Deformation monitoring and safety stability evaluation study of high-altitude limestone dumps.

We employed synthetic aperture radar interferometry (InSAR) to assess the slope stability of a high-altitude landfill in Sangri County, Shannan, Tibet. To address the unique climatic conditions of high-altitude regions, the InSAR deformation monitoring model was enhanced to mitigate the effects of temperature and rainfall. The accuracy of InSAR monitoring in high-elevation slopes was validated by comparison with GNSS RTK measurements.

A Review of the Impact of Graphene Oxide on Cement Composites.

Graphene oxide (GO) has attracted significant attention as a nano-reinforcement for cement-based materials, owing to its exceptional mechanical properties and abundant surface functional groups. However, the precise mechanisms governing its effects in cement composites remain inadequately understood due to inconsistencies and gaps in the existing literature. This review conducts a comprehensive analysis of the dispersion and reinforcement effects of GO in cement materials, focusing on three key areas: (1) challenges associated with achieving uniform dispersion of GO in the high-pH environment of cement slurries and potential strategies to address them; (2) the influence of GO on the macroscopic properties of cementitious composites, including workability, load-bearing capacity, flexural strength, fracture resistance, and durability; and (3) the reinforcement mechanisms of GO, encompassing its role in hydration kinetics, alterations to the calcium-silicate-hydrate (C-S-H) structure, and bonding interactions at the cement matrix interface.

Analysis of the contractile work of a single cardiomyocyte by atomic force microscopy.

Atomic force microscopy (AFM) is widely used for the imaging and characterization of biological cells because of its nanoscale spatial resolution and force resolution. However, in the previous studies, the inability to effectively detect the contractile work of cardiomyocytes and the 3D dynamic expressions of their contraction and relaxation behaviors posed significant challenges. Therefore, this work presents a method for the analysis of the contractile work of a single cardiomyocyte by AFM.

Clinical effectiveness of unilateral single-armed vasoepididymostomy in obstructive azoospermia: a single-center experience.

Background: Vasoepididymostomy (VE) is an important surgical treatment to achieve natural conception for patients with obstructive azoospermia (OA), and only unilateral VE can be performed under certain conditions, such as OA patients with congenital unilateral absence of the vas deferens (CUAVD) and some acquired OA. There is a lack of relevant reports assessing the clinical outcomes of unilateral VE in OA patients with different causes. This study is aimed to describe the clinical features and evaluate treatments and outcomes of unilateral single-armed VE in OA patients.

Radial mechanical properties of deoxyribonucleic acid molecules.

Given the small diameter of deoxyribonucleic acid (DNA), the difficulty in studying its radial mechanical properties laid in the challenge of applying a precise and controlled small force. In this work, the radial mechanical properties of DNA were measured in the AFM. DNA adhesion properties were analyzed through force-distance curves and adhesion images.

Development and Validation of a Deep Learning System to Differentiate HER2-Zero, HER2-Low, and HER2-Positive Breast Cancer Based on Dynamic Contrast-Enhanced MRI.

Background: Previous studies explored MRI-based radiomic features for differentiating between human epidermal growth factor receptor 2 (HER2)-zero, HER2-low, and HER2-positive breast cancer, but deep learning's effectiveness is uncertain.

Purpose: This study aims to develop and validate a deep learning system using dynamic contrast-enhanced MRI (DCE-MRI) for automated tumor segmentation and classification of HER2-zero, HER2-low, and HER2-positive statuses.

Study Type: Retrospective.

A multi-functional platform for stimulating and recording electrical responses of SH-SY5Y cells.

In recent years, multifunctional cell regulation on a single chip has become an imperative need for cell research. In this study, a novel multi-functional micro-platform integrating wireless electrical stimulation, mechanical stimulation and electrical response recording of cells was proposed. Controlling cell fate by photoexcited radio stimulation of cells on photosensitive films can precisely orchestrate biological activities.

: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma.

Despite the generally favorable prognosis of PTC (Papillary Thyroid Carcinoma), it can still exhibit aggressive behavior and lead to patient mortality. (interaction protein for cytohesin exchange factors 1) has emerged as a critical player in cell signaling related to proliferation and migration in cancer progression. Our research aimed to determine whether is a key gene in PTC, elucidate its possible molecular mechanisms and ultimately search for new targets.

Amelioration of experimental autoimmune encephalomyelitis by exogenous soluble PD-L1 is associated with restraining dendritic cell maturation and CCR7-mediated migration.

Dendritic cells (DCs) orchestrate both immune activation and immune tolerance in multiple sclerosis (MS). Manipulating the phenotypes and functions of DCs to boost their tolerogenic potential is an appealing strategy for treating MS and its animal model experimental autoimmune encephalomyelitis (EAE). Programmed cell death 1 (PD-1) delivers the immunoinhibitory signals by interacting with PD-1 ligand 1 (PD-L1), which plays a critical role in maintaining immune tolerance.

Probing action potentials of single beating cardiomyocytes using atomic force microscopy.

This paper presents a method for using atomic force microscopy to probe action potentials of single beating cardiomyocytes at the nanoscale. In this work, the conductive tip of an atomic force microscope (AFM) was used as a nanoelectrode to record the action potentials of self-beating cardiomyocytes in both the non-constant force contact mode and the constant force contact mode. An electrical model of a tip-cell interface was developed and the indentation force effect on the seal of an AFM conductive tip-cell membrane was theoretically analyzed.

Experiments on Chloride Binding and Its Release by Sulfates in Cementitious Materials.

The aim of this study was to experimentally investigate the process of chloride binding and its sulfate-induced release in cementitious materials. The cementitious materials were replaced with hardened cement paste particles (HCPs) with water-to-cement ratios (w/c) of 0.35 and 0.

The clinical characteristics and pathogenic variants of primary pigmented nodular adrenocortical disease in 210 patients: a systematic review.

Aims: Primary pigmented nodular adrenocortical disease (PPNAD), as a rare kind of Cushing's syndrome, is frequently misdiagnosed. To get a better understanding of the disease, we analyzed the clinical characteristics and pathogenic variants of PPNAD.

Methods: Databases were searched, and the pathogenic variants and clinical manifestations of patients were summarized from the relevant articles.

Cell recognition based on features extracted by AFM and parameter optimization classifiers.

Intelligent technology can assist in the diagnosis and treatment of disease, which would pave the way towards precision medicine in the coming decade. As a key focus of medical research, the diagnosis and prognosis of cancer play an important role in the future survival of patients. In this work, a diagnostic method based on nano-resolution imaging was proposed to meet the demand for precise detection methods in medicine and scientific research.

Biorthogonal Dynamical Quantum Phase Transitions in Non-Hermitian Systems.

By utilizing biorthogonal bases, we develop a comprehensive framework for studying biorthogonal dynamical quantum phase transitions in non-Hermitian systems. With the help of the previously overlooked associated state, we define the automatically normalized biorthogonal Loschmidt echo. This approach is capable of handling arbitrary non-Hermitian systems with complex eigenvalues and naturally eliminates the negative value of Loschmidt rate obtained without the biorthogonal bases.

C/EBPβ-Lin28a positive feedback loop triggered by C/EBPβ hypomethylation enhances the proliferation and migration of vascular smooth muscle cells in restenosis.

Background: The main cause of restenosis after percutaneous transluminal angioplasty (PTA) is the excessive proliferation and migration of vascular smooth muscle cells (VSMCs). Lin28a has been reported to play critical regulatory roles in this process. However, whether CCAAT/enhancer-binding proteins β (C/EBPβ) binds to the Lin28a promoter and drives the progression of restenosis has not been clarified.

Renal effects and safety between Asian and non-Asian chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists.

Background: Asians bear a heavier burden of chronic kidney disease (CKD), a common comorbidity of type 2 diabetes mellitus (T2DM), than non-Asians. Nonsteroidal mineralocorticoid receptor antagonists (MRAs) have garnered attention for their potential advantages in renal outcomes. Nevertheless, the impact on diverse ethnic groups remains unknown.

Virtual screening and biological evaluation of natural products as urate transporter 1 (URAT1) inhibitors.

Hyperuricemia is mainly caused by insufficient renal urate excretion. Urate transporter 1 (URAT1), an organic anion transporter, is the main protein responsible for urate reabsorption. In this study, we utilized artificial intelligence-based AlphaFold2 program to construct URAT1 structural model.

Cardiorenal Benefits of Finerenone in Different Races and Kidney Function in Patients with Chronic Kidney Disease.

Background: The mineralocorticoid receptor plays an important pathophysiological role in cardiorenal diseases by causing inflammation and fibrosis. Mineralocorticoid receptor antagonists (MRAs) are well known in treating cardiovascular disease and diverse nephropathies. However, the first-generation MRA (spironolactone) and the second-generation MRA (eplerenone) remain underutilized because of the risk of inducing severe adverse events.

Determining the degree of chromosomal instability in breast cancer cells by atomic force microscopy.

Chromosomal instability (CIN) is a source of genetic variation and is highly linked to the malignance of cancer. Determining the degree of CIN is necessary for understanding the role that it plays in tumor development. There is currently a lack of research on high-resolution characterization of CIN and the relationship between CIN and cell mechanics.

Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Introduction: Tirzepatide is a novel hypoglycemic agent for type 2 diabetes mellitus (T2DM). However, the pathophysiology of T2DM in Asians is different from that in non-Asians, and there is no evidence to explain the differences in the efficacy and safety of tirzepatide between different races.

Methods: A literature search was conducted in China National Knowledge Infrastructure (CNKI), PubMed, Cochrane Library, Clinical Trials.

High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?

Background: Proximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor markers, CD133 was reported to indicate the regeneration of dedifferentiated PTCs in acute kidney disease. However, its role in chronic DKD is unclear.

Virtual screening of natural products targeting ubiquitin-specific protease 7.

Ubiquitin-specific protease 7 (USP7) is a promising prognostic and druggable target for cancer therapy. Inhibition of USP7 can activate the MDM2-P53 signaling pathway, thereby promoting cancer cell apoptosis. This study based on watvina molecular docking of virtual screening method and biological evaluation found the new USP7 inhibitors targeting catalytic active site.