Publications by authors named "JianHua Yang"

Flexible sensing offers real-time force monitoring, presenting a versatile and effective solution for dexterous manipulation, healthcare, environmental exploration, and perception of physical properties. Nonetheless, a limitation of many existing flexible force sensors stems from their isotropic structure or material properties, preventing them from simultaneously detecting both the direction and magnitude of the applied force. Herein, a high-performance 3D force sensor based on orthogonal multimodal sensing, the cancellation principle, and the strain effect is proposed.

View Article and Find Full Text PDF

The body structures and motion stability of worm-like and snake-like robots have garnered significant research interest. Recently, innovative serial-parallel hybrid segmented robots have emerged as a fundamental platform for a wide range of motion modes. To address the hyper-redundancy characteristics of these hybrid structures, we propose a novel caterpillar-inspired Stable Segment Update (SSU) gait generation approach, establishing a unified framework for multi-segment robot gait generation.

View Article and Find Full Text PDF

Soil salinization is a serious threat to the ecological environment and sustainable agricultural development in the arid regions of northwest China. Optimal soil salinization amelioration methods were eagerly explored under different soil salinity levels. Sesbania and hairy vetch are salt-tolerant plants, and green manure improved the saline environment.

View Article and Find Full Text PDF

Aim: Previous studies have demonstrated that Ras-related GTP-binding protein Rab10 (Rab10) plays a role in psychostimulant-induced behavioral effects. In this study, we showed that Rab10 in the nucleus accumbens (NAc) of male animals affects the development of cocaine-induced behavioral effects, which are associated with the plasma membrane expression of the GABA heteroreceptor (GABAR).

Methods: We performed flow cytometry, immunoendocytosis, pHluorin activity analysis, electrophysiology analysis, and open-field testing to explore the role of Rab10 in modulating the membrane expression and function of GABAR and its regulatory effect on cocaine-induced behavioral effects.

View Article and Find Full Text PDF

Propose: The aim of this study was to evaluate the clinical application value of 18 F-FGln PET/CT in glioma.

Patients And Methods: Patients with suspected gliomas by MRI were included in this study. Static and/or dynamic brain 18 F-FGln PET/CT was performed.

View Article and Find Full Text PDF

Background: Bruceine A(BA) has many pharmacological activities and significantly inhibits fibrosis in keloid fibroblasts. However, the underlying mechanisms have not yet been fully elucidated.

Objective: This study aimed to investigate the effects of BA on pulmonary fibrosis(PF) and explore its underlying mechanisms.

View Article and Find Full Text PDF

Aiming at the problem of overbrightness of the target simulator background for LED backlight panel illumination, a 5° aperture angle-matched collimated illumination method for the target simulator is proposed based on the study of the dark-state leakage of the LCD display device and the scattered stray light of the system. After simulation analysis the method can make the display contrast increase by 3.1 times and solve the problem of dark targets being drowned by the background bright light, which exists in the LED illumination target simulator.

View Article and Find Full Text PDF

Aiming at the problem that the error of multi-optical axis alignment is difficult to control in the simulation calibration test, a multi-optical axis dynamic compensation alignment method for the space environment simulation system is proposed. The effect of optical axis disturbance on the signal detection link was analyzed to obtain the alignment accuracy requirements, the optical axis alignment error compensation mechanism was established, the target simulation system with long pupil distance was designed, the alignment error transfer model based on topology structure was constructed, and the test prototype was built. The test results show that the static attitude alignment resolution is better than 3" and the position alignment resolution is better than 11µm.

View Article and Find Full Text PDF

In this study, a novel ultramicroporous pillar-layered Ni-LAP-NH [Ni(l-asp)(Pz-NH)] (l-asp = l-aspartic acid, Pz-NH = aminopyrazine) membranes on porous α-AlO tubes with high performance and good thermal stability was first fabricated using isostructural Ni-LAP[Ni(l-asp)(Pz)] (Pz = pyrazine) crystals as seeds. Utilizing the principle of reticular chemistry, here, we introduced the active amino side group into the Ni-LAP frameworks by replacing the pillar-layered ligand Pz with Pz -NH while maintaining the original Ni-LAP small pore size, and the amino side group induced a "steric hindrance" effect and the physical adsorption affinity, which synergistically delayed CO penetration. It was found that the preferential (111) orientation Ni-LAP-NH membrane (Z10) exhibited a high H/CO separation performance with a separation factor of 41.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on the protein p53, which plays a key role in tumor suppression and is linked to the frequently mutated TP53 gene in many cancers, highlighting its multiple functions in regulating various cellular processes related to cancer development.
  • The paper aims to provide a comprehensive summary of p53's roles in the tumor microenvironment (TME), mA modification, and numerous forms of programmed cell death (PCD), which are crucial for cancer progression and metastasis.
  • It discusses important interactions between cancer immunity, cell death mechanisms, and RNA modifications, while outlining the complex roles of both wild-type and mutant p53, ultimately aiming to inform the development of new cancer therapies.
View Article and Find Full Text PDF

The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions. Among emerging strategies, extracellular vesicles (EVs) have shown promise as an acellular approach for bone regeneration. However, their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.

View Article and Find Full Text PDF

Poria cocos and its surface layer of Poria cocos (Schw.) Wolf (Polyporaceae), are used in traditional Chinese medicine for its diuretic and renoprotective effects. Phytochemical studies have shown that lanostane and 3,4-seco-lanostane tetracyclic triterpenoids are the main components of P.

View Article and Find Full Text PDF

Background: Lactate is gradually proved as the essential regulator in intercellular signal transduction, energy metabolism reprogramming, and histone modification. This study aims to clarify the diagnosis value of lactate metabolism-related genes in osteoarthritis (OA).

Methods: Lactate metabolism-related genes were retrieved from the MSigDB.

View Article and Find Full Text PDF

Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from (Schenk) Wight exerts antidiabetic and renoprotective effects. However, the effects of CPhGs on DN remain incompletely understood.

View Article and Find Full Text PDF

Temperature exerts a profound influence on the fidelity of photosensors, making the attainment of reliable temperature compensation a formidable task within engineering realms. This research delves into the intricacies of photosensors used in high-precision accelerometers, proposing an innovative, high-precision, adaptive, closed-loop compensation mechanism. Our design stands in stark contrast to traditional open-loop models, demonstrating superior performance by achieving a remarkable reduction in compensation error-nearly 98%.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the effects of Panax notoginseng saponins (PNS) on diabetic kidney disease (DKD) using network pharmacology, molecular docking, and animal experiments.
  • Key targets identified for PNS include AKT1, STAT3, and others, with relevant pathways related to cancer and signaling highlighted in the analysis.
  • Animal trials showed that PNS significantly lowered blood glucose levels and improved kidney damage in diabetic mice, indicating its potential therapeutic effect on DKD.
View Article and Find Full Text PDF
Article Synopsis
  • The electromagnetic middle-ear implant (MEI) is a new device designed to help with sensorineural and mixed hearing loss, and its effectiveness relies on where the transducer stimulates the ear.
  • Researchers used a human-ear finite element model to evaluate how different stimulation sites (umbo, incus body, incus long process, and stapes) influence the motion of the stapes bone, comparing the results to experimental data.
  • Findings indicate that low and middle frequencies show similar stapes motion with certain stimulation sites compared to normal hearing, while at high frequencies, one site aligns closely with normal hearing responses; additionally, the direction of stimulation affects sound pressure levels differently than motion types.
View Article and Find Full Text PDF
Article Synopsis
  • The rise of smart homes creates a need for devices that can detect ammonia (NH) levels in real-time to ensure food quality and prevent health risks.
  • Limited studies have successfully created stable, continuous monitoring systems for ammonia.
  • This report introduces a new nitrogen-doped TiCT gas sensor that offers promising solutions for detecting food spoilage and ammonia leaks, supported by theoretical calculations demonstrating improved performance.
View Article and Find Full Text PDF
Article Synopsis
  • - A new, cost-effective method for measuring ultra-low-frequency vibrations (below 1 Hz) using RFID technology is proposed, which significantly improves measurement capabilities in critical research fields.
  • - The RFID sensing method is validated to accurately detect vibrations as low as 0.01 Hz, with a minimal average relative error of less than 1.5%, making it reliable even across varying distances and occlusion conditions.
  • - Compared to traditional laser displacement sensors, this RFID method offers better sensitivity, a wider amplitude range, and is more adaptable to different environments, making it ideal for various engineering applications.
View Article and Find Full Text PDF

A speech intelligibility (SI) prediction model is proposed that includes an auditory preprocessing component based on the physiological anatomy and activity of the human ear, a hierarchical spiking neural network, and a decision back-end processing based on correlation analysis. The auditory preprocessing component effectively captures advanced physiological details of the auditory system, such as retrograde traveling waves, longitudinal coupling, and cochlear nonlinearity. The ability of the model to predict data from normal-hearing listeners under various additive noise conditions was considered.

View Article and Find Full Text PDF

Background: This study aimed to synthesize and quantitatively examine Health State Utility Values (HSUVs) for Type 2 Diabetes Mellitus (T2DM) and its complications, providing a robust meta-regression framework for selecting appropriate HSUV estimates.

Method: We conducted a systematic review to extract HSUVs for T2DM and its complications, encompassing various influencing factors. Relevant literature was sourced from a review spanning 2000-2020, supplemented by literature from PubMed, Embase, and the Web of Science (up to March 2024).

View Article and Find Full Text PDF
Article Synopsis
  • * The new sensor features a flexible paper-based structure that combines titanium carbide (TiCT) with MoS quantum dots, achieving a significantly higher sensitivity (16.3% at 5 ppm) and lower detection limit (12.1 ppb) than existing technologies.
  • * The design incorporates an end-sealing effect with natural compounds to protect the sensor, resulting in exceptional stability with only a 1.8% performance drop over four weeks.
View Article and Find Full Text PDF

Aims: This study investigated vancomycin-microbubbles (Vm-MBs) and meropenem (Mp)-MBs with ultrasound-targeted microbubble destruction (UTMD) to disrupt biofilms and improve bactericidal efficiency, providing a new and promising strategy for the treatment of device-related infections (DRIs).

Methods: A film hydration method was used to prepare Vm-MBs and Mp-MBs and examine their characterization. Biofilms of methicillin-resistant (MRSA) and were treated with different groups.

View Article and Find Full Text PDF
Article Synopsis
  • The study addresses the challenges of detecting ammonia (NH) at trace levels and proposes a new highly sensitive gas sensor using Ni single-atom active sites on 2D MXene nanosheets.
  • The sensor shows impressive performance with a 27.3% response to 5 ppm NH and a low theoretical detection limit of 12.1 ppb, aided by simulation analysis that highlights the unique properties of the Ni active sites.
  • The dual-channel sensing mechanism enhances sensitivity and stability, particularly under high humidity, offering a novel approach for room-temperature detection of trace gases.
View Article and Find Full Text PDF