Publications by authors named "Jian-lan Li"
Article Synopsis
- A rare case of a 33-year-old man developed pro-B-acute lymphoblastic leukemia (ALL) from myelodysplastic syndrome (MDS) with identified genetic mutation (S1231F) that may influence disease progression but isn't a negative prognostic marker.
- An analysis of 30 MDS patients showed the majority transformed to ALL within a median of 5.5 months, predominantly male with a median age of 56, and types included MDS-excess blasts and MDS-single lineage dysplasia.
- The study revealed a 75% complete remission rate with ALL-directed chemotherapy, yet the transformation was linked to a concerning early death rate of 20% among these patients.
Objective: To explore the changes in expression of WT1 gene and ration of its isomers during phorbol ester (TPA) induced differentiation of leukemia cell line K562 by fluorescence quantitative RT-PCR and analysis the relationship between different isomers and hematogenic cell differentiation.
Methods: The degree of cellular maturation were verified by NBT reduction test and immunophenotyping. Expression of WT1 gene was determined by fluorescence quantitative RT-PCR during differentiation of K562 cell line.