Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project.

Aims: The role of tea consumption in the primary prevention of atherosclerotic cardiovascular disease remains unclear in cohort studies. This prospective cohort study aimed to investigate the associations of tea consumption with the risk of atherosclerotic cardiovascular disease and all-cause mortality.

Methods: We included 100,902 general Chinese adults from the project of Prediction for ASCVD Risk in China (China-PAR) in 15 provinces across China since 1998.

Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway.

The occurrence and development of prostate cancer (PCa) is complex, and the related mechanism is not fully understood. Current studies have found that extracellular vesicles (EVs) and circular RNAs (circRNAs) have important functions in various tumours and other diseases. In this study, the detection of circRNAs in PCa showed that circ_SLC19A1 was increased in PCa cells and their secreted EVs.

Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project.

Objective: To study the effect of long term exposure to ambient fine particulate matter of diameter ≤2.5 μm (PM) on the incidence of total, ischemic, and hemorrhagic stroke among Chinese adults.

Design: Population based prospective cohort study.

Obstructive sleep apnea and risk of type 2 diabetes mellitus: A systematic review and dose-response meta-analysis of cohort studies.

Background: This meta-analysis was performed to quantitatively evaluate the dose-response association between obstructive sleep apnea (OSA) and risk of type 2 diabetes mellitus (T2DM).

Methods: PubMed, Embase, and Web of Science were searched up to 12 December 2018 for articles that assessed the OSA-T2DM association. Random effects models were used to analyze the quantitative association between OSA and risk of T2DM.

Blood species identification based on deep learning analysis of Raman spectra.

Blood analysis is an indispensable means of detection in criminal investigation, customs security and quarantine, anti-poaching of wildlife, and other incidents. Detecting the species of blood is one of the most important analyses. In order to classify species by analyzing Raman spectra of blood, a recognition method based on deep learning principle is proposed in this paper.

Correction to: endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia.

The authors apologize that in our published paper entitled "Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia" Cell and Tissue Research (Published online: 22 October 2019).

Realization of a Metallic State in 1T-TaS_{2} with Persisting Long-Range Order of a Charge Density Wave.

Metallization of 1T-TaS_{2} is generally initiated at the domain boundary of a charge density wave (CDW), at the expense of its long-range order. However, we demonstrate in this study that the metallization of 1T-TaS_{2} can be also realized without breaking the long-range CDW order upon surface alkali doping. By using scanning tunneling microscopy, we find the long-range CDW order is always persisting, and the metallization is instead associated with additional in-gap excitations.

Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway.

Prostate cancer (PCa) is the second leading cause of death in men, and current studies have shown that circular RNAs (circRNAs) play important roles in its occurrence and development. Detection of circRNAs in PCa cells showed that circ_KATNAL1 is down-regulated, mainly located in the cytoplasm, and contains multiple binding sites of miR-145-3p, which is an anticancer miRNA. RNA immunoprecipitation with anti-AGO2 antibody, RNA pull-down assays with biotin-labeled circ_KATNAL1 probe or an miR-145-3p mimic, and dual luciferase reporter gene assays confirmed that circ_KATNAL1 binds directly to miR-145-3p in cells, and that , which is highly expressed in many types of tumors, is an important target gene of miR-145-3p.

Multifunctional PVDF/CNT/GO mixed matrix membranes for ultrafiltration and fouling detection.

Membrane fouling can be effectively addressed by modifying the membrane to realize anti-fouling capability together with real-time fouling detection. Here, we present the synthesis and water treatment testing of a promising candidate for this application, a composite membrane of polyvinylidene fluoride (PVDF) and functionalized carbon nano-materials prepared by a facile phase inversion method. The synergistic effect of oxidized multi-walled carbon nanotubes (OMWCNTs) and graphene oxide (GO) enabled better surface pore structures, higher surface roughness, hydrophilicity, and better antifouling property as compared with that of pristine PVDF membranes.

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting high dose methotrexate associated acute kidney injury in children with acute lymphoblastic leukemia.

Purpose: The present study was aimed at assessing the value of serum NGAL in identifying early acute kidney injury induced by HDMTX.

Methods: Children aged 1-14 years with newly diagnosed ALL receiving MTX over 3 g/m were enrolled. Serum NGAL concentrations, serum creatinine (Scr) and MTX concentrations were measured.

Association of Lipids With Ischemic and Hemorrhagic Stroke: A Prospective Cohort Study Among 267 500 Chinese.

Background and Purpose- Previous results on the association between lipids and stroke were controversial. We investigated the association of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C ), high-density lipoprotein cholesterol (HDL-C), and triglyceride with stroke. Methods- Six cohort studies in China with 267 500 participants were included.

Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for Tracking of Protein Delivery in Cancer Therapy.

monitoring of cargo protein delivery is critical for understanding the pharmacological efficacies and mechanisms during cancer therapy, but it still remains a formidable challenge because of the difficulty in observing nonfluorescent proteins at high resolution and sensitivity. Here we report an outer-frame-degradable nanovehicle featuring near-infrared (NIR) dual luminescence for real-time tracking of protein delivery . Upconversion nanoparticles (UCNPs) and fluorophore-doped degradable macroporous silica (DS) with spectral overlap were coupled to form a core-shell nanostructure as a therapeutic protein nanocarrier, which was eventually enveloped with a hyaluronic acid (HA) shell to prevent protein leakage and for recognizing tumor sites.

Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia.

Preeclampsia (PE) development is often associated with placental immune and inflammatory dysregulation, as well as endoplasmic reticulum (ER) stress. However, the mechanisms linking ER stress and inflammatory dysregulation to PE have not been elucidated. It has been reported that thioredoxin-interacting protein (TXNIP), which can bind with and activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome, is a key point in immune regulation.

A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model.

Cucurbitacin B (CuB), a highly cytotoxic constituent of the Cucurbitaceae plant, was identified to exhibit potent inhibitory activity against human cancer cells as well as normal cells. This disadvantage hampers the possibility of developing this compound into an anticancer drug candidate. In this work, several bioreductive prodrugs of CuB were designed to reduce toxicity to normal cells while maintaining the cytotoxic effect to cancer cells.

Association of hypertriglyceridemic waist-to-height ratio and its dynamic status with incident hypertension: the Rural Chinese Cohort Study.

Objective: We aimed to evaluate whether hypertriglyceridemic waist-to-height ratio (HWHtR) and its dynamic status was associated with hypertension (HTN).

Methods: We examined data for 10 312 nonhypertensive participants aged at least 18 years from the Rural Chinese Cohort Study at the baseline examination who were followed until 2014 with a median follow-up of 6 years. HWHtR was defined by combined triglyceride level and waist-to-height ratio (WHtR).

Least-squares calibration method for double-grating interferometers used in measurement of long-focal-length lenses.

In this paper, we propose a new calibration method for long-focal-length measurement using a double-grating interferometer. A numerical analysis of the relative error in measurement proves that the main factor affecting accuracy is the angle of inclination between grating grids. Hence, we present a least-squares calibration method using a series of lenses to correct this error.

Covered versus uncovered stent insertion for malignant superior vena cava obstruction.

To determine whether covered or uncovered stent insertion achieved better clinical efficacy when used to treat malignant superior vena cava (SVC) obstruction (SVCO). A total of 64 patients with malignant SVCO underwent stent insertion between January 2011 and March 2018 at our center. Of these, 34 were treated via uncovered stent insertion while 30 were treated via covered stent insertion.

An oleanolic acid derivative reduces denervation-induced muscle atrophy via activation of CNTF-mediated JAK2/STAT3 signaling pathway.

Denervation caused by sciatic nerve injury has brought great harm to the patients, especially denervation-induced muscle atrophy. The body stress produces a large number of Schwann cells when the sciatic nerve is injured, and the cells secrete some cytokines including ciliary neurotrophic factor (CNTF) that not only play a role in promoting the repair of sciatic nerve, but also maintain the normal physiological function of the muscles surrounding the damaged nerves. CNTF upregulates janus kinase 2 (JAK2) and signal transducers and activators of transcription 3 (STAT3) signals in myoblasts, and consequently accelerates the proliferation and differentiation of myoblasts.

[Relationship of PTEN/PI3K/AKT Signaling Pathway Protein Expression with Apoptosis and Drug-resistance of Children's ALL Primary Cells Treated with Daunorubicin].

Objective: To investigate the relationship of PTEN/PI3K/AKT signaling pathway protein expression with apoptosis and drug-resistance of children's ALL primary cells treated with daunorubicin (DNR).

Methods: The bone marrow mononuclear cells in newly diagnosed and untreated B-ALL children were collected and cultured. After the treatment of primary-cultured cells with DNR of final concentration 0.

Dynamic phase-deforming interferometry: suppression of errors from vibration and air turbulence.

In this Letter, dynamic phase-deforming interferometry (PDI) is proposed to solve the impact of environmental vibration and air turbulence on the measurement accuracy. Two interference passes, namely, the measurement pass (MP) and carrier-frequency pass (CP), are constructed, utilizing one detector to acquire the fringe patterns of the two passes simultaneously. The relative deformation phases of the CP fringe patterns are calculated with the Fourier transform method; then the phase extraction of the MP is performed via the least squares method to obtain the final phase distribution.

Predicting 10-Year and Lifetime Stroke Risk in Chinese Population.

Background and Purpose- Risk assessment is essential for the primary prevention of stroke. However, the current available tools derived from Chinese populations are insufficient for individualized 10-year and lifetime stroke risk prediction. Our study aims to develop and validate personalized 10-year and lifetime stroke risk equations incorporating 4 large Chinese cohorts.

Prognostic Value of the PARIS Thrombotic Risk Score for 2-Year Mortality After Percutaneous Coronary Intervention.

The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score is a novel score for predicting the risk of coronary thrombotic events after percutaneous coronary intervention (PCI). We assessed the prognostic value of this score for mortality in patients with PCI. In this prospective, observational study, we enrolled 10 724 consecutive patients underwent PCI.

A novel oleanolic acid derivative HA-19 ameliorates muscle atrophy via promoting protein synthesis and preventing protein degradation.

Muscle atrophy refers to a decrease in the size of muscles in the body, occurs in certain muscles with inactivity in many diseases and lacks effective therapies up to date. Natural products still play an important role in drug discovery. In the present study, derivatives of a natural product, oleanolic acid, were screened with myoblast differentiation and myotube atrophy assays, respectively.

Polysulfone-graft-4'- aminobenzo-15-crown-5-ether based tandem membrane chromatography for efficient adsorptive separation of lithium isotopes.

Adsorptive membrane-based chromatography can provide the high separation efficiency common to column chromatography but at a lower working pressure. Herein, a novel membrane chromatography system for lithium isotope adsorptive separation is reported. It uses polysulfone-graft-4'-aminobenzo-15-crown-5-ether (PSf-g-AB15C5) porous membranes (0.

Ultra-low graphene oxide loading for water permeability, antifouling and antibacterial improvement of polyethersulfone/sulfonated polysulfone ultrafiltration membranes.

The aqueous dispersion of graphene oxide (GO) was employed as additive to fabricate antifouling and antibacterial polyethersulfone (PES)/sulfonated polysulfone (SPSf)/GO mixed matrix membranes (MMMs) by the non-solvent induced phase separation (NIPS). The effect of different amounts of GO on the morphology and performance of MMMs were studied. The results showed that the casting solution exhibited an increasing trend in viscosity with increment in GO concentration (from 0 to 0.