Sacubitril Valsartan Enhances Cardiac Function and Alleviates Myocardial Infarction in Rats through a SUV39H1/SPP1 Axis.

Sacubitril valsartan (lcz696) has been demonstrated as a substitute for angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for the treatment of heart failure. This research is aimed at examining the effects of lcz696 and its target molecules on myocardial infarction (MI). A rat model of MI was induced by left anterior descending artery ligation and treated with lcz696.

Circular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction.

Introduction: Myocardial infarction is coronary artery-related heart disease, and the leading cause of mortality globally. Circular RNAs (circRNAs) are a new type of regulatory RNAs and participate in multiple pathological cardiac progression.

Methods: However, the function of circFoxo3 in MI-induced myocardial injury remains obscure.

AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing Nlrp3 Inflammasome Activation.

Background: Hypoadiponectinemia is a high risk factor for type 2 diabetes and cardiovascular disease. Although adiponectin is a protective molecule in cardiovascular diseases, it is hampered due to short plasma half-life and high cost of production. This study aimed to investigate whether AdipoRon, a small-molecule adiponectin receptor agonist, alleviated saturated free fatty acids such as palmitic acid (PA)-induced cardiomyocyte injury by suppressing Nlrp3 inflammasome activation.

[Driving force analysis of land use change in the developed area based on Probit regression model: A case study of Nanjing City, China].

Based on the remote sensing image in 1996, 2002 and 2010, with the help of RS and GIS technology, and using the Probit regression model, this paper analyzed the characteristics of land use change in Nanjing City from 1996 to 2010, and the driving factors of land use change. The results showed that the cultivated land and woodland decreased, constructive land, garden plot and grassland continued to increase, and the comprehensive land use change rate was rising since 1996. The results of regression model for cultivated land and woodland change indicated that the change of cultivated land in the years 1996-2002 was mainly affected by the factors of "distance to the nearest rural settlement" and "farmers' population density".

Inhibitory effect of midkine-binding peptide on tumor proliferation and migration.

Background: To investigate the inhibitory effect of midkine-binding peptides on human umbilical vein endothelial cells (HUVECs) proliferation and angiogenesis of xenograft tumor.

Methods: The midkine-binding peptides were panned by Ph.D.