[Optimization of Dyeing Wastewater Treatment with New Eco-friendly Polysilicate Ferromanganese].

To improve the efficiency of the removal of dye wastewater, a new type of coagulant "polysilicate ferromanganese (PSFM)" has been synthesized using sodium silicate, ferrous sulfate, and potassium permanganate. Three dyes (direct red, disperse blue, and active yellow) were used for the coagulation tests. The effects of the alkalinity and turbidity on the performance of PSFM were studied.

[Adsorption of Tetracycline on Simulated Suspended Particles in Water].

The mechanism of adsorption of a typical antibiotic (tetracycline, TC) on particles in the aquatic environment and the parameters affecting adsorption were investigated. Experiments were conducted to elucidate the effects of pH and various cation species with different concentrations. The results show that the adsorption of TC on particles is rapid during the first four hours in the mixing stage.

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.

Numerous studies have shown that the NALP3 inflammasome plays an important role in various immune and inflammatory diseases. However, whether the NALP3 inflammasome is involved in the pathogenesis of diabetic nephropathy (DN) is unclear. In our study, we confirmed that high glucose (HG) concentrations induced NALP3 inflammasome activation both in vivo and in vitro.

Design, synthesis and structure-activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans.

Background: Strobilurins are one of the most important classes of agricultural fungicides. To discover new strobilurin analogues with broad spectrum and high activity, a series of novel oxime ether strobilurin derivatives containing substituted benzofurans in the side chain were synthesised and bioassayed.

Results: The synthesised compounds were characterised by (1) H NMR, (13) C NMR, MS and HRMS.

Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients.

Background: Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease (CKD) patients are limited. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of hypertension in the non-dialysis CKD patients through a nationwide, multicenter study in China.

Methods: The survey was performed in 61 tertiary hospitals in 31 provinces, municipalities, and autonomous regions in China (except Hong Kong, Macao, and Taiwan).

Rapid dye degradation with reactive oxidants generated by chloride-induced peroxymonosulfate activation.

Transition-metal is known to catalyze peroxymonosulfate (PMS) decomposition to produce sulfate radicals. Here we report reactions between PMS and chloride, without a need of transition metals, also can be used to degrade organic dye pollutant (Rhodamine B, (RhB)). Some important operating parameters, such as dosages of PMS and Cl(-), pH of solution, temperature, ionic strength, and several common cations, were systematically investigated.

High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies.

Objective: Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.

Design And Methods: We conducted a systematic literature search of the PubMed database through April 2012.

[Based on the LS-SVM modeling method determination of soil available N and available K by using near-infrared spectroscopy].

Visible infrared spectroscopy (Vis/SW-NIRS) was investigated in the present study for measurement accuracy of soil properties,namely, available nitrogen(N) and available potassium(K). Three types of pretreatments including standard normal variate (SNV), multiplicative scattering correction (MSC) and Savitzky-Golay smoothing+first derivative were adopted to eliminate the system noises and external disturbances. Then partial least squares (PLS) and least squares-support vector machine (LS-SVM) models analysis were implemented for calibration models.

Tetra-aqua-bis-[4-(1H-imidazol-1-yl-κN(3))benzoato]cobalt(II).

In the title compound, [Co(C(10)H(7)N(2)O(2))(2)(H(2)O)(4)], the Co(II) atom lies on an inversion centre and displays a slightly distorted octa-hedral geometry. The coordination sphere is defined by two mutually trans N atoms from two 4-(imidazol-1-yl)benzoate ligands and the O atoms from four water mol-ecules. The crystal structure is stabilized by O-H⋯O hydrogen bonds.

Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes.

Albumin, which is the most abundant component of urine proteins, exerts injurious effects on renal cells in chronic kidney diseases. However, the toxicity of albumin to podocytes is not well elucidated. Here, we show that a high concentration of albumin triggers intracellular calcium ([Ca(2+)](i)) increase through mechanisms involving the intracellular calcium store release and extracellular calcium influx in conditionally immortalized podocytes.

(5,5'-Dimethyl-2,2'-bipyridine-κN,N')(1-naphthyl-acetato-κO)(1-naphthyl-acetato-κO,O')zinc hemihydrate.

In the title compound, [Zn(C(12)H(9)O(2))(2)(C(12)H(12)N(2))]·0.5H(2)O, the water mol-ecule lies on a twofold rotation axis. The Zn(II) atom is coordinated by three O atoms from two 1-naphthyl-acetate ligands, one monodentate and the other asymmetric bidentate chelate, and two N atoms from a 5,5'-dimethyl-2,2'-bipyridine ligand, giving an irregular environment.

Bis(2,4-dichloro-phen-oxy-acetato-κO,O)(5,5'-dimethyl-2,2'-bipyridine-κN,N')cobalt(II).

In the title compound, [Co(C(8)H(5)Cl(2)O(3))(C(12)H(12)N(2))], the Co(II) atom, lying on a twofold rotation axis, is coordinated by four O atoms from two chelating 2,4-dichloro-phen-oxy-acetate ligands and two N atoms from a 5,5'-dimethyl-2,2'-bipyridine ligand, displaying a distorted octa-hedral geometry. A three-dimensional supra-molecular structure is formed through inter-molecular C-H⋯O hydrogen bonds and π-π stacking inter-actions between the pyridine and benzene rings [centroid-centroid distance = 3.779 (2) Å].

Role of CD2-associated protein in albumin overload-induced apoptosis in podocytes.

Proteinuria is a well-established exacerbating factor of chronic kidney diseases. However, the harmful effects of protein overload on podocytes and the underlying mechanisms are still poorly understood. In the present study, we examined the effects of high concentrations of albumin on podocytes and investigated the role of CD2AP (CD2-associated protein) in albumin overload-induced podocyte apoptosis.

Downregulation of CD2-associated protein impaired the physiological functions of podocytes.

Emerging evidences show that CD2-associated protein (CD2AP) is involved in podocyte injury and the pathogenesis of proteinuria. However, the exact molecular mechanism by which CD2AP exerts its biological function is elusive. We knocked down CD2AP gene by target siRNA in conditionally immortalized mouse podocytes, which showed lowered cell adhesion and spreading ability (P<0.

[Role of CD2-associated protein in podocyte differentiation.].

To study the cellular changes and the potential role of CD2-associated protein (CD2AP) in podocyte differentiation, conditionally immortalized murine podocyte cell line was cultured in RPMI 1640 medium under permissive condition at 33 °C. After transfection with CD2AP small interfering RNA (siRNA) the cells were shifted to non-permissive condition at 37 °C. Simultaneously, untransfected cells were taken as differentiation control.

[Protein kinase C-betaI, betaII in mouse diabetic nephropathy kidney and its relation to nephroprotective actions of the angiotensin receptor blocker telmisartan].

Objective: To investigate the localization and expression of protein kinase C (PKC)-betaI, betaII in diabetic nephropathy (DN) mouse kidney and its relation to angiotensin receptor blocker telmisartan (Micardis).

Methods: Eighteen mice were divided into three groups: normal group, DN group and Micardis-treated group (n = 6, each group). The expression of PKC-betaI, betaII, transforming growth factor- beta 1 (TGF-beta1) and vascular endothelial growth factor (VEGF) in glomeruli was measured by semiquantitative immunofluorescence histochemistry, the localization of PKC-betaI, betaII was detected by confocal immunofluorescence laser scanning microscopy and the expression of PKC-betaI, betaII in renal cortex, outer and inner medulla were evaluated by semiquantitative Western blotting.

Effect of telmisartan on expression of protein kinase C-alpha in kidneys of diabetic mice.

Aim: To investigate the effects of angiotensin receptor blocker (ARB) telmisartan on the expression and distribution of protein kinase C (PKC)-alpha in the kidneys of diabetic mice.

Methods: Diabetic mice were induced with streptozotocin and a group of them were randomly selected for treatment with telmisartan. After 6 weeks, the expression and localization of PKC-alpha in the renal cortex, and the outer and inner medulla were assessed by immunohistochemistry and semiquantitative Western blotting.

Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis.

Aim: To study the potential pathological role of endogenous angiopoietins in daunorubicin-induced progressive glomerulosclerosis in rats.

Methods: Seventy male Wistar rats were allocated randomly into a daunorubicin group (DRB; n=40) or a control group (n=30). The rats in the DRB group were injected with DRB (15 mg/kg), in their tails.

The expression of toll-like receptor 2, 4 of livers in mice with systemic inflammatory response syndrome.

Background: The complicated pathogenesis of systemic inflammatory response syndrome (SIRS) is a hot topic in critical care medicine. In this study we explored the expression of toll-like receptor (TLR) 2, 4 of livers in SIRS mice and evaluated the role of TLR2, 4 in the pathogenesis of SIRS.

Methods: Forty BABL/C mice were randomly divided into 2 groups: control (n=20) and SIRS (n=20).

[Role of connective tissue growth factor in human renal tubular epithelial cell transdifferentiation in vitro].

Objective: To observe the effect of connective tissue growth factor (CTGF) on the transdifferentiation of human renal tubular epithelial cells and to explore the influence of CTGF antisense oligodeoxynucleotide (ASODN) transfection on the transdifferentiation process induced by transforming growth factor-beta1 (TGF-beta1).

Methods: Human renal tubular epithelial cells of the strain HKC were cultured and divided into 3 groups: (1) negative control group, (2) low dose CTGF group, treated with recombinant human CTGF (rhCTGF) with the terminal concentration of 2.5 microg/L, and (3) high dose CTGF group, treated with rhCTGF with the terminal concentration of 5.