Efficacy and safety of switching to insulin glargine 300 U/mL in people with type 2 diabetes uncontrolled on basal insulin in China: A post hoc subpopulation analysis of the INITIATION study.

Aims: To evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla-300) in people with uncontrolled type 2 diabetes (T2D) switching from another basal insulin (BI).

Materials And Methods: INITIATION was an interventional, single-arm, phase IV study conducted in China. In this post hoc subpopulation analysis, the efficacy and safety of switching to Gla-300 was investigated in individuals with uncontrolled T2D (HbA1c 7.

Alterations in the Gut Microbiota Composition in Obesity with and without Type 2 Diabetes: A Pilot Study.

Purpose: Obesity has become a major public health concern worldwide, increasing the risk of T2DM. Growing evidence indicates gut microbiota dysbiosis is related to metabolic disorders. We aimed to firstly investigate the compositional and functional features of the gut microbiome between obesity with and without T2DM in the Chinese population.

Diversities of Mechanism in Patients with VHL Syndrome and diabetes: A Report of Two Cases and Literature Review.

Background: Von Hippel-Lindau (VHL) syndrome is characterized by tumorous lesions affecting multiple organs. Pancreatic involvement in VHL syndrome can present as endocrine tumors and pancreatic cysts, which can interfere with both exocrine and endocrine functions of the pancreas. Diabetes is an uncommon complication of VHL syndrome.

Pituitary stalk interruption syndrome and liver cirrhosis associated with diabetes and an inactivating gene mutation: a case report and literature review.

Background: Pituitary stalk interruption syndrome (PSIS) is a congenital disease commonly found in patients with combined pituitary hormone deficiency (CPHD). Most PSIS patients manifest growth retardation and delayed puberty. We report a rare case of PSIS with tall stature, liver cirrhosis and diabetes, possibly caused by an inactivating gene mutation.

Exploring the nexus of green finance and renewable energy consumption: unraveling synergistic effects and spatial spillovers.

As China transitions towards a green and low-carbon energy system, it is crucial to have the support of green finance. In this study, we explore the effects of synergy and spatial spillovers in the development of green finance and the consumption of renewable energy. By taking a synergistic perspective, we aim to provide new insights for energy structure reform.

Decreased programmed cell death ligand 2-positive monocytic myeloid-derived suppressor cells and programmed cell death protein 1-positive T-regulatory cells in patients with type 2 diabetes: implications for immunopathogenesis.

Objectives: The activation of immune cells plays a significant role in the progression of type 2 diabetes. This study aimed to investigate the potential role of myeloid-derived suppressor cells (MDSCs) and T-regulatory cells (Tregs) in type 2 diabetes.

Methods: A total of 61 patients diagnosed with type 2 diabetes were recruited.

COVID-19 vaccine coverage, safety, and perceptions among patients with diabetes mellitus in China: a cross-sectional study.

Aims: Diabetes mellitus (DM), one of the most common chronic diseases in China, is a risk factor for SARS-COV-2 infection and poor prognosis of COVID-19. The COVID-19 vaccine is one of the key measures to control the pandemic. However, the actual coverage of COVID-19 vaccination and associated factors remain unclear among DM patients in China.

The concordance and discordance of diabetic kidney disease and retinopathy in patients with type 2 diabetes mellitus: A cross-sectional study of 26,809 patients from 5 primary hospitals in China.

Introduction: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) share similar pathophysiological mechanisms. However, signs of DKD may be present at diagnosis of diabetes without retinopathy. Risk factors for the development of DKD and DR may not be identical.

The feasibility and efficacy of a community-based multifactorial intervention to improve the cardiovascular risk factor control among patients with type 2 diabetes: A 2-year cluster randomized trial.

Trial Design: Our study is to investigate the feasibility and effectiveness of multiple cardiovascular factors intervention (MFI) in type 2 diabetes patients in China's primary care setting.

Methods: We performed a cluster randomized trial to compare the proportion of patients achieved the targets between usual care group (control, 9 sites, n = 868) and MFI group (8 sites, n = 739) among patients with type 2 diabetes in primary care setting. Logistic regression model with random effects was used to estimate the association of the effect of intervention and the proportion achieved the targets.

Denosumab biosimilar (LY06006) in Chinese postmenopausal osteoporotic women: A randomized, double-blind, placebo-controlled, multicenter phase III study.

Objectives: This study assessed the efficacy, safety, pharmacokinetics (PK), and immunogenicity profiles of a denosumab biosimilar (LY06006) in Chinese postmenopausal osteoporotic women with a high risk of fracture.

Methods: In this multicenter, randomized, double-blind, placebo-controlled, phase 3 trial, 448 postmenopausal women aged 50-85 years with osteoporosis were enrolled at 49 centers in China and were randomly assigned (3:1) to receive 60 ​mg of the denosumab biosimilar (LY06006) or placebo subcutaneously every 6 months for 1 year. Lumbar spine bone mineral density (BMD) change was the primary endpoint.

Promoted Carbon Monoxide Sensing Performance of a BiMnO-Based Mixed-Potential Sensor by Regulating Oxygen Vacancies.

The YSZ-based mixed-potential sensor has exhibited promising application prospects for in situ carbon monoxide (CO) monitoring owing to its excellent thermal stability. However, the way to further enhance the sensitivity and selectivity of the sensor remains challenging due to the limitation of the sensing material. In the present work, we proposed a strategy of introducing moderate oxygen vacancies in the transition metal oxide sensing material to enhance CO sensing performance.

Euglycaemic Ketoacidosis Due to Extremely Low-Calorie Intake and Dehydration After Laparoscopic Sleeve Gastrectomy in a Patient with Type 2 Diabetes.

Background: Bariatric surgery is an effective therapy for type 2 diabetes mellitus (T2DM) and obesity. Euglycaemic ketoacidosis (EKA) has been reported in patients taking sodium-glucose cotransporter 2 (SGLT2) inhibitors after bariatric surgery. Cases of T2DM complicated with EKA without SGLT2 inhibitors after bariatric surgery are rarely reported.

How do resource dependence and technological progress affect carbon emissions reduction effect of industrial structure transformation? Empirical research based on the rebound effect in China.

Under the guidance of carbon peak and carbon neutral targets, the industrial structure transformation is vital for carbon emissions reduction in China. However, there is a rebound effect of carbon emissions during the industrial structure transformation. Resource dependence and technological progress have significant impacts on industrial structure transformation and its carbon reduction effect.

Efficacy and safety benefits of iGlarLixi versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with suboptimally controlled type 2 diabetes on oral agents: The LixiLan-O-AP randomized controlled trial.

Aims: To compare the efficacy and safety of iGlarLixi with insulin glargine 100 units/mL (iGlar) and lixisenatide (Lixi), in Asian Pacific people with suboptimally controlled type 2 diabetes (T2D) on metformin with or without a second oral antihyperglycaemic drug (OAD).

Materials And Methods: LixiLan-O-AP (NCT03798054) was a 24-week multicentre study in adults (n = 878, mean age 56.0 years, mean body mass index 26.

Screening cardiovascular risk factors of diabetes patients in the primary diabetes clinics.

To evaluate the atherosclerotic cardiovascular diseases (ASCVD) risk factors in type 2 diabetes patients from the primary diabetes clinics for further comprehensive intervention in China.A cross-sectional study was conducted in 5 primary diabetes chain hospitals in Beijing, Lanzhou, Harbin, Chengdu, and Taiyuan in continuous patients with type 2 diabetes from March 2016 to December 2019. The data collected at the first visit were analyzed, and proportions of patients reached the targets (glycosylated hemoglobin [HbA1c] < 7%, blood pressure < 130/80 mm Hg, and low-density lipoprotein cholesterol [LDL-C] < 2.

Effects of UCMSCs Delivered through Different Transplantation Approaches on Acute Radiation Enteritis in Rats.

Radiation enteritis is the most common and serious complication of abdominal or pelvic radiation therapy. Mesenchymal stem cells (MSCs), as well as cell protection agents, inhibit apoptosis and promote the proliferation of injured tissues. 3 human umbilical cords MSCs (UCMSCs) were injected into the tail vein or peritoneal cavity of a rat model of radiation enteritis.

Industrial Structure Adjustment and Regional Green Development from the Perspective of Mineral Resource Security.

Mineral resource security is the premise and foundation of the regional green rise strategy. And the adjustment of industrial structure is an effective way to relieve the pressure of the current green economy transformation. Based on the Shift-share Method and the Spatial Durbin model, this paper takes 30 regions in China from 2006 to 2017 as examples to study the impact of industrial structure adjustment on China's green development from the perspective of mineral resource security.

New clinical screening strategy to distinguish variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population.

Objective: Maturity-onset diabetes of the young caused by hepatocyte nuclear factor-1 alpha () variants (-MODY) is a common form of monogenetic diabetes. Although patients with -MODY might specifically benefit from sulfonylurea treatment, available methods for screening this specific type of diabetes are not cost-effective. This study was designed to establish an optimized clinical strategy based on multiple biomarkers to distinguish patients with -MODY from clinically diagnosed early-onset type 2 diabetes (EOD) for genetic testing in a Chinese population.

High NH selectivity of NiFeO sensing electrode for potentiometric sensor at elevated temperature.

NiFeO was synthesized using sol-gel method for sensing electrode material of YSZ based ammonia sensor. NiFeO-SEs sintered at 1100 °C, 1150 °C and 1200 °C were characterized by XRD, the BET method and ESEM. By testing the NH response of different sensors at 650 °C, it was observed that the 1150 °C sintered sensor had the largest response value (-104.