Development and Validation of a Diagnostic Model for Stanford Type B Aortic Dissection Based on Proteomic Profiling.

Purpose: Stanford Type B Aortic Dissection (TBAD), a critical aortic disease, has exhibited stable mortality rates over the past decade. However, diagnostic approaches for TBAD during routine health check-ups are currently lacking. This study focused on developing a model to improve the diagnosis in a population.

Erratum: Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells: Erratum.

[This corrects the article DOI: 10.7150/thno.61178.

A novel method for effective solidifying chromium and preparing crude stainless steel from multi-metallic electroplating sludge.

Electroplating sludge (ES) is a globally prevalent hazardous waste that primarily contains Cr, Cu, Ni, and Fe. However, the residual Cr phases within the slag potentially poses an environmental risk in current vitrification. A novel method for effective recovering and solidifying Cr in ES is proposed in this work.

Red Room-Temperature Phosphorescence Supramolecular Assemblies Based on Cucurbit[7]uril: Reversible Temperature Stimulation Response and Cell-Specific Silver Ion Imaging.

Solid-state materials with efficient room-temperature phosphorescence (RTP) emission have been widely used in materials science, and organic RTP-emitting systems with heavy-metal doping in aqueous solutions have attracted much attention in recent years. A novel supramolecular interaction was induced by host-guest assembly using cucurbit[7]uril (Q[7]) as the host and brominated naphthalimide phosphor as the guest. This interaction was further enhanced through synergistic chelation stimulated by analytical silver ion complexation.

Co-pyrolysis of sewage sludge and waste tobacco stem: Gas products analysis, pyrolysis kinetics, artificial neural network modeling, and synergistic effects.

This research comprehensively investigates the co-pyrolysis of sewage sludge (SS) and waste tobacco stem (WTS). Various SS and WTS ratios (1:0, 0.75:0.

Sertoli cell-derived extracellular vesicles traverse the blood-testis barrier and deliver miR-24-3p inhibitor into germ cells improving sperm mobility.

Asthenozoospermia, characterized by poor sperm motility, is a common cause of male infertility. Improving energy metabolism and alleviating oxidative stress through drug regimens are potential therapeutic strategies. In this study, we observed upregulated miR-24-3p levels in asthenozoospermia spermatozoa, contributing to energy metabolism disorder and oxidative stress by reducing GSK3β expression.

A multifunctional supramolecular assembly based on cucurbit[7]uril: White light material and Fe(CN) detection.

White light emitting materials have broad application prospects in fields such as displays, lighting devices, etc., but developing such materials faces considerable challenges. In this study, 1,3,5-tris[4-(pyridine-4-butyl)phenyl]benzene derivative (BTPY) was synthesized and a supramolecular assembly with AIE properties named BTPY@Q[7] was prepared with cucurbit[7]uril (Q[7]).

A novel portable smart phone sensing platform based on a supramolecular fluorescence probe for quick visual quantitative detection of picric acid.

Picric acid (PA) is a lethal explosive substance that is easily soluble in water and harmful to the environment. Here, a supramolecular polymer material BTPY@Q[8] with aggregation induced emission (AIE) was prepared by supramolecular self-assembly of cucurbit uril (Q[8]) and 1,3,5-tris[4-(pyridin-4-yl) phenyl] benzene derivative (BTPY), which exhibited aggregation-induced fluorescence enhancement. To this supramolecular self-assembly, the addition of a number of nitrophenols was found to have no obvious effect on the fluorescence, however on addition of PA, the fluorescence intensity underwent a dramatic quench.

Supramolecular Room-Temperature Phosphorescent Hydrogel Based on Hexamethyl Cucurbit[5]uril for Cell Imaging.

The host-guest interaction between hexamethyl cucurbit[5]uril (HmeQ[5]) and 1,4-diaminobenzene (DB) was investigated, and a new low-molecular-weight supramolecular gel was prepared by a simple heating/mixing cooling method. The structure and properties of the supramolecular gel were characterized. Results revealed that DB molecules did not enter the cavity of HmeQ[5] and that hydrogen bonding between the carbonyl group at the HmeQ[5] port and the DB amino groups, together with dipole-dipole interactions and outer wall interactions, were the main driving forces for the formation of the supramolecular gel.

Thermogravimetric pyrolysis kinetics study of tobacco stem via multicomponent kinetic modeling, Asym2sig deconvolution and combined kinetics.

Tobacco stems (TS) are tobacco residues produced, whereby the assessment of the pyrolysis kinetics of TS is critical to realize high-value utilization of agricultural residues. Firstly, a thermogravimetric analyzer was employed to perform the non-isothermal pyrolysis of TS at various heating rates. Then, the deconvolution function by Asym2sig showed that the pyrolysis of TS can be accurately modeled for three parallel decomposition fractions.

Lab-on-a-Molecule Probe: Multitarget Detection of Five Aromatic Pesticides Using a Supramolecular Probe under Single Wavelength Excitation.

In order to prevent and control the effects of pesticide residues on human health and the ecological environment, the rapid, highly sensitive, and selective detection of multiple pesticide residues has become an urgent problem to be solved. Herein, a lab-on-a-molecule probe based on a host-guest complex (ThT@Q[8] probe) has been developed to simultaneously analyze multiple aromatic pesticides under single wavelength excitation, such as fuberidazole, thiabendazole, carbendazim, thidiazuron, and tricyclazole. The fluorescence titration spectra of the ThT@Q[8] probe with the five pesticides mentioned above showed that the fluorescence intensity exhibited a good linear correlation with the pesticide concentration and the limit of detection was as low as 10 M.

An all-in-one strategy for resource recovery and immobilization of arsenic from arsenic-bearing gypsum sludge.

Arsenic (As)-bearing gypsum sludge, one of the most prominent hazardous wastes, has created a myriad of critical problems in human health, waters, soils, and sediments at the global scale. Unfortunately, the reclamation and disposal of As-bearing gypsum sludge have been rarely investigated. This paper aims to explore a novel technology for simultaneous value-added utilization and harmless exploitation of As-bearing gypsum sludge.

Advances in the functional roles of N6-methyladenosine modification in cancer progression: mechanisms and clinical implications.

N-methyladenosine (mA), the methylation targeting the N position of adenosine, is the most common internal modification of mRNA in eukaryotes. Considering the roles of mA in regulating gene expression, the investigation of mA roles in the biological processes including cell renewal, differentiation, apoptosis, and invasion of cancer cells has become a hot research topic. There are three kinds of protein involved in mA regulation.

Investigation of non-isothermal pyrolysis kinetics of waste industrial hemp stem by three-parallel-reaction model.

The evaluation of pyrolysis kinetics for waste industrial hemp stem (IHS) is essential to achieve the high-value utilization of agricultural waste. In present study, firstly, non-isothermal pyrolysis experiments of IHS were performed at different heating rates using a thermogravimetric analyzer. Then, the kinetic triplets (apparent activation energy, pre-exponential factor, and reaction mechanism) of the three pseudo components for IHS (hemicellulose, cellulose, and lignin) were determined by a three-parallel-reaction model.

Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells.

: Since primary prostate cancer (PCa) can advance to the life-threatening metastatic PCa, exploring the molecular mechanisms underlying PCa metastasis is crucial for developing the novel targeted preventive strategies for decreasing the mortality of PCa. RNA N-methyladenosine (mA) is an emerging regulatory mechanism for gene expression and its specific roles in PCa progression remains elusive. Western blotting, quantitative real-time PCR and immunohistochemical analyses were used to detect target gene expression in PCa cells and prostate tissues from patients.

Altered corticostriatal synchronization associated with compulsive-like behavior in APP/PS1 mice.

Mild behavioral impairment (MBI), which can include compulsive behavior, is an early sign of Alzheimer's disease (AD), but its underlying neural mechanisms remain unclear. Here, we show that 3-5-month-old APP/PS1 mice display obsessive-compulsive disorder (OCD)-like behavior. The number of parvalbumin-positive (PV) interneurons and level of high gamma (γ) oscillation are significantly decreased in the striatum of AD mice.

Co-treatment of electroplating sludge, copper slag, and spent cathode carbon for recovering and solidifying heavy metals.

Electroplating sludge, a hazardous solid waste product of the electroplating industry, presents a serious environmental pollution risk. In this study, an environmentally friendly process for solidifying and recovering heavy metals from electroplating sludge using copper slag and spent cathode carbon is proposed. Combining the results of toxicity characteristic leaching procedure tests, thermodynamic analysis, chemical analysis, X-ray diffraction analysis, and electron probe microanalysis, the Cr, Ni, Cu, Fe, and F transformation mechanisms were first probed during vitrification.

Pyrolysis/gasification of pine sawdust biomass briquettes under carbon dioxide atmosphere: Study on carbon dioxide reduction (utilization) and biochar briquettes physicochemical properties.

In this paper, the effects of temperature and CO content on CO reduction (utilization) efficiency and physicochemical properties of pyrolysis/gasification biochar briquettes were investigated. The CO reduction (utilization) efficiency (CRE) reached the peak value of 74.9% in a 10% CO/90% N atmosphere at 600 °C.

Smelting reduction and kinetics analysis of magnetic iron in copper slag using waste cooking oil.

To improve the recovery of copper, the viscosity of copper molten slag is decreased by the reduction of magnetic iron, which, in turn, accelerates the settling and separation of copper droplets from the slag. A new technology is proposed in which waste cooking oil is used as a reductant to reduce magnetic iron in the copper smelting slag and consequently reduce carbon emissions in the copper smelting process. A kinetic model of the reduction of magnetic iron in copper slag by waste cooking oil was built using experimental data, and the accuracy of the model was verified.