Quercetin mediates the therapeutic effect of on psoriasis by regulating STAT3 phosphorylation to inhibit the IL-23/IL-17A axis.

Objectives: To explore the active components that mediate the therapeutic effect of on psoriasis and their therapeutic mechanisms.

Methods: TCMSP, TCMIP, PharmMapper, Swiss Target Prediction, GeneCards, OMIM and TTD databases were searched for the compounds in and their targets and the disease targets of psoriasis. A drug-active component-target network and the protein-protein interaction network were constructed, and DAVID database was used for pathway enrichment analysis.

Impact of gut microbial diversity on egg production performance in chickens.

Unlabelled: Chickens are one of the most economically important poultry species, and their egg-laying performance is a crucial economic trait. The intestinal microbiome plays a significant role in the egg-laying performance. To clarify the diversity of chicken intestinal microbiota and its connection to egg-laying performance, this study utilized 16S rRNA sequencing technology to characterize the intestinal microbiomes of 101 chickens from 13 breeds with varying levels of egg production.

[Mechanism of action of Zhengqing Fengtongning Sustained-release Tablets for treatment of knee osteoarthritis based on metabolomics and intestinal flora].

In order to elucidate the therapeutic effect and mechanism of action of Zhengqing Fengtongning Sustained-release Tablets on knee osteoarthritis, this study created a knee osteoarthritis model using 0.2 mL 40 g·L~(-1) papain and randomly divided the rats into the model group, high-dose and low-dose groups of Zhengqing Fengtongning Sustained-release Tablets, and celecoxib group. All groups were given the drug for four weeks, with the diameter of their knee joint being measured during this period.

Methionine thioether reduces the content of 4-hydroxy-2-nonenal in high-temperature soybean oil by preventing the radical chain reaction.

This study investigated how methionine (Met) reduced 4-hydroxy-2-nonenal (4-HNE) generation during the heating of soybean oil. The results showed that Met at 5 mM, 10 mM, 15 mM, 20 mM and 30 mM reduced the 4-HNE content by 0.67 %, 58.

The complete mitochondrial genome of (Hymenoptera: Figitidae).

The complete mitochondrial genome of Chen, 2023 has been sequenced and analyzed for the first time. The total length we assembled is 15,448 bp, which comprises 13 PCGs, 22 tRNAs, 2 rRNAs, and a CR. The overall nucleotide composition consists of 41.

A Comprehensive Assessment of the Nutritional Value, Antioxidant Potential, and Genetic Diversity of from Three Different Regions in China.

is one of the largest species of penaeid shrimp. It has a wide distribution of germplasm resources in the South China Sea and the southeastern coastal regions of China, yet its germplasm characteristics remain insufficiently understood. Therefore, we conducted analyses of basic nutritional components, amino acids, fatty acids, antioxidant indices, and genetic diversity in three populations (FmRP, FmSZ, FmSY).

A one-step and solvent-free strategy for high lignin-containing polyurethane elastomers with excellent mechanical and shape memory performance.

Lignin, a renewable and biodegradable polymer, offers a promising alternative to petroleum-based polyols for polyurethane elastomer synthesis. However, its complex structure poses challenges, such as poor dispersibility and reactivity. This study introduces a novel one-step and solvent-free method for synthesizing lignin-containing polyurethane elastomers (SF-LPUes-ONE) with a high lignin substitution rate of at least 30 wt%.

Immune and physiological responses in to ammonia-N stress: a multi-omics approach.

Ammonia-N stress is a significant environmental factor that adversely affects the health and productivity of aquaculture species. This study investigates the effects of ammonia-N stress on the shrimp through a combination of biochemical, histological, transcriptomic, and metabolomic analyses. Shrimp were exposed to ammonia-N stress for 12 and 96 hours, and key markers of oxidative stress, nitrogen metabolism, immune response, and overall health were assessed.

The Cathode-Electrolyte Interface Constructed with Antioxidant Ascorbic Acid Guides LNMO to Achieve Stable Cycling Under High Voltage Conditions.

LiNiMnO (LNMO) is considered one of the most promising cathode materials for high-energy-density lithium-ion batteries (LIBs). However, free-radical-induced carbonate electrolyte decomposition is a key factor hindering the improvement of battery stability. Inspired by the antioxidative properties of ascorbic acid (AA) in scavenging free radicals, the addition of AA during the electrode fabrication process can effectively terminate free radical chain reactions within the cycling of LNMO.

Plasmon-Enhanced Optoelectronic Graded Neurons for Dual-Waveband Image Fusion and Motion Perception.

Motion recognition based on vision detectors requires the synchronous encoding and processing of temporal and spatial information in wide wavebands. Here, the dual-waveband sensitive optoelectronic synapses performing as graded neurons are reported for high-accuracy motion recognition and perception. Wedge-shaped nanostructures are designed and fabricated on molybdenum disulfide (MoS) monolayers, leading to plasmon-enhanced wideband absorption across the visible to near-infrared spectral range.

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer's disease.

JOURNAL/nrgr/04.03/01300535-202510000-00028/figure1/v/2024-11-26T163120Z/r/image-tiff Alzheimer's disease not only affects the brain, but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota. The aim of this study was to investigate systemic changes that occur in Alzheimer's disease, in particular the association between changes in peripheral organ metabolism, changes in gut microbial composition, and Alzheimer's disease development.

Weakly supervised chest X-ray abnormality localization with non-linear modulation and foreground control.

Chest X-ray is widely used to diagnose lung diseases. Due to the demand for accelerating analysis and interpretation to reduce the workload of radiologists, there has been a growing interest in building automated systems of chest X-ray abnormality localization. However, fully supervised methods usually require well-trained radiologists to annotate bounding boxes manually, which is labor-intensive and time-consuming.

Simulation study of the conformation and dynamics of substrate-supported ring and linear polymer films.

The effects of chain topology on the conformational and dynamic properties of substrate-supported ring and linear polymer films were investigated by molecular dynamics simulations. The study reveals that the adsorbed ring polymer chains exhibit stronger adsorbability but less deformation than the linear ones. This results in a slower desorption of ring chains in a short time.

[Expression of circRNA_051778 in Lung Adenocarcinoma-Associated Malignant and Tuberculous Pleural Effusions and Its Clinical Significance].

Objective: To investigate the expression and clinical significance of circular RNA (circRNA) 051778 in lung adenocarcinoma-malignant pleural effusion (LA-MPE) and tuberculous pleural effusion (TPE).

Methods: This is a cross-sectional study. A total of 212 patients were recruited from the Jiangxi Chest Hospital between October 2018 and September 2019, and their pleural effusion samples and/or plasma samples were collected.

Functional and evolutionary analysis of key enzymes triacylglycerol lipase, glycogen hydrolases in the glycerol and glucose biosynthesis pathway and cellular chaperones for freeze-tolerance of the Rice stem borer, Chilo suppressalis.

Freeze-tolerance is an important physiological trait for terrestrial environmental adaptation and intraspecific geographic-lineage diversification in ectothermic animals, yet there remains a lack of systematic studies on its underlying genetic mechanisms and evolution. To address this problem, we employed the widely distributed rice pest, the Chilo suppressalis, as a model to explore the genetic mechanisms and evolutionary history of freeze-tolerance. First, we systematically characterized its antifreeze mechanisms by performing functional validation of potential key genes in laboratory-reared lines.

A Comprehensive Assessment of Nutritional Value, Antioxidant Potential, and Genetic Diversity in from Three Different Populations.

Due to its high tolerance to salinity and temperature, as well as its strong adaptability, holds an important position in the Chinese aquaculture industry. However, studies on the evaluation of its germplasm resources remain insufficient. This research conducted an in-depth comparative evaluation of from three representative farming regions in China: Sanya, Zhuhai, and Raoping.

Dynamics of Polymer Films on Polymer-Grafted Substrates: A Molecular Dynamics Simulation.

For substrate-supported polymer films, the tails of adsorbed chains are generally assumed to play important roles in the propagation of the substrate's effect inside polymer films. The effects of the grafting density and the rigidity of substrate-grafted polymers, the simplest model for the adsorbed tails, on the diffusivity of film polymers are investigated by performing molecular dynamics simulations. An optimal grafting density σ, around the critical grafting density for the transition from "mushroom" to "brush", is found with the most pronounced suppression of diffusivity on the film polymers; i.

Comparative Study of Nutritional Composition, Physiological Indicators, and Genetic Diversity in from Different Aquaculture Populations.

This study aimed to evaluate the quality and genetic diversity of farmed across three distinct populations from Maoming City (MM), Zhanjiang City (ZJ), and Yangjiang City (YJ) in Guangdong Province. Muscle tissues from were analyzed for phenotypic traits, conventional nutrients, amino acids, and fatty acids, while genetic diversity was assessed using whole genome sequencing techniques. The analysis revealed that the crude protein content in shrimp across the three populations ranged from 20.

Monolithic Integration of Full-Color Microdisplay Screen with Sub-5 µm Quantum-Dot Pixels.

Monolithic integration of color-conversion materials onto blue-backlight micro-light-emitting-diodes (micro-LEDs) has emerged as a promising strategy for achieving full-color microdisplay devices. However, this approach still encounters challenges such as the blue-backlight leakage and the poor fabrication yield rate due to unsatisfied quantum dot (QD) material and fabrication process. Here, the monolithic integration of 0.

Allostatic load in rat model: An efficient tool for evaluating and understanding aging.

Aim: Aging and age-related diseases are an ever-increasing social and public health problem. Allostatic load (AL) shows great potential as an interdisciplinary tool for assessing the aging of human beings but as yet lacks investigation in animal models which is our study focus at.

Methods: Here a continuous study of AL was conducted on naturally aging rats.

Effect of amino acids on the formation and distribution of volatile aldehydes in high oleic sunflower oil during frying.

This research aims to assess the effect of amino acids as lipid antioxidants in reducing the formation of volatile aldehydes in frying oil. Methionine, histidine, and glycine at concentrations of 2.5, 5, and 10 mM were added to high oleic sunflower oil (HOSO) to investigate their effects on the distribution and formation of saturated, monounsaturated, and polyunsaturated volatile aldehydes.

A novel chlorin derivative Shengtaibufen (STBF) mediated photodynamic therapy combined with iodophor for the treatment of chronic superficial leg wounds infected with methicillin-resistant Staphylococcus aureus: A retrospective clinical study.

Objective: Chronic wounds are costly and difficult to treat, resulting in morbidity and even mortality in some cases due to a high methicillin-resistant Staphylococcus aureus (MRSA) burden contributing to chronicity. We aimed to observe the antimicrobial activity and healing-promoting effect of a novel photosensitizer Shengtaibufen (STBF)-mediated antibacterial photodynamic therapy (PDT) on MRSA-infected chronic leg ulcers.

Patients And Methods: This was a retrospective, comparative, single-center clinical study.

A novel strategy for recovery of heavy metals and synthesis of Co-rich alloy from the alkali-treated tungsten residue using photovoltaic silicon kerf waste.

The treatment of spent cemented carbides using the conventional alkali-acid leaching process results in the generation of hazardous solid waste tungsten leaching residue. This study proposed an alternative process using the alkali-treated tungsten leaching residue (AW-residue) without the acid leaching step, preserving Co in the residue. By using photovoltaic silicon kerf waste (SKW) as a reducing agent, heavy metals (Co, Ni, W, Nb, and Ta) were efficiently extracted from AW-residue and a Co-rich alloy was obtained.

Variation of the Tegmen and Cercus in (Orthoptera: Acrididae: Melanoplinae) with Proposal of a New Synonym.

Intraspecific variation is ubiquitous from individual traits to population level and plays an important role in a variety of fields. However, it is often ignored by systematists and comparative evolutionary biologists. In view of the limited knowledge of intraspecific variation, morphology-based identification has hindered the recognition of species borders and led to a great number of problems in the field of taxonomy and systematics.

Effects of Different Salinity Stress on the Transcriptomic Responses of Freshwater Crayfish (, Girard, 1852).

Salinization of freshwater ecosystems is a pressing global issue. Changes in salinity can exert severe pressure on aquatic animals and jeopardize their survival. is a valuable freshwater aquaculture species that exhibits some degree of salinity tolerance, making it an excellent research model for freshwater aquaculture species facing salinity stress.