Heterogeneous responses and resistant mechanisms to crizotinib in ALK-positive advanced non-small cell lung cancer.

Background: ALK-tyrosine kinase inhibitors (TKIs) have been proven effective for treating ALK-positive non-small cell lung cancer (NSCLC), although patients present with variable responses and disease progression courses. The detailed underlying molecular mechanisms require further investigation to yield a better prognosis.

Methods: Targeted next-generation sequencing (NGS) mutation profiling was performed on samples from 42 NSCLC patients confirmed positive for ALK rearrangements by fluorescence in situ hybridization or immunohistochemistry who experienced disease progression after crizotinib treatment.

Interfacial interactions between plastic particles in plastics flotation.

Plastics flotation used for recycling of plastic wastes receives increasing attention for its industrial application. In order to study the mechanism of plastics flotation, the interfacial interactions between plastic particles in flotation system were investigated through calculation of Lifshitz-van der Waals (LW) function, Lewis acid-base (AB) Gibbs function, and the extended Derjaguin-Landau-Verwey-Overbeek potential energy profiles. The results showed that van der Waals force between plastic particles is attraction force in flotation system.

Flotation separation of waste plastics for recycling-A review.

The sharp increase of plastic wastes results in great social and environmental pressures, and recycling, as an effective way currently available to reduce the negative impacts of plastic wastes, represents one of the most dynamic areas in the plastics industry today. Froth flotation is a promising method to solve the key problem of recycling process, namely separation of plastic mixtures. This review surveys recent literature on plastics flotation, focusing on specific features compared to ores flotation, strategies, methods and principles, flotation equipments, and current challenges.

Separation of polycarbonate and acrylonitrile-butadiene-styrene waste plastics by froth flotation combined with ammonia pretreatment.

The objective of this research is flotation separation of polycarbonate (PC) and acrylonitrile-butadiene-styrene (ABS) waste plastics combined with ammonia pretreatment. The PC and ABS plastics show similar hydrophobicity, and ammonia treatment changes selectively floatability of PC plastic while ABS is insensitive to ammonia treatment. The contact angle measurement indicates the dropping of flotation recovery of PC is ascribed to a decline of contact angle.

Flotability and flotation separation of polymer materials modulated by wetting agents.

The surface free energy, surface tension and contact angles were performed to investigate the properties of wetting agents. Adsorption of wetting agents changes wetting behavior of polymer resins. Flotability of polymer materials modulated by wetting agents was studied, and wetting agents change significantly flotability of polymer materials.

Floatability of polymer materials modulated by frothers.

Flotation tests of 35 polymer materials were carried out to investigate their floatability modulated by frothers. Results of flotation tests demonstrated that polymer resins and soft PVC showed high floatability, floatability of hard PVC plastics was relatively low and was related to the frothers, and there exists significant difference in the floatability of different post-consumer plastics. Flotation rate of post-consumer plastics varies from 0% to 100%.