changes and clinical symptoms remains unclear and requires further study.
Article Synopsis
- The thalamus, a part of the brain, is important in understanding idiopathic cervical dystonia (iCD), a condition that causes neck muscle spasms.
- Researchers used MRI scans to study 37 people with iCD compared to 37 healthy people, looking at different sections of the thalamus.
- They found that certain parts of the thalamus were smaller in people with iCD, but these size changes didn't seem to relate to the symptoms they experienced.
Article Synopsis
- The study investigates the role of different thalamic nuclei in patients with blepharospasm and blepharospasm-oromandibular dystonia, moving beyond the traditional view of the thalamus as a single structure.
- It analyzes the grey matter volume in various thalamic subregions and explores causal relationships among them to find potential neuroimaging biomarkers for distinguishing between these conditions and healthy controls.
- Results show that specific nuclei exhibited reduced grey matter volume in patients compared to healthy controls, correlating with clinical severity, and a machine learning approach achieved high accuracy in distinguishing patients from controls.
Parkinson disease (PD) is an age-dependent neurodegenerative disease with very high prevalence by age 80 years. Necroptosis is a newly identified form of programmed cell death implicated in neurodegenerative diseases, but has not yet been conclusively associated with PD. This study examined the contributions of necroptosis to PD using bioinformatics analysis.
View Article and Find Full Text PDFBackground: Bone morphogenetic protein receptor II (BMPR-II) plays an important role in tumor's invasion and proliferation. In this study, we observed the effects of small interfering RNA (siRNA) targeting bone morphogenetic protein receptor II (BMPR-II) on the biological activities of human liver cells and explore its mechanism.
Methods: The molecular sequences of three siRNA targeting BMPR-IIwere designed and synthesized.