Publications by authors named "JianChu Li"

Background: Inpatients with high risk of venous thromboembolism (VTE) usually face serious threats to their health and economic conditions. Many studies using machine learning (ML) models to predict VTE risk overlook the impact of class-imbalance problem due to the low incidence rate of VTE, resulting in inferior and unstable model performance, which hinders their ability to replace the Padua model, a widely used linear weighted model in clinic. Our study aims to develop a new VTE risk assessment model suitable for Chinese medical inpatients.

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  • A study was conducted to assess the use and effectiveness of ultrasound (US) and computed tomography (CT) in diagnosing acute appendicitis (AA) among radiologists in China.
  • The survey included responses from 141 radiologists and analyzed medical records from over 5,000 patients, highlighting that US is more frequently used than CT for both adults and children.
  • Results showed that US has diagnostic performance comparable to CT, with US being a cost-effective and non-radiative option for AA diagnosis.
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  • Pediatric thyroid nodules have a higher risk of cancer than adult nodules, yet there is no dedicated ultrasound evaluation system for children.
  • This study analyzed ultrasound images of 177 thyroid lesions from kids under 18 to see how well adult-based systems (ACR-TIRADS and C-TIRADS) could identify cancer.
  • Findings showed strong diagnostic ability and agreement for both systems, but they emphasized the need for a more tailored ultrasound evaluation specifically for children’s thyroid nodules.
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  • The study aimed to evaluate the effectiveness of strain elastography (SE) in improving the categorization of ultrasound Breast Imaging Reporting and Data System (BI-RADS) 3 and 4a lesions, potentially reducing unnecessary biopsies.
  • A total of 4,371 patients were analyzed, using various methods to combine BI-RADS with elasticity scores and strain ratios, which showed improved diagnostic performance compared to BI-RADS alone.
  • The findings suggested that downgrading only BI-RADS 4a lesions might be sufficient for maintaining a high diagnostic accuracy, thereby decreasing false-positive rates in breast biopsies.
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Intravenous leiomyomatosis (IVL) is a rare gynecological-related tumor. It can invade and extend in the blood vessel and eventually involve the cardiac cavity or even the pulmonary artery. IVL generally does not adhere to the vein wall and infrequently leads to the manifestation of Budd-Chiari syndrome (BCS).

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Context: Ultrasound (US) is the most economical and widely used method for detecting lesions in parathyroid regions. Identifying typically parathyroid adenomas as hypoechoic nodules with clear margins. However, 10 % of lesions exhibit atypical features, such as the dual concentric sign, and the cognition of them still needs to be improved.

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  • A new noninvasive method using artificial intelligence-assisted ultrasound was developed to identify lymph node (LN) status in breast cancer patients with suspicious axillary lymph nodes (ALN) but negative clinical exams.
  • The study involved 266 patients and utilized a deep learning model, DeepLabV3+, to analyze ultrasound images for predicting ALN metastasis effectively.
  • Results showed the model had a strong accuracy (0.889) and specificity (100%), making it a reliable tool for assessing LN status and aiding in treatment planning for breast cancer patients.
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Background: To investigate whether the intraoperative superb microvascular imaging(SMI) technique helps evaluate lesion boundaries compared with conventional grayscale ultrasound in brain tumor surgery and to explore factors that may be associated with complete radiographic resection.

Methods: This study enrolled 57 consecutive brain tumor patients undergoing surgery. During the operation, B-mode and SMI ultrasound evaluated the boundaries of brain tumors.

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Background: Developmental dysplasia of the hip (DDH) is a common childhood health complaint, whose etiology is multifactorial. The incidence of DDH is variable and higher in Tibet plateau. Here, we collected plasma samples and studied the metabolomics signatures of DDH.

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  • A study explored the use of deep learning (DL) to improve the accuracy of selecting sampling positions in renal artery ultrasound exams, which hasn't been previously researched.
  • The research involved 2004 patients, categorizing their color Doppler sonography images into four groups: abdominal aorta, normal renal artery, renal artery stenosis, and intrarenal interlobular artery.
  • Among seven DL object detection models tested, the Double Head R-CNN model performed the best, achieving high accuracies and suggesting that it could help less experienced physicians make better sampling position choices.
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Venous ultrasound is the primary, widely accepted diagnostic tool to assess deep vein thrombosis (DVT) in the lower extremities. However, other focal lesions in the lower extremities can be identified on ultrasound. The sonographic appearance of these abnormalities may overlap the thrombosis, which included vascular tumors, Baker's cyst, hematoma, cancer thrombosis, and peripheral nerve tumors.

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Objective: This study aimed to investigate the impact of microbubble degradation and flow velocity on Sub-Harmonic Aided Pressure Estimation (SHAPE), and to explore the correlation between subharmonic amplitude and pressure as a single factor.

Methods: We develop an open-loop vascular phantom platform system and utilize a commercial ultrasound machine and microbubbles for subharmonic imaging. Subharmonic amplitude was measured continuously at constant pressure and flow velocity to assess the impact of microbubble degradation.

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Background: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology.

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Purpose: Diagnosing Renal artery stenosis (RAS) presents challenges. This research aimed to develop a deep learning model for the computer-aided diagnosis of RAS, utilizing multimodal fusion technology based on ultrasound scanning images, spectral waveforms, and clinical information.

Methods: A total of 1485 patients received renal artery ultrasonography from Peking Union Medical College Hospital were included and their color doppler sonography (CDS) images were classified according to anatomical site and left-right orientation.

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  • The study aimed to evaluate the effectiveness of ultrasound in diagnosing juxtaglomerular cell tumors (JGCT) by analyzing cases from 15 patients over 15 years.
  • Results showed that while ultrasound detected 11 out of 15 tumors, those missed were generally smaller and less likely to protrude.
  • The research concludes that ultrasound, alongside clinical signs like secondary hypertension, is beneficial for diagnosing this rare tumor, especially in younger women.
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Background: Vascular features are not commonly used to evaluate thyroid nodules by conventional ultrasound due to the low sensitivity. Superb Microvascular Imaging (SMI) is a new ultrasonic Doppler technology that specializes in depicting microvessels and low-speed flow. The objective of this study was to explore the value of microflow features on SMI in differentiating malignant from benign thyroid nodules.

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This study aims to establish precise quality indicators for evaluating and enhancing ultrasound performance, employing a methodology based on a comprehensive review of the literature, expert insights, and practical application experiences. We conducted a thorough review of both the domestic and international literature on ultrasound quality control to identify potential indicators. A dedicated team was formed to oversee the complete indicator development process.

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  • The study aimed to assess how effective ultrasound (US) is for locating ectopic hyperparathyroidism compared to other imaging methods like Tc-sestamibi (Tc-MIBI), 4D-CT, and C-choline PET/CT.
  • Among 79 patients with ectopic hyperparathyroidism, the sensitivity rates for detecting lesions were 75.9% for US, 81.7% for Tc-MIBI, 95.1% for US combined with MIBI, 83.3% for 4D-CT, and a perfect 100% for C-choline PET/CT.
  • The results showed that US is particularly effective for lesions in the neck but less so
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Purpose: Carotid ultrasound allows noninvasive assessment of vascular anatomy and function with real-time display. Based on the transfer learning method, a series of research results have been obtained on the optimal image recognition and analysis of static images. However, for carotid plaque recognition, there are high requirements for self-developed algorithms in real-time ultrasound detection.

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Background: Intravenous leiomyomatosis (IVL) is a rare endocrine-associated tumor with unique characteristics of intravascular invasion. This study aimed to identify reliable biomarkers to supervise the development or recurrence of IVL in the context of predictive, preventive, and personalized medicine (PPPM/3PM).

Methods: A total of 60 cases were recruited to detect differentially expressed proteins (DEPs) in serum samples from IVL patients.

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The aim of this study was to validate the performance of the Ovarian-Adnexal Reporting and Data Systems (O-RADS) series models proposed by the American College of Radiology (ACR) in the preoperative diagnosis of adnexal masses (AMs). Two experienced sonologists examined 218 patients with AMs and gave the assessment results after the examination. Pathological findings were used as a reference standard.

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Background: This study intends to analyze the hemodynamic parameters of the renal artery in patients with Takayasu's arteritis (TAK) to explore the diagnostic efficacy of duplex ultrasonography in assessing the involved renal artery in TAK patients.

Methods: One hundred fifteen TAK patients with 314 renal arteries were retrospectively analyzed, who were admitted to Peking Union Medical College Hospital between 2017 and 2022. These patients underwent both renal artery ultrasonography and angiography within a 4-week period.

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