Predictive efficacy of machine-learning algorithms on intrahepatic cholestasis of pregnancy based on clinical and laboratory indicators.

Objectives: Intrahepatic cholestasis of pregnancy (ICP), a condition exclusive to pregnancy, necessitates prompt identification and intervention to improve the perinatal outcomes. This study aims to develop suitable machine-learning models for predicting ICP based on clinical and laboratory indicators.

Methods: This study retrospectively analyzed data from 1092 pregnant women, with 537 diagnosed with ICP and 555 healthy cases as a control.

Opening SCID newborn screening for novel exon genetic variants through whole-exome sequencing in China.

Background: Severe combined immunodeficiency (SCID) is the most fatal form of inherited primary immunodeficiency disease. Known molecular defect mutations occur in most children with SCID.

Methods: Herein, we report Adenosine Deaminase-SCID (ADA-SCID) using whole-exome sequencing (WES), explore exome mutational landscape and significance for 17 SCID samples, and verify the mutated exon genes using the Gene Expression Omnibus (GEO) datasets.

Integrating metagenomics and metabolomics to study the response of microbiota in black soil degradation.

As the largest commercial food production base and ecological security barrier, land degradation in black soil areas seriously threatens the global food supply and natural ecosystems. Therefore, determining the response of soil microbiota is crucial to restoring degraded soils. This study combined metagenomics and metabolomics to investigate the effect of different degrees of soil degradation on microbial community composition and metabolic function in black soils.

Application and Clinical Analysis of Remote Fetal Heart Rate Monitoring Platform in Continuous Fetal Heart Rate Monitoring Images.

Fetal heart sound is an important part of fetal monitoring and has attracted extensive research and attention from scholars at home and abroad in recent years. The fetal heart rate, extracted from the fetal heart sound signal, is one of the important indicators that reflect the health of the fetus in the womb. In this study, a maternal-fetal Holter monitor based on f ECG technology was used to collect maternal heart rate, fetal heart rate, and uterine contractions signals, isolate the fetal heart rate, and design an algorithm to extract the fetal heart rate baseline, acceleration, variation, wake-up cycle, and nonlinear parameters.

[Introduction of IHE Laboratory Technical Framework].

This paper introduces the purpose, integration profile of workflow, integration profile of content of IHE Laboratory Technical Framework and the dependency on IT Infrastructure Technical Framework. And the domestic situation of LIS and HIS integration is analyzed briefly too.

[A study on the LIS and HIS integration].

The development of hospital business demands the integration of information systems. After studying the relative technologies for system connection,system integration and different modes of connecting system, we put forward a protocol to integrate the existing laboratory information system( LIS) and hospital information system(HIS). It introduces the multi-tier distributed technical methods for improving the client/server applications; it ascertains the units and transactions participating in workflow integration by referencing the IHE( Integrating the Healthcare Enterprises) Laboratory Technology Framework; it implements information exchange by Health Level 7(HL7) standards; and it can conserve previous investment and avoid some problems of security, maintenance and realtime process without the risk of massively updating system.

[Design of a controlling switch set based on RS-232].

As a common computer keyboard and a mouse can't meet the requirements of some special occasions, this paper introduces the design of a controlling switch set based on RS-232 for capturing the image at the medical image workstation. Its working principles, circuit, assembly together with its associated software controller are given in detail. The control switch set features easy manufacturing, low cost and a good reliability.