Flexible sensing offers real-time force monitoring, presenting a versatile and effective solution for dexterous manipulation, healthcare, environmental exploration, and perception of physical properties. Nonetheless, a limitation of many existing flexible force sensors stems from their isotropic structure or material properties, preventing them from simultaneously detecting both the direction and magnitude of the applied force. Herein, a high-performance 3D force sensor based on orthogonal multimodal sensing, the cancellation principle, and the strain effect is proposed.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
The body structures and motion stability of worm-like and snake-like robots have garnered significant research interest. Recently, innovative serial-parallel hybrid segmented robots have emerged as a fundamental platform for a wide range of motion modes. To address the hyper-redundancy characteristics of these hybrid structures, we propose a novel caterpillar-inspired Stable Segment Update (SSU) gait generation approach, establishing a unified framework for multi-segment robot gait generation.
View Article and Find Full Text PDFSoil salinization is a serious threat to the ecological environment and sustainable agricultural development in the arid regions of northwest China. Optimal soil salinization amelioration methods were eagerly explored under different soil salinity levels. Sesbania and hairy vetch are salt-tolerant plants, and green manure improved the saline environment.
View Article and Find Full Text PDFAim: Previous studies have demonstrated that Ras-related GTP-binding protein Rab10 (Rab10) plays a role in psychostimulant-induced behavioral effects. In this study, we showed that Rab10 in the nucleus accumbens (NAc) of male animals affects the development of cocaine-induced behavioral effects, which are associated with the plasma membrane expression of the GABA heteroreceptor (GABAR).
Methods: We performed flow cytometry, immunoendocytosis, pHluorin activity analysis, electrophysiology analysis, and open-field testing to explore the role of Rab10 in modulating the membrane expression and function of GABAR and its regulatory effect on cocaine-induced behavioral effects.
Propose: The aim of this study was to evaluate the clinical application value of 18 F-FGln PET/CT in glioma.
Patients And Methods: Patients with suspected gliomas by MRI were included in this study. Static and/or dynamic brain 18 F-FGln PET/CT was performed.
Background: Bruceine A(BA) has many pharmacological activities and significantly inhibits fibrosis in keloid fibroblasts. However, the underlying mechanisms have not yet been fully elucidated.
Objective: This study aimed to investigate the effects of BA on pulmonary fibrosis(PF) and explore its underlying mechanisms.
Aiming at the problem of overbrightness of the target simulator background for LED backlight panel illumination, a 5° aperture angle-matched collimated illumination method for the target simulator is proposed based on the study of the dark-state leakage of the LCD display device and the scattered stray light of the system. After simulation analysis the method can make the display contrast increase by 3.1 times and solve the problem of dark targets being drowned by the background bright light, which exists in the LED illumination target simulator.
View Article and Find Full Text PDFAiming at the problem that the error of multi-optical axis alignment is difficult to control in the simulation calibration test, a multi-optical axis dynamic compensation alignment method for the space environment simulation system is proposed. The effect of optical axis disturbance on the signal detection link was analyzed to obtain the alignment accuracy requirements, the optical axis alignment error compensation mechanism was established, the target simulation system with long pupil distance was designed, the alignment error transfer model based on topology structure was constructed, and the test prototype was built. The test results show that the static attitude alignment resolution is better than 3" and the position alignment resolution is better than 11µm.
View Article and Find Full Text PDFACS Appl Mater Interfaces
November 2024
In this study, a novel ultramicroporous pillar-layered Ni-LAP-NH [Ni(l-asp)(Pz-NH)] (l-asp = l-aspartic acid, Pz-NH = aminopyrazine) membranes on porous α-AlO tubes with high performance and good thermal stability was first fabricated using isostructural Ni-LAP[Ni(l-asp)(Pz)] (Pz = pyrazine) crystals as seeds. Utilizing the principle of reticular chemistry, here, we introduced the active amino side group into the Ni-LAP frameworks by replacing the pillar-layered ligand Pz with Pz -NH while maintaining the original Ni-LAP small pore size, and the amino side group induced a "steric hindrance" effect and the physical adsorption affinity, which synergistically delayed CO penetration. It was found that the preferential (111) orientation Ni-LAP-NH membrane (Z10) exhibited a high H/CO separation performance with a separation factor of 41.
View Article and Find Full Text PDFThe clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions. Among emerging strategies, extracellular vesicles (EVs) have shown promise as an acellular approach for bone regeneration. However, their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.
View Article and Find Full Text PDFPoria cocos and its surface layer of Poria cocos (Schw.) Wolf (Polyporaceae), are used in traditional Chinese medicine for its diuretic and renoprotective effects. Phytochemical studies have shown that lanostane and 3,4-seco-lanostane tetracyclic triterpenoids are the main components of P.
View Article and Find Full Text PDFBackground: Lactate is gradually proved as the essential regulator in intercellular signal transduction, energy metabolism reprogramming, and histone modification. This study aims to clarify the diagnosis value of lactate metabolism-related genes in osteoarthritis (OA).
Methods: Lactate metabolism-related genes were retrieved from the MSigDB.
Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from (Schenk) Wight exerts antidiabetic and renoprotective effects. However, the effects of CPhGs on DN remain incompletely understood.
View Article and Find Full Text PDFMicromachines (Basel)
September 2024
Temperature exerts a profound influence on the fidelity of photosensors, making the attainment of reliable temperature compensation a formidable task within engineering realms. This research delves into the intricacies of photosensors used in high-precision accelerometers, proposing an innovative, high-precision, adaptive, closed-loop compensation mechanism. Our design stands in stark contrast to traditional open-loop models, demonstrating superior performance by achieving a remarkable reduction in compensation error-nearly 98%.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
November 2024
A speech intelligibility (SI) prediction model is proposed that includes an auditory preprocessing component based on the physiological anatomy and activity of the human ear, a hierarchical spiking neural network, and a decision back-end processing based on correlation analysis. The auditory preprocessing component effectively captures advanced physiological details of the auditory system, such as retrograde traveling waves, longitudinal coupling, and cochlear nonlinearity. The ability of the model to predict data from normal-hearing listeners under various additive noise conditions was considered.
View Article and Find Full Text PDFHealth Qual Life Outcomes
September 2024
Background: This study aimed to synthesize and quantitatively examine Health State Utility Values (HSUVs) for Type 2 Diabetes Mellitus (T2DM) and its complications, providing a robust meta-regression framework for selecting appropriate HSUV estimates.
Method: We conducted a systematic review to extract HSUVs for T2DM and its complications, encompassing various influencing factors. Relevant literature was sourced from a review spanning 2000-2020, supplemented by literature from PubMed, Embase, and the Web of Science (up to March 2024).
Aims: This study investigated vancomycin-microbubbles (Vm-MBs) and meropenem (Mp)-MBs with ultrasound-targeted microbubble destruction (UTMD) to disrupt biofilms and improve bactericidal efficiency, providing a new and promising strategy for the treatment of device-related infections (DRIs).
Methods: A film hydration method was used to prepare Vm-MBs and Mp-MBs and examine their characterization. Biofilms of methicillin-resistant (MRSA) and were treated with different groups.