Publications by authors named "Jian-hua Wu"

Purpose: To investigate the changes of root development before and after orthodontic traction of maxillary inverted impacted central incisors using CBCT and Mimics software.

Methods: Ten patients, who had a maxillary inverted impacted central incisor, were treated using a modified movable retractor combined with surgical eruption. Cone-beam computed tomography(CBCT) was taken before and after treatment.

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  • * Mice fed a methionine-choline deficient diet to induce NASH were treated with rifaximin, which significantly reduced liver fat, inflammation, and fibrosis.
  • * Rifaximin was found to change gut microbiota and inhibit the intestinal DCA-Fxr-Hnf1α signaling pathway, suggesting its potential for treating NASH clinically.
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  • This study investigates the impact of dexmedetomidine (DEX) as a local anesthetic adjuvant on postoperative delirium (POD) in elderly patients after elective hip surgery.
  • A total of 120 patients were divided into two groups: one receiving DEX with ropivacaine (Y group) and the other receiving only ropivacaine (R group).
  • Results showed that the Y group had lower rates of POD, required less remedial analgesia, and experienced better postoperative inflammatory markers, although they had a higher incidence of bradycardia compared to the R group.
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Purpose: Our investigation utilized a two-sample Mendelian randomization approach to explore the ambiguous bidirectional relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression, furthering insights from existing observational studies.

Methods: In this study, we conducted a bidirectional Mendelian randomization using genome-wide association studies (GWAS) datasets. We initially analyzed depression data from the Psychiatric Genomics Consortium and the UK Biobank (n = 500,199), alongside COPD data from the FinnGen Consortium (n = 329,552).

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  • - The study focused on the frequency and risk factors of postoperative delirium in elderly patients after hip surgery, aiming to identify ways to prevent this condition.
  • - Out of 97 patients analyzed, 32 (32.9%) experienced delirium post-surgery, with contributing factors including age, height, gender, and preoperative health indicators.
  • - A significant finding was that the risk of delirium increased by 12% for every additional 10 years in patient age, and a history of delirium in the recovery unit was a strong predictor of developing postoperative delirium.
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Objective: This study aimed to evaluate the effects on the dislocation and misalignment of the cuffed end of a double-lumen endobronchial tube (DLT) when a patient moves from a horizontal to a lateral position without fixation.

Methods: A total of 148 patients who had undergone video-assisted thoracoscope surgery were enrolled and randomly divided into two groups: a group in which the periportal end of the DLT was fixed with tape (group I;  = 74) and a group in which the periportal end of the DLT remained unfixed (group II;  = 74). Both groups were given an intravenous induction for double-lumen endobronchial intubation and then moved from a horizontal position to a lateral position, after which the alignment of the bronchial cuffed end of the DLT was assessed using a fiberoptic bronchoscope.

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Objective: To evaluate the effect of the individualized positive end-expiratory pressure (PEEP) lung protection ventilation strategy by combining driving pressure (ΔP) and pulmonary ultrasound (LUS)-based titration on lung function and postoperative cognitive function in patients with chronic obstructive pulmonary disease (COPD) during laparoscopic surgery.

Methods: A total of 108 patients with COPD undergoing laparoscopic gastrointestinal surgery under general anesthesia were included in this study. They were randomly divided into three groups (n = 36): traditional volume ventilation group (Group C), fixed PEEP 5 cmHO group (Group P), and ΔP combined with LUS-based PEEP titration in the resuscitation room group (Group T).

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Background: Warts are very common in military personnel, either at war or during peace times. However, little is known about the prevalence and natural course of warts in military recruits in China.

Objective: To investigate the prevalence and natural course of warts in Chinese military recruits.

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Background: Lung cancer is the most common cancer-related death worldwide. In 2022, the number of daily deaths of lung cancer was estimated to reach around 350 in the United States. Lung adenocarcinoma is the main subtype of lung cancer and patients with malignant pleural effusion (MPE) suffer from poor prognosis.

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  • The study focuses on improving the pre-operative differentiation between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) using a new deep learning model called CSAM-Net, as current imaging methods are inadequate.
  • Researchers analyzed CT images from 395 HCC and 99 ICC patients and developed the CSAM-Net, which utilizes channel and spatial attention mechanisms for better accuracy.
  • The CSAM-Net model demonstrated significantly higher accuracy (AUC values around 0.987 for training) in distinguishing between HCC and ICC compared to conventional models, suggesting it could be a highly effective non-invasive diagnostic tool for liver cancers.
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Objective: Growth arrest-specific protein 6 (Gas6) may harbor protective effects in acute brain injury. This study was designed to determine the relation of serum Gas6 levels to severity and prognosis after traumatic brain injury (TBI).

Methods: In this prospective cohort study of 114 controls and 114 patients with severe TBI, multivariate analysis was used to assess relationships between serum Gas6 levels, Glasgow coma scale (GCS) score, Rotterdam computed tomography (CT) score, postinjury 180-day mortality, overall survival and poor prognosis (Extended Glasgow outcome scale score 1-4).

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Background: Bushen Jianpi formula (BSJPF, also known as Lingmao formula) is a traditional Chinese medicine for chronic hepatitis B (CHB). The previous study has suggested that the treatment combination of BSJPF and entecavir (ETV) can achieve a significant loss of hepatitis B e antigen (HBeAg) and a significant decrease in serum level of hepatitis B virus (HBV) DNA in HBeAg-positive CHB patients with mildly elevated alanine aminotransferase.

Objective: This study aimed to evaluate the efficacy and safety of BSJPF combined with ETV for treating HBeAg-negative CHB patients.

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(Boraginaceae) is an annual or biannual herb widely distributed in temperate Asia and East Europe. The complete chloroplast genome of was sequenced by high-throughput technologies and assembled for the first time. The complete chloroplast genome of was 147,508 bp in length with a GC content of 37.

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Objective: To evaluate the effects of doxofylline on inflammatory responses and oxidative stress during mechanical ventilation in rats with chronic obstructive pulmonary disease (COPD).

Methods: Eight-week-old male Sprague Dawley rats were selected, and the COPD rat model was constructed. The rats were randomly divided into a model group (group M), a model + normal saline group (group N), a doxofylline group (group D), and a control group fed with conventional chow and given normal oxygen supply (group C) (n = 12 in each group).

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Background: Accumulating studies have suggested the airway microbiota in lung cancer patients is significantly different from that of healthy controls. However, little is known about the relationship between airway microbiota and important clinical parameters of lung cancer. In this study, we aimed to explore the association between sputum microbiota and lung cancer stage, lymph node metastasis, intrathoracic metastasis, and epidermal growth factor receptor (EGFR) gene mutation.

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Materials And Methods: This review is a collection of all possible studies on AR, published in scientific journals, papers, and books. Using the papers related to , such as ScienceDirect, Wiley Online Library, Springer Link, Web of Science, CNKI, and WanFang Database. In this paper, the traditional uses, botany, phytochemistry, pharmacology, and toxicology of AR were reviewed.

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Objective: To evaluate the effect of doxofylline on reducing the inflammatory response in mechanically ventilated rats with chronic obstructive pulmonary disease (COPD).

Methods: A total of 40 eight-week-old male Sprague Dawley rats were randomly divided into four groups of 10 rats each: a control group (group C), a model group (group M), a model + natural saline group (group N), and a doxofylline group (group D). Then mechanical ventilation, drug intervention, and the extraction of the experimental material were performed in each group.

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Purpose: To investigate the clinical outcomes, including survival and periapical healing rates and failure causes, of root canal treatment for patients with periapical lesion.

Methods: A retrospective cohort study was conducted which enrolled patients admitted for the evaluation and management of periapical lesion with root canal treatment. The primary predictor variables were difficulty assessment of root canal therapy (DARCT),which was divided into lower(DARCT =3-4), medium (DARCT =5-7) and higher (DARCT =8-9) difficulty root canal, in terms of canal length, curvature and calcification.

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Background: Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway.

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  • Single-crystal LiNiCoMnO cathode materials prevent the intergranular cracks that often occur in polycrystalline counterparts but still face surface degradation at high cutoff voltages (over 4.5 V).
  • Researchers created single-crystal LiNiCoMnO cathodes and applied a thin Li-Si-O coating, which significantly improved their performance at higher voltages.
  • The coated cathodes showed a capacity retention of 90.6% after 100 cycles compared to only 68.0% for the uncoated version, indicating that the coating helps maintain stability and extend the life of the electrode.
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4-chlorophenol (4-CP) could be rapidly mineralized by using Fenton reaction. However, massive iron sludge will be generated because of the excessive consumption of iron salt and poor recycling of Fe back to Fe. In this paper, by introducing hydrogen gas and solid catalyst Pd/NH-MIL-101(Cr) to classic Fenton reactor, the novel system named MHACF-NH-MIL-101(Cr) was constructed.

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Ethnopharmacological Relevance: Malignant ascites (MA) effusion is mainly caused by hepatocellular, ovarian, and breast cancer etc. It has been reported that Euphorbia kansui (EK), the root of Euphorbia kansui S.L.

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Background: No guideline recommends antiviral therapy for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus (HBV) DNA viral load.

Aim: To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV infection.

Methods: In total, 395 patients (30-65 years old) with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 wk.

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This research is to establish an HPLC method for determination of geniposidic acid, genipin-1-β-D-gentiobioside, geniposide, p-trans-coumaroylgenipin gentiobioside, chlorogenic acid, crocin-Ⅰ, crocin-Ⅱ and crocin-Ⅲ in Gardeniae Fructus at different harvest time. The detection wavelength was 238, 320 and 440 nm. Principal component analysis(PCA), correlation analysis, regression analysis and partial least squares(PLS) analysis were used to explore the relationship of color and content of eight components in Gardeniae Fructus.

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