A sensitive compound was successfully obtained by coating polyaniline (PANI) on the surface of composite nanoparticles consisting of Au-loaded tin dioxide, named as PANI-Au-SnO, using an polymerization method. NH sensors in thin-film and fiber-shaped forms were prepared by inkjet printing and impregnation methods, respectively, based on PANI-Au-SnO. The response characteristics of these NH sensors developed from composite sensitive materials were investigated in detail.
View Article and Find Full Text PDFMicromachines (Basel)
October 2024
Background: Studies have shown that oral oxycontin tablets can be used for opioid titration. The European Society for Medical Oncology (ESMO) guidelines for adult cancer pain recommend opioid titration through the parenteral route, usually the intravenous or subcutaneous route. Patient-controlled subcutaneous analgesia (PCSA) with hydromorphone needs further evaluation for opioid titration.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
June 2024
The investigation of the interactions between cells and drugs forms a crucial aspect of biological and clinical medical studies. Generally, single-cell or local-cellular studies require a microscopic imaging system with high magnifications, which suffers from low detection throughputs and poor time responses. The study presented in this paper combined SPR and fluorescence to achieve cell localization, real-time monitoring of cell images and quantitative analysis of drugs.
View Article and Find Full Text PDFIEEE Trans Biomed Circuits Syst
February 2024
Deep learning (DL) has been used for electromyographic (EMG) signal recognition and achieved high accuracy for multiple classification tasks. However, implementation in resource-constrained prostheses and human-computer interaction devices remains challenging. To overcome these problems, this paper implemented a low-power system for EMG gesture and force level recognition using Zynq architecture.
View Article and Find Full Text PDFInitially diagnosed malignant pleural effusion (MPE) has different systematic treatments, and defining the best drainage regimen according to the responsiveness of MPE to different systematic treatments is important. This study compared the efficacy of hyperthermic intrathoracic chemotherapy (HITHOC) and pleural catheter drainage (IPCD) for initially diagnosed lung cancer with symptomatic MPE. We retrospectively reviewed the medical records of initially diagnosed lung cancer patients with symptomatic MPE between January 2018 and May 2022.
View Article and Find Full Text PDFHydrogen sulfide (HS) detection remains a significant concern and the sensitivity, selectivity, and detection limit must be balanced at low temperatures. Herein, we utilized a facile solvothermal method to prepare Cu-doped SnO/rGO nanocomposites that have emerged as promising candidate materials for HS sensors. Characterization of the Cu-SnO/rGO was carried out to determine its surface morphology, chemical composition, and crystal defects.
View Article and Find Full Text PDFFlexible wearable devices have been widely used in biomedical applications, the Internet of Things, and other fields, attracting the attention of many researchers. The physiological and biochemical information on the human body reflects various health states, providing essential data for human health examination and personalized medical treatment. Meanwhile, physiological and biochemical information reveals the moving state and position of the human body, and it is the data basis for realizing human-computer interactions.
View Article and Find Full Text PDFHS is a poisonous gas that is widespread in nature and human activities. Its rapid and sensitive detection is essential to prevent it from damaging health. Herein, we report Pd- and Pt-bimetallic-nanoparticle-doped InO hollow microspheres that are synthesized using solvothermal and in situ reduction methods for HS detection.
View Article and Find Full Text PDFPressure sensors with high sensitivity, a wide linear range, and a quick response time are critical for building an intelligent disease diagnosis system that directly detects and recognizes pulse signals for medical and health applications. However, conventional pressure sensors have limited sensitivity and nonideal response ranges. We proposed a multichannel flexible pulse perception array based on polyimide/multiwalled carbon nanotube-polydimethylsiloxane nanocomposite/polyimide (PI/MPN/PI) sandwich-structure pressure sensor that can be applied for remote disease diagnosis.
View Article and Find Full Text PDFBackground: Osimertinib is a recently approved third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR-T790M resistance mutations. The aim of the present meta-analysis was to investigate the efficacy and safety of osimertinib for patients with EGFR-mutated non-small-cell lung cancer (NSCLC).
Materials And Methods: Databases were searched for randomized controlled studies that reported the efficacy and safety of osimertinib versus other treatments (chemotherapy, other EGFR-TKIs, etc.
In this work, SnO nanoflowers were prepared by a simple one-step hydrothermal process. The morphology and structure of SnO nanoflowers were characterized by SEM, TEM, Raman spectroscopy, and XRD, which demonstrated the good crystallinity of the SnO tetrahedron structure of the as-synthesized materials. In addition, the sensing properties of SnO nanoflowers were studied in detail.
View Article and Find Full Text PDFSome human exhaled volatile organic compounds (VOCs) can be employed to diagnose related human endogenous diseases as characteristic biomarkers, which is expected to be applied to rapid screening and grading because of their non-invasive and cost-effective advantages. In this study, we developed a compact gas chromatography (GC) platform mainly composed of an integrated silicon-based micro-column chip using micro-electromechanical system techniques and a miniaturized metal oxide semiconductor gas detector. In addition, the sampling/switching valve with related components and embedded microcontrollers was used for airflow control.
View Article and Find Full Text PDFInt J Environ Res Public Health
June 2022
In modern societies, the air quality in vehicles has received extensive attention because a lot of time is spent within the indoor air compartment of vehicles. In order to further understand the level of air quality under different conditions in new vehicles, the vehicle interior air quality (VIAQ) in new vehicles with three different brands was investigated under static and driving conditions, respectively. Air sampling and analysis are conducted under the requirement of HJ/T 400-2007.
View Article and Find Full Text PDFHydrogen (H) sensors are of great significance in hydrogen energy development and hydrogen safety monitoring. However, achieving fast and effective detection of low concentrations of hydrogen is a key problem to be solved in hydrogen sensing. In this work, we combined the excellent gas sensing properties of tin(IV) oxide (SnO) and zinc oxide (ZnO) with the outstanding electrical properties of reduced graphene oxide (rGO) and prepared palladium (Pd)-doped rGO/ZnO-SnO nanocomposites by a hydrothermal method.
View Article and Find Full Text PDFAfrican swine fever (ASF) is a swine disease with a very high fatality rate caused by a complex double-stranded DNA virus. The fluorescence PCR detection method is widely used for virus nucleic acid detection. Surface plasmon resonance (SPR) is a label-free and real-time detection method, unlike the fluorescence PCR detection method.
View Article and Find Full Text PDFBackground: Multiple myeloma (MM) is considered one of the prevalent malignant plasma cell diseases affecting people. In essence, maintenance treatment is valuable for prolonging the survival time of patients experiencing MM. The majority of the currently used treatment protocols for MM are founded on a combination of chemotherapy and immunomodulatory drugs, of which immunomodulatory drugs seems to be one of the most active drugs.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
August 2022
The cuff-less blood pressure (BP) monitoring method based on photoplethysmo- gram (PPG) makes it possible for long-term BP monitoring to prevent and treat cardiovascular and cerebrovascular events. In this paper, a portable BP prediction system based on feature combination and artificial neural network (ANN) is implemented. The robustness of the model is improved from three aspects.
View Article and Find Full Text PDFMicromachines (Basel)
February 2022
Air microfluidic circuits have been widely concerned in the separation of atmospheric particulate matter, especially for portable particulate matter separation detection devices. Currently, no systematic approach for the design and optimization of an air-microfluidic system for PM separation has been reported in the literature. In this paper, a two-stage air microfluidic circuit is designed.
View Article and Find Full Text PDFIntrahepatic cholangiocarcinoma (iCCA) derived from epithelial cells of bile ducts is highly aggressive tumor. Hesperidin extracted from citrus fruits is a promising antitumor compound. The purpose of this study is to explore molecular mechanism by which hesperidin affects cholangiocarcinoma progression.
View Article and Find Full Text PDFBackground: Targeted cancer therapy has shed light on the treatment of tumor, especially for patients with non-small cell lung cancer. However, only a limited portion of NSCLC patients carrying specific mutations showed an ideal drug response. In addition, DNA methylation status showed a great potential for cancer detection and prognosis prediction.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) have ushered in a new era of cancer therapy; however, ICIs are only effective in selective patients. The efficacy of ICIs is closely related to the tumor microenvironment. Fever for a long time was thought to directly regulate the immune response, and artificial "fever" from hyperthermia modulates the tumor immune microenvironment by providing danger signals with heat shock proteins (HSPs) as well as subsequent activation of immune systems.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs), which are non-protein-coding transcripts, are emerging as novel biomarkers for cancer diagnosis. Their dysregulation is increasingly recognized to contribute to the development and progression of human cancers, including lung cancer. Linc00485 is a newly discovered cancer-related lncRNA; however, little is known about its role in lung cancer progression.
View Article and Find Full Text PDF