Publications by authors named "Jian-qiang Cai"
Article Synopsis
- The study aimed to evaluate the safety and efficacy of using intraoperative electron radiotherapy (IOERT) in conjunction with narrow-margin resection for centrally located hepatocellular carcinoma (CL-HCC) in 37 patients over a 7-year period.
- Results showed promising long-term survival rates, with 1-year, 3-year, and 5-year overall survival rates at 91.39%, 88.34%, and 88.34%, respectively, while most patients did not experience significant complications.
- The findings suggest that a 15 Gy dose of IOERT is both safe and effective, raising the possibility of using this method as a standard treatment for patients with CL-HCC.
Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma.
World J Gastroenterol
December 2021
The low resection and high recurrence rates in hepatocellular carcinoma (HCC) are the major challenges to improving prognosis. Neoadjuvant and conversion therapies are underlying strategies to overcome these challenges. To date, no guideline or consensus has been published on the neoadjuvant and conversion therapies in HCC.
View Article and Find Full Text PDFBackground: The complete resection of primary duodenal adenocarcinoma (PDA) offers a chance for a cure, but the clinical and pathological characteristics of survivors have not been well studied.
Methods: Patients with stage I-III PDA who underwent surgical resection between 2013 and 2018 were identified retrospectively and followed until December 2019. All patients are from the Cancer Hospital Chinese Academy of Medical Sciences.
Several indexes evaluating the lymph node metastasis of pancreatic neuroendocrine tumor (pNET) have been raised. We aimed to compare the prognostic value of the indexes via the analysis of Surveillance, Epidemiology, and End Results (SEER) database.We identified pNETs patients from SEER database (2004-2015).
View Article and Find Full Text PDFObjective: The aim of this study was to determine whether adjuvant chemotherapy (AC) provides a survival benefit in patients with nonmetastatic poorly differentiated colorectal neuroendocrine carcinomas (CRNECs) following resection.
Background: There is little evidence to support the association between use of AC and improved overall survival (OS) in patients with CRNECs.
Methods: Patients with resected non-metastatic CRNECs were identified in the National Cancer Database (2004-2014).
Background: Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS).
Methods: Patients with resected pNETs were identified in the National Cancer Database (2004-2014). The inverse probability of treatment weighting (IPTW) method was used to reduce the selection bias.
Background: Percutaneous radiofrequency ablation (RFA) is used as a first-line treatment for colorectal liver metastases that recur after first liver resection in our institution. We aim to evaluate its therapeutic efficacy compared to repeated surgical resection.
Methods: A retrospective review was performed in 104 patients treated with curative intent for resectable recurrent colorectal liver metastases.
Article Synopsis
- - The study compares traditional hepatectomy classification (minor vs. major resection) with a new complexity classification to predict post-surgery complications for liver resections in patients with hepatocellular carcinoma.
- - Analysis of data from 302 patients showed the complexity classification was better at predicting significant intraoperative issues (like high blood loss and long operation times) and severe postoperative complications than the traditional method.
- - The findings suggest that the complexity classification provides a more accurate assessment of surgical difficulty and associated complications, while the traditional classification is limited mainly to predicting posthepatectomy liver failure.
Article Synopsis
- Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancer cases in China, largely due to widespread chronic hepatitis B infection, making it a major health issue.* -
- The National Health and Family Planning Commission of China released guidelines crafted by over 50 HCC experts, addressing surveillance, diagnosis, staging, and treatment strategies for HCC.* -
- The guidelines include a Chinese staging system and recommendations aimed at optimizing patient outcomes for individuals with HCC in China.*
Article Synopsis
- Systemic inflammation (SI) affects tumor progression and survival in hepatocellular carcinoma (HCC) patients, with certain gene variations (SNPs) in the human leukocyte antigen (HLA) region potentially influencing patient outcomes.
- In a study of 330 HCC patients, specific SNPs (rs3997872, rs7453920, rs7768538) were linked to overall survival, while the rs7453920 genotype was notably associated with the neutrophil/lymphocyte ratio (NLR), a marker for SI.
- The findings suggest that the absence of a specific genetic variant (minor allele A of rs7453920) increases SI and is correlated with poorer overall survival in patients with
Background: The neutrophil to lymphocyte ratio (NLR) is a marker of inflammation and is associated with poor outcomes. We aimed to evaluate the role of the pretreatment NLR in predicting the outcomes after preoperative chemotherapy in patients with colorectal liver metastases (CRLM).
Methods: A retrospective review was performed for 183 patients with CRLM.
Objective: There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Murr (Huaier granule) to address this unmet need.
Design And Results: A total of 1044 patients were randomised in 2:1 ratio to receive either Huaier or no further treatment (controls) for a maximum of 96 weeks.
The aims of this study were to assess early recurrence predictive factors and elucidate the best early recurrence management. 255 patients with colorectal liver metastases (CRLM) who underwent hepatectomy were retrospectively analyzed. A total of 87 patients (34.
View Article and Find Full Text PDFPurpose: We sought to determine the impact of surgical margin status on overall survival (OS) and recurrence pattern stratified by tumor burden.
Materials And Methods: Data were collected from patients undergoing resection for colorectal liver metastases (CRLM). Tumor burden was calculated according to a newly proposed Tumor Burden Score (TBS) system, defined as the distance from the origin on a Cartesian plane that incorporated maximum tumor size and number of liver lesions.
The long-term outcome of 228 patients with colorectal liver metastases (CRLM) who underwent preoperative chemotherapy followed by hepatectomy ± RFA were retrospectively analyzed. Stratified by chemotherapy response, patients were divided into responding (n=129) and non-responding groups (n=99). Patients who underwent hepatectomy-RFA had a greater number of metastases (median of 4 vs.
View Article and Find Full Text PDFBackground: The liver is the most common site for colorectal cancer (CRC) metastases. Their removal is a critical and challenging aspect of CRC treatment. We investigated the prognosis and risk factors of patients with CRC and liver metastases (CRCLM) who underwent simultaneous resections for both lesions.
View Article and Find Full Text PDFBackground: Lymph node status is crucial to determining treatment for early gastric cancer (EGC). We aim to establish a nomogram to predict the possibility of lymph node metastasis (LNM) in EGC patients.
Methods: Medical records of 952 EGC patients with curative resection, from 2002 to 2014, were retrospectively retrieved.
Background: Controversial results about the therapeutic value of radiofrequency ablation (RFA) and liver resection (LR) in the treatment of colorectal cancer liver metastasis (CRCLM) have been reported. Thus, we performed the present meta-analysis to summarize the related clinical evidences.
Methods: A systematic literature search was conducted using PubMed (Medline), EMBASE, Cochrane Library, and Web of Science, for all years up to April 2016.
Purpose: Lactate dehydrogenase (LDH), which was an indirect marker of hypoxia, was a potentially prognostic factor in several malignancies. There is a lack of evidence about the prognostic value of serum LDH level in patients with hepatocellular carcinoma (HCC) receiving sorafenib treatment from hepatitis B virus endemic areas.
Materials And Methods: A total of 119 HBV-related HCC patients treated by sorafenib from a Chinese center were included into the study.
Aim: The prognostic value of the newly raised objective liver function assessment tool, the albumin-bilirubin (ALBI) grade, in patients with hepatocellular carcinoma has not been fully validated. We aimed to compare the performance of ALBI grade with the specific Child-Pugh (C-P) score in predicting prognosis in this study.
Methods: The clinical data of 491 C-P class A patients who underwent liver resection as initial therapy from January 2000 to December 2007 in Cancer Hospital, Chinese Academy of Medical Sciences (Beijing, China) were retrospectively analyzed.
Background: Conflicting results about the prognostic value of surgical margin status in patients with intrahepatic cholangiocarcinoma (ICC) have been reported. We aimed to assess the association between surgical margin status and prognosis in ICC through a meta-analysis.
Materials And Methods: We conducted a literature search of the articles evaluating the prognostic value of surgical margin status in patients with ICC.
The purpose of this study was to evaluate the prognostic value of lymph node ratio (LNR) in patients with gastric cancer liver metastasis (GCLM) who received combined surgical resection. A retrospective analysis of 46 patients from two hospitals was conducted. Patients were dichotomized into two groups (high LNR and low LNR) by the median value of LNR.
View Article and Find Full Text PDFBackground: Conflicting results about the association between expression level of excision repair cross-complementation group 1 (ERCC1) and clinical outcome in patients with colorectal cancer (CRC) receiving chemotherapy have been reported. Thus, we searched the available articles and performed the meta-analysis to elucidate the prognostic role of ERCC1 expression in patients with CRC.
Methods: A thorough literature search using PubMed (Medline), Embase, Cochrane Library, Web of Science databases, and Chinese Science Citation Database was conducted to obtain the relevant studies.
Assessing the prognosis of patients with hepatocellular carcinoma (HCC) by the number and size of tumors is sometimes difficult. The main purpose of the study was to evaluate the prognostic value of total tumor volume (TTV), which combines the two factors, in patients with HCC who underwent liver resection. We retrospectively reviewed 521 HCC patients from January 2001 to December 2008 in our center.
View Article and Find Full Text PDF